Second Cancers Following Radiation Treatment for Cervical Cancer. An International Collaboration Among Cancer Registries

Boice, John D.; Day, Nicholas E.; Andersen, Aage; Brinton, Louise A.; Brown, Robert S.; Choi, N. W.; Clarke, E. Aileen; Coleman, Michel P; Curtis, Rochelle E.; Flannery, James; Hakama, M; Hakulinen, Timo; Howe, G. R.; Jensen, Ole Møller; Kleinerman, Ruth A.; Magnin, Dominique; Magnus, Knut; Mäkelä, Keijo; Malker, Birgitta; Miller, Anthony B.; Nelson, Nancy A.; Patterson, Curtis; Pettersson, Ronja; Pompekirn, B.; Primic-Žakelj, Maja; Prior, Philip; Ravnihar, B; Skeet, R. G.; Skjerven, J.E.; Smith, Pamela J. Olúbùnmi; Sok, Mihael; Spengler, Robert F.; Storm, Hans; Stovall, Marilyn; Tomkins, Garrick; Wall, Christine

doi:10.1016/s0022-5347(17)47726-3

Cited by 89 publications

(123 citation statements)

References 0 publications

Supporting

Mentioning

111

Contrasting

Unclassified

Order By: Relevance

“…However, cervical cancer survivors may face an increased risk of a subsequent tobacco-related cancer diagnosis due to prior treatment [37], and their high prevalence of persistent smoking after a cancer diagnosis [9,10]. According to our findings, cervical cancer survivors have a higher risk of a subsequent tobacco-related cancer diagnosis (including stomach, esophageal, lung and pancreatic cancer), when compared to the risk among other cancer survivors.…”

Section: Discussionmentioning

confidence: 47%

Cervical cancer survivors at increased risk of subsequent tobacco-related malignancies, United States 1992–2008

Underwood

Rim

Fairley

et al. 2012

Cancer Causes Control

View full text Add to dashboard Cite

Purpose-Persistent smoking among cancer survivors may increase their risk of subsequent malignancies, including tobacco-related malignancies. Despite these risks, nearly 40 % of women diagnosed with cervical cancer continue to smoke after diagnosis. This study describes the relative risk of developing any subsequent and tobacco-related malignancy among cervical cancer survivors.Methods-We examined data from the year 1992 to 2008 in 13 Surveillance, Epidemiology and End Results registries. We calculated the standardized incidence ratio (SIR) and 95 % confidence limits (CLs) for all subsequent and tobacco-related malignancies among cervical cancer survivors. Tobacco-related malignancies were defined according to the 2004 Surgeon General's Report on the Health Consequences of Smoking. For comparison with cervical cancer survivors, SIRs for subsequent malignancies were also calculated for female survivors of breast or colorectal cancers.Results-The SIR of developing a subsequent tobacco-related malignancy was higher among cervical cancer survivors (SIR = 2.2, 95 % CL = 2.0-2.4). Female breast (SIR = 1.1, 95 % CL = 1.0-1.1) and colorectal cancer survivors (1.1, 1.1-1.2) also had an elevated risk. The increased risk of a subsequent tobacco-related malignancy among cervical cancer survivors was greatest in the first 5 years after the initial diagnosis and decreased as time since diagnosis elapsed.Conclusion-Women with cervical cancer have a two-fold increased risk of subsequent tobacco-related malignancies, compared with breast and colorectal cancer survivors. In an effort to decrease their risk of subsequent tobacco-related malignancies, cancer survivors should be targeted for tobacco prevention and cessation services. Special attention should be given to cervical cancer survivors whose risk is almost twice that of breast or colorectal cancer survivors.

show abstract

Section: Discussionmentioning

confidence: 47%

Cervical cancer survivors at increased risk of subsequent tobacco-related malignancies, United States 1992–2008

Underwood

Rim

Fairley

et al. 2012

Cancer Causes Control

View full text Add to dashboard Cite

show abstract

“…Boice et al (1985) examined data from 15 cancer registries in eight countries and compared the number of second cancers reported for 182 040 women against the number expected had the same risk prevailed as in the general population. They found an increased risk for cancers of the bladder, rectum, vagina, and caecum.…”

Section: Discussionmentioning

confidence: 99%

Treatment of squamous cell carcinoma of the uterine cervix with radiation therapy alone: long-term survival, late complications, and incidence of second cancers

et al. 2007

View full text Add to dashboard Cite

The objective of this retrospective study was to determine the survival rate, incidence of late complications, and incidence of second cancers when radiation therapy alone is used for carcinoma of the uterine cervix. Between 1971 and 1995, 1495 patients with squamous cell carcinoma of the uterine cervix (stages I -IV) were treated with radiation therapy alone in our hospital. Radiation therapy consisted of a combination of high-dose-rate intracavitary brachytherapy and external beam radiotherapy. The cumulative 5-year survival rates for stages Ib, II, and III/IVa carcinoma were 93.5, 77.0, and 60.3%, respectively, and the 10-year survival rates were 90.9, 74.5, and 56.1%, respectively. Local control rates for stages Ib, II, and III/IVa carcinoma were 92.0, 79.4 and 64.2%, respectively. Eighty-two (5.5%) patients suffered grade III/IV or V (fatal) complications. A second cancer developed in 13 (0.87%) patients. Second cancers were observed most frequently in the rectum (five cases), colon (three cases), and uterine body (two cases). Long-term follow-up data revealed that our method of radiation therapy alone for locally advanced carcinoma of the uterine cervix is effective, with low incidences of late complications and second cancers.

show abstract

“…In a large international study of the incidence of second cancers in women treated with radiation for cervical cancer, the relative risk for cancers of sites close to and at intermediate distances from the cervix also increased significantly with time since treatment, and the increasing trend lasted for at least 30 years following exposure (Boice et al, 1985).…”

Section: Neoplastic Diseasementioning

confidence: 99%

Long term mortality after a single treatment course with X-rays in patients treated for ankylosing spondylitis

Darby¹,

Doll²,

Gill³

et al. 1987

Br J Cancer

300

View full text Add to dashboard Cite

Summary Mortality up to 1 January 1983 has been studied in 14,106 patients with ankylosing spondylitis given a single course of X-ray treatment during For leukaemia there was a threefold increase in mortality that is also likely to have been due to the radiotherapy. The relative risk was at its highest between 2.5 and 4.9 years after the treatment and then declined, but the increase did not disappear completely, and the risk was still nearly twice that of the general population more than 25.0 years after treatment. There was some evidence that the risks of acute myeloid, acute lymphatic, and chronic myeloid leukaemia were all increased, but no evidence of any increase in chronic lymphatic leukaemia. The relative risk appeared to be greatest for acute myeloid leukaemia.For colon cancer, which is associated with spondylitis through a common association with ulcerative colitis, mortality was increased by 30%.For non-neoplastic conditions there was a 51% increase in mortality that was likely to be associated with the disease itself rather than its treatment. (Court Brown & Doll, 1965) and related the incidence of leukaemia to the dose received. These analyses included many patients who had been treated with X-rays for their spondylitis more than once and it was not clear whether the increase that continued for many years should be attributed to the first or subsequent courses. When Smith & Doll (1978;1982) reported on the follow-up of the patients to 1970, they avoided this difficulty by restricting the analyses to patients who had received only a single course of treatment. Their analyses showed that, when the mortality of the spondylitic patients was compared with that of the general population, the relative risk of leukaemia was at a maximum 3-5 years after treatment and subsequently declined. For other cancers of sites judged to be heavily irradiated, the relative risk was at a maximum 9-11 years after treatment and then declined to less than one after 24 years. Only a small proportion of patients had been followed beyond 20 years, however, and the decreasing trend in relative risk for these other cancers more than 11 years after treatment was not statistically significant. We have, therefore, sought to find out how long the increased mortality from leukaemia and other cancers persisted following X-ray treatment by extending the follow-up of patients who received only a single course of treatment by a further 13 years and have related the increased mortality to organ dose. We report here only the data for total and organ specific mortality and have deferred discussion of the complex relationship with dose to a later report. Material and methodsStudy population andfollow-up

show abstract

Second Cancers Following Radiation Treatment for Cervical Cancer. An International Collaboration Among Cancer Registries

Cited by 89 publications

References 0 publications

Cervical cancer survivors at increased risk of subsequent tobacco-related malignancies, United States 1992–2008

Cervical cancer survivors at increased risk of subsequent tobacco-related malignancies, United States 1992–2008

Treatment of squamous cell carcinoma of the uterine cervix with radiation therapy alone: long-term survival, late complications, and incidence of second cancers

Long term mortality after a single treatment course with X-rays in patients treated for ankylosing spondylitis

Contact Info

Product

Resources

About