Second case of uterine mesonephric adenocarcinoma

Abstract

A second report of an intramural mesonephric adenocarcinoma of the uterus is presented. The histogenesis and clinicopathologic outcome of a surgically staged malignancy add to the insights and experience of this uncommon disorder.

Mesonephric carcinoma of the uterine corpus: A report of two cases

“…Since the tumours of the 2 patients of the present case report were located in the uterine myometrium, the patients were accordingly subjected to the same type of surgery that is usually performed to treat endometrial cancer. This procedure differs from omentectomy, which has been previously reported to be conducted on a patient with corpus mesonephric carcinoma (2). Omentectomy remains a controversial procedure for the treatment of corpus mesonephric carcinoma; however, there has been one case report of a patient undergoing this procedure (2).…”

“…This procedure differs from omentectomy, which has been previously reported to be conducted on a patient with corpus mesonephric carcinoma (2). Omentectomy remains a controversial procedure for the treatment of corpus mesonephric carcinoma; however, there has been one case report of a patient undergoing this procedure (2). Although it is considered that the omentum and the mesonephric remnant are homologous in terms of embryology (2), if the tumor does not invade the serous layer or if there is no omental involvement, then there is no mesonephric remnant located in the omentum (1,4).…”

“…Compared with mesonephric carcinoma of the uterine corpus, cervical mesonephric carcinoma is more frequently observed, with 27 of the 29 cases of mesonephric carcinoma reported in the English literature occurring in the cervix, and 2 in the corpus (2). In 2013, Meguro et al (3) summarized 42 cases of cervical mesonephric adenocarcinoma, including 10 cases with sarcomatous components and 4 cases with exogenous or polypoid tumours.…”

“…Due to the lack of androgens, the mesonephric duct degenerates in female embryos. The mesonephric remnant in females is typically located in the ovary, broad ligament and cervical sidewalls, although it may rarely be located in the vaginal wall or myometrium (2). Due to the limited number of cases reported of mesonephric carcinoma occurring within the myometrium, there is limited information regarding the diagnosis and treatment of this malignancy.…”

“…The mesonephric duct, which parallels the paramesonephric duct during the embryonic stage, forms the male epididymis, vas deferens, seminal vesicles, partial prostate and urethra (2). Due to the lack of androgens, the mesonephric duct degenerates in female embryos.…”