2022
DOI: 10.26434/chemrxiv-2022-fthql
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Second-Derivative-Based Background Drift Removal for Tonic Dopamine Measurement in Fast-Scan Cyclic Voltammetry

Abstract: The dysregulation of dopamine, a neuromodulator, is associated with a broad spectrum of brain disorders, including Parkinson’s disease, addiction, and schizophrenia. Quantitative measurements of dopamine are essential for understanding dopamine functional dynamics. Fast-scan cyclic voltammetry (FSCV) is the most widely used electrochemical technique for measuring real-time in vivo dopamine level changes. Standard FSCV has only been used to analyze “phasic dopamine” (changes in seconds), because the gradual gen… Show more

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