Second Malignancies Among Elderly Survivors of Cancer

Vanderwalde, Ari M.; Hurria, Arti

doi:10.1634/theoncologist.2011-0214

Cited by 36 publications

(21 citation statements)

References 64 publications

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“…As the survival of cancer patients improves, second primary malignancy has been increasingly diagnosed among cancer survivors . Many cancer survivors are at increased risk of developing second primary lung cancer (lung‐2), due to shared hazardous lifestyles, cancer treatment, and intrinsic genetic factors of the first primary ones . However, it is largely unknown whether lung‐2 itself has a different aggressiveness compared to lung cancer as the first primary malignancy (lung‐1).…”

Section: Introductionmentioning

confidence: 99%

Mortality of lung cancer as a second primary malignancy: A population‐based cohort study

et al. 2019

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Lung cancer as a second primary malignancy (lung‐2) is increasingly common, but its prognosis is poorly understood. This study aims to examine the overall and cancer‐specific survival of patients diagnosed with lung‐2 compared to lung‐1. Primary lung cancer patients diagnosed from 1988 to 2014 in the Surveillance, Epidemiology, and End Results (SEER) program were included. Lung‐2 was identified in patients with a previous diagnosis of nonlung primary malignancy in SEER. Hazard ratios (HRs) of overall and lung cancer‐specific mortality were estimated among patients with lung‐2 compared to lung‐1, adjusting for age and calendar period at diagnosis, sex, race, socioeconomic status, tumor stage, histology, tumor grade, and treatment. A total of 679 541 and 85 758 patients were identified as lung‐1 and lung‐2, respectively. Compared to lung‐1, patients with lung‐2 were more likely to be diagnosed at localized stage, with smaller primary tumor, and treated with surgery. Lung‐2 patients were at lower risk of lung cancer‐specific mortality in the first 5 years (HR, 0.77; 95% CI, 0.76‐0.78 at <1 year; HR, 0.87; 95% CI, 0.86‐0.89 from 1 to <5 years) but at higher risk thereafter (HR, 1.32; 95% CI, 1.27‐1.37 from 5 to 10 years), independent of tumor characteristics and cancer treatment. Similar pattern was found for overall mortality, although the survival benefit was restricted to the first year after diagnosis. Patients diagnosed with lung‐2 face a favorable lung cancer‐specific survival within the early period after diagnosis. A conservative approach to manage lung‐2 solely based on malignancy history is not supported.

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Section: Introductionmentioning

confidence: 99%

Mortality of lung cancer as a second primary malignancy: A population‐based cohort study

et al. 2019

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“…Em geral, a prevalência das malignidades primárias múltiplas é entre 0,7% a 11,7%, elevando-se proporcionalmente com a idade do paciente (3,7,(8)(9) . Calcula-se que 75% dos portadores tenham mais de 50 anos (3) .…”

Section: Discussionunclassified

Adenocarcinoma sincrônico de esôfago e reto: relato de caso / Synchronous adenocarcinoma of esophagus and rectum: case report

Martins¹,

Gusmão²,

Grynszpan³

et al. 2018

Arq Med Hosp Fac Cienc Med Santa Casa São Paulo

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Relatamos caso raro de paciente com 69 anos que desenvolveu dois tumores sincrônicos do trato gastrointestinal, localizados em topografia de esôfago e reto, com diagnóstico simultâneo. A paciente foi submetida a sessões de radioterapia combinada com tratamento quimioterápico e aguarda esofagectomia subtotal com esofagogastroplastia programadas, com posterior abordagem cirúrgica da região colorretal.Descritores: Neoplasias primárias múltiplas, Trato gastrointestinal, Neoplasias esofágicas, Neoplasias colorretais, Adenocarcinoma, Esôfago/patologia, Reto/patologia

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“…Multiple primary malignancies are defined as those that are confirmed, independent, and of non-metastatic origin and they are classified as synchronous if they are identified within the first six months after the appearance of the first lesion or as metachronous if they are identified thereafter (2). The overall prevalence of multiple primary malignancies is reported as 0.7-11.7%, increasing proportionally with patient's age (2,3,4). It is estimated that 75% of cases occur in individuals over 50 years of age2.…”

Section: Discussionmentioning

confidence: 99%

Case report of a rare occurrence of multiple metachronous malignant neoplasm in a female patient

Sakthiraj¹,

Getheeswaran²,

Uthayakumaran³

2016

Jaffna Med. J.

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It is a rare case of a 53 year old female patient with three different malignancies occurring metachronously; papillary carcinoma of the thyroid followed by malignant phyllodes tumor of her left breast and finally acute myeloid leukaemia. As the patient in the report had received postoperative local ionising radiation treatment seven years prior to her development of acute myeloid leukaemia, the role of the exposure to ionising radiation as the causative mechanism in the development of this malignancy cannot be completely ruled out. This case report suggests that patients who have had a first cancer successfully treated are at higher risk of developing a second or even a third subsequent cancer; therefore, long term regular followup is essential for successfully treated cancer patients for the early diagnosis of the development of subsequent malignancies and their effective treatment.

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Second Malignancies Among Elderly Survivors of Cancer

Cited by 36 publications

References 64 publications

Mortality of lung cancer as a second primary malignancy: A population‐based cohort study

Mortality of lung cancer as a second primary malignancy: A population‐based cohort study

Adenocarcinoma sincrônico de esôfago e reto: relato de caso / Synchronous adenocarcinoma of esophagus and rectum: case report

Case report of a rare occurrence of multiple metachronous malignant neoplasm in a female patient

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