Second-order derivative spectrophotometric assay for imipramine hydrochloride and diazepam in pure admixtures and in dosage forms

Umapathi, P.; Parimoo, P.

doi:10.1016/0731-7085(95)01316-d

Cited by 15 publications

(5 citation statements)

References 8 publications

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“…It is therefore suitable for routine quality control. The detection limits obtained for TCAs by using the mixed aggregates methodology are 1 or 2 orders of magnitude better than those obtained by conventional photometric methods [19][20][21] and similar to those achieved by fluorimetric methods. 22,23…”

Section: Resultsmentioning

confidence: 49%

Quantitation of Tricyclic Antidepressant Drugs Based on the Formation of Mixed Aggregates with Surfactants

Andrés¹,

Sicilia²,

Rubio³

et al. 1998

Journal of Pharmaceutical Sciences

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A new approach for the quantitation of drugs, based on the measurement of the critical micelle concentration of mixed surfactant-drug aggregates, is proposed. This methodology involves the photometric titration of drugs in an aqueous medium using a surfactant as titrant. The Coomassie Brilliant Blue G (CBBG) dye, negatively charged, is used as a photometric probe. The analytical applicability of this approach is demonstrated by quantifying tricyclic antidepressants (TCAs) such as imipramine, desimipramine, amitriptylin, and nortriptylin. Aggregates studied included TCA-sodium dodecyl sulfate (SDS) and TCA-Triton X-100 mixtures. Because of the opposite charge of TCAs and SDS, which causes strong synergistic effects in the mixture relative to the properties of their individual components, this anionic surfactant was selected for the quantitation of TCAs. Pharmaceutical preparations can be analyzed directly after dissolution of the samples in water or ethanol. The detection limit achieved for the studied drugs is about 0.12 mg L-1, so the proposed method surpasses existing alternative photometric methods in sensitivity and features a detection limit similar to fluorimetric methods. The relative standard deviation for 0.8 mg L-1 of TCA is 2.6%.

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Section: Resultsmentioning

confidence: 49%

Quantitation of Tricyclic Antidepressant Drugs Based on the Formation of Mixed Aggregates with Surfactants

Andrés¹,

Sicilia²,

Rubio³

et al. 1998

Journal of Pharmaceutical Sciences

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show abstract

“…These methods include; spectrophotometry [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18], spectrofluorimetry [19][20][21][22][23][24], titrimetry [25][26][27][28][29][30], chromatography [31][32][33][34][35][36][37][38][39][40][41][42], flow injection analysis [43][44][45][46][47], radio-immunoassay [48][49], electrochemical methods [50][51] and chemiluminescence methods [52]…”

Section: Introductionmentioning

confidence: 99%

A validated spectrofluorimetric method for determination of some psychoactive drugs

Mohamed

Hussein

et al. 2005

Journal of Pharmaceutical and Biomedical Analysis

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“…Also, spectrophotometric methods have been reported. [17][18][19][20][21][22] Some of these methods are based on hydrolyzing the drug with HCl and condensation of the primary amine formed with phenylacetaldehyde or p-dimethylaminocinnamaldehyde and extraction of the colored product into CHCl 3 . A colorimetrically determination of diazepam by measuring the purple color formed during the reaction of glycine, as hydrolysis product of diazepam, and ninhydrine was reported.…”

Section: Introductionmentioning

confidence: 99%

Quantitative Determination of Diazepam in Pharmaceutical Preparation by Using a New Extractive-Spectrophotometric Method

2002

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A simple and sensitive extraction-spectrophotometric method in the visible region is described for the determination of diazepam in bulk sample and pharmaceutical formulations. The method is based on 1 : 1 ion-association complex formation with the acidic dye, bromocresol green at pH 3.5, which is extractable into chloroform from the aqueous phase. Spectrophotometric measurement was done at 410 nm. Different variable affecting the reaction were studied and optimized. Beer's law is obeyed in a general concentration ANALYTICAL LETTERS range of 2-60 mgÁmL À1 for the investigated complex. Sandell sensitivity for 0.001-absorbance unit is 57 ngÁcm À2 . The proposed method could be applied successfully to the determination of diazepam in tablets and injections with good accuracy and precision. The results were compared with the official method. By using the method, diazepam was recovered from a blood serum sample.

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Second-order derivative spectrophotometric assay for imipramine hydrochloride and diazepam in pure admixtures and in dosage forms

Cited by 15 publications

References 8 publications

Quantitation of Tricyclic Antidepressant Drugs Based on the Formation of Mixed Aggregates with Surfactants

Quantitation of Tricyclic Antidepressant Drugs Based on the Formation of Mixed Aggregates with Surfactants

A validated spectrofluorimetric method for determination of some psychoactive drugs

Quantitative Determination of Diazepam in Pharmaceutical Preparation by Using a New Extractive-Spectrophotometric Method

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