The half-linear q-difference equationwhere Φ(x) = |x| 𝛼 sgnx, 𝛼 > 0, p ∶ q N 0 → (0, ∞), r ∶ q N 0 → R, is analyzed in the framework of q-regular variation. Necessary and sufficient conditions for the existence of q-regularly varying solutions are given, under the assumption that p is a q-regularly varying function and with no sign restriction on r. It is examined in the case when r is eventually negative, whether all positive solutions are q-regularly varying. Using generalized regularly varying sequences, these results are applied to the half-linear difference equation case.