Second Primary Cancer Following Laryngeal Cancer with Special Reference to Smoking Habits

Hiyama, Tomohiko; Sato, Takeo; Yoshino, Kunitoshi; Tsukuma, Hideaki; Hanai, Aya; Fujimoto, Isaburo

doi:10.1111/j.1349-7006.1992.tb00111.x

Cited by 51 publications

(36 citation statements)

References 5 publications

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“…Such site combinations can be seen in the first group in Table 5. The combination of [lip, oral cavity and pharynx] versus esophagus has been reported as significantly correlated in several papers (14,(20)(21)(22)(23) and the correlation is thought to be attributable to tobacco smoking and alcohol consumption. We also identified a marginally correlated site combination among tobacco-related cancers, [lip, oral cavity and pharynx] versus larynx.…”

Section: Discussionmentioning

confidence: 99%

“…In several countries, epidemiological studies on MPC based on a large-scale population-based cancer registry have provided some insights into MPC from the etiological point of view. In Japan, several studies have reported the risks of MPCs following first primary cancers (7)(8) of the colon and rectum (9), non-Hodgkin's lymphoma (10), thyroid gland (11), stomach (12)(13), pharynx and larynx (14)(15), uterine cervix (16), head and neck (17) and breast (18). Since the cancer incidence pattern in Japan is known to be very different from that in Western countries, it is hoped that these studies of MPCs in Japan will provide some additional insights into the etiology of cancer.…”

Section: Introductionmentioning

confidence: 99%

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Epidemiological Analysis of Site Relationships of Synchronous and Metachronous Multiple Primary Cancers in the National Cancer Center, Japan, 1962-1996

Kaneko

Yamaguchi

1999

Japanese Journal of Clinical Oncology

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Background: Multiple primary cancer (MPC) has been recognized as a problem commonly encountered in routine medical practice. A study of MPC is necessary not only to provide insights into the etiology of cancer, but also to provide information for effective medical care by clinical oncologists. Methods: A cohort of 49751 cancer patients who were admitted to the National Cancer Center Hospital between 1962 and 1996 was used to study the site relationship of MPC. Logistic and Poisson regression analyses using an internal reference group within the cohort were applied for the calculation of the prevalence odds ratio (POR) for site relationships of synchronous MPC and the incidence rate ratio (IRR) for those of metachronous MPC. Results: Three site combinations with elevated risks for both synchronous and metachronous MPCs, eight with elevated risk for synchronous MPC, five with elevated risk for metachronous MPC and six with decreased risk for synchronous MPC were identified with statistical significance. Among them, the increased risk of metachronous stomach cancer following lymphoma and myeoloma (POR = 1.0 and 1.1, P> 0.05; IRR = 2.5, P < 0.05) and the inverse site-correlation of synchronous MPC between [trachea, bronchus and lung] and other sites of the upper aerodigestive tract [lip, oral cavity and pharynx] (POR = 0.5 and 0.3, P < 0.05) and esophagus (POR =0.7 and 0.3, P < 0.05) have not been reported previously. Conclusions:Our results suggest that interventions for lymphoma and myeloma might affect the development of subsequent stomach cancer and additional etiological factors other than tobacco smoking are associated with the development of cancer in the upper aerodigestive tract.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Epidemiological Analysis of Site Relationships of Synchronous and Metachronous Multiple Primary Cancers in the National Cancer Center, Japan, 1962-1996

Kaneko

Yamaguchi

1999

Japanese Journal of Clinical Oncology

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“…The reported incidence of esophageal carcinoma associated with multiple primary squamous cell carcinomas of the upper aerodigestive tract in series of head and neck tumor patients varies from 0% to 6.3% (1,2,3,4,5,7,8,9,10,11,12,13,14,17,18,19,22,25) ( Table 2). Furthermore, the incidence of multiple primary tumors in series of patients with squamous cell carcinoma of the esophagus ranged from 3.3% to 12.4% (2,4,9,20,21,24) ( Table 3).…”

Section: Discussionmentioning

confidence: 99%

Squamous cell carcinoma of the esophagus and multiple primary tumors of the upper aerodigestive tract

Ribeiro

Ivan

Safatle‐Ribeiro

et al. 1999

Arq. Gastroenterol.

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“…Major risk factors in developed countries include smoking tobacco and drinking alcohol, and chewing betel quid (4,5). For tobacco smoking, a dose-response trend has been reported.…”

Section: Introductionmentioning

confidence: 99%

Genetic polymorphisms and head and neck cancer risk (Review)

Hiyama¹,

Yoshihara²,

Tanaka³

et al. 2008

Int J Oncol

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Abstract. The aim of this report is to review and evaluate, in a comprehensive manner, the published data regarding the contribution of genetic polymorphisms to risk of head and neck cancer (HNC). All relevant studies available in MEDLINE and published before July 2007 were identified. Studies carried out in humans that compared HNC patients with at least 1 standard control group were considered for analysis. Two hundred and eighteen publications and 3 published metaanalyses were identified. Seventy-five (34%) studies were conducted in Asian, 72 (33%) in American, and 68 (31%) in European countries. The most widely studied gene was GSTM1 (58 studies), followed by GSTT1 (42 studies), GSTP1 (codon 105, 22 studies) and p53 (codon 72, 20 studies). GSTM1, GSTT1, GSTP1, XRCC1 codons 194 and 399, and CYP1A1 codon 462 were examined by meta-analyses, and significant relations were found between the GSTM1-null genotype and an increased risk for HNC. In addition, increased risk for HNC was associated consistently with the ALDH2*1/*2, p53 codon 72 Pro/Pro and EPHX1 codon 113 Tyr/His and His/His genotypes. Cohort studies that simultaneously consider multiple genetic and environmental factors possibly involved in carcinogenesis of the head and neck are needed to ascertain not only the relative contribution of these factors to tumor development but also the contributions of their putative interactions. IntroductionHead and neck cancers (HNCs), including cancers of the oral cavity, pharynx and larynx, represent the 6 most frequent cancers and the seventh leading cause of cancer-related death worldwide. There are approximately 540,000 new cases and 271,000 deaths annually worldwide for a mortality of approximately 50% (1). HNCs represent approximately 3% of all cancers in the United States whereas these cancers are much more prevalent in other areas of the world, such as India, Thailand and Brazil (1,2). Standard therapeutic approaches, which focus on surgery, irradiation and chemotherapy (alone or in combination), have been modified over the last 30 years; however, the overall survival of HNC patients has not improved substantially. For patients affected by early-stage cancers with a high disease-specific survival rate, secondary tumors represent the most common cause of death (3). Furthermore, patients with advanced cancers have a high risk of primary treatment failure and death.Development of HNC is a multifactorial process associated with a variety of risk factors. Major risk factors in developed countries include smoking tobacco and drinking alcohol, and chewing betel quid (4,5). For tobacco smoking, a dose-response trend has been reported. Relative risks of developing laryngeal and oropharyngeal cancers are 1.8 and 1.3, respectively, for persons who smoke ≤30 cigarettes per day and 7.7 and 2.9, respectively, for persons who smoke >30 cigarettes per day compared with non-smokers (6). Alcohol consumption is also linked to increased risk of HNCs. For persons who consume >4 drinks (=47.5 g of pure ethanol) per day, the relati...

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Second Primary Cancer Following Laryngeal Cancer with Special Reference to Smoking Habits

Cited by 51 publications

References 5 publications

Epidemiological Analysis of Site Relationships of Synchronous and Metachronous Multiple Primary Cancers in the National Cancer Center, Japan, 1962-1996

Epidemiological Analysis of Site Relationships of Synchronous and Metachronous Multiple Primary Cancers in the National Cancer Center, Japan, 1962-1996

Squamous cell carcinoma of the esophagus and multiple primary tumors of the upper aerodigestive tract

Genetic polymorphisms and head and neck cancer risk (Review)

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