Second primary cancers in laryngeal cancer patients in Slovenia, 1961–1996

Ecimovic, P.; Pompe-Kirn, Vera

doi:10.1016/s0959-8049(02)00012-6

Cited by 14 publications

(11 citation statements)

References 15 publications

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“…The survival rates observed in our study are comparable to those studies conducted in European cancer registries 8, 9, 10. Age at the time of diagnosis was observed to be a strong predictor of survival, for overall as well as for cause specific mortality, particularly in the age group of 70 years and above.…”

Section: Discussionsupporting

confidence: 88%

Lifestyle habits as prognostic factors in survival of laryngeal and hypopharyngeal cancer: A multicentric European study

Dikshit

Boffetta

Bouchardy³

et al. 2005

Intl Journal of Cancer

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Little information is available on the role of tobacco, alcohol and diet in the survival of upper aero digestive cancers. Our study analysed the survival of 931 laryngeal and hypopharyngeal cancer patients, enrolled in a population based case-control study conducted at 5 centres in southeast Europe during 1979Europe during -1982. Age at the time of diagnosis and site of origin of tumour were observed to be predictors of the survival. Cigarette smoking, and to a limited extent alcohol drinking, before the diagnosis of tumour seem to influence the overall survival whereas high intakes of vegetables and vitamin C were observed to favourably affect the prognosis. For mortality from upper aerodigestive cancer protective effects of high intakes of vegetables, fibres and vitamin C were observed. Our results support the hypothesis that there is a role for dietary intervention to improve survival of laryngeal and hypopharyngeal cancer patients. ' 2005 Wiley-Liss, Inc.Key words: laryngeal cancer; hypopharyngeal cancer; survival; smoking; alcohol drinking; diet The incidence and mortality from laryngeal/hypopharyngeal cancer is relatively high in southern Europe. Tobacco smoking, alcohol drinking and dietary factors have been linked to the development of upper aerodigestive cancer. 1 It is reasonable to argue that these factors might also influence the survival. Little is known, however, about a possible role of lifestyle related factors on survival of laryngeal/hypopharyngeal cancer.We address the role of tobacco, alcohol and dietary factors in the survival of laryngeal and hypopharyngeal cancer by using the data from multicentric population-based case-control study conducted in 5 southern European centres in early 80s. To our knowledge this is the first large-scale study to describe the role of smoking, alcohol and dietary factors on laryngeal/hypopharyngeal cancers prognosis. Two studies published previously on this topic are the analyses of same data set by 2 centres individually. 2,3 Such information should be useful for clinical and public health intervention to improve the survival. Material and methodsA multicentric population-based case-control study of laryngeal and hypopharyngeal cancer was carried out in 6 European regions covered by a cancer registry: the canton of Geneva (Switzerland), the department of Calvados (France), the city of Turin and the province of Varese (Italy) and the provinces of Navarra and Zaragoza (Spain). A common protocol was designed and interviews were conducted to define the role of tobacco, alcohol, diet and occupation in the development of these cancers. The details of our study design have been reported previously. 4 The patient group enrolled in our study was followed up for the occurrence of second primary tumour and vital status. The follow-up was conducted by linkage with population, mortality and cancer registry files. The follow-up could not be carried out for the cases from Calvados. For each subject, the starting date of follow-up was defined as the date of diagnosis of lar...

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Section: Discussionsupporting

confidence: 88%

Lifestyle habits as prognostic factors in survival of laryngeal and hypopharyngeal cancer: A multicentric European study

Dikshit

Boffetta

Bouchardy³

et al. 2005

Intl Journal of Cancer

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“…A second primary neoplasm was defined according to IARC (International Agency for Research on Cancer) rules [9,10], as follows: 1. The existence of two or more primary cancers does not depend on time; 2.…”

Section: Methodsmentioning

confidence: 99%

Clinical features and outcome of multiple primary malignancies involving hepatocellular carcinoma: A long-term follow-up study

et al. 2012

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BackgroundThe prolonged survival of individuals diagnosed with cancer has led to an increase in the number of secondary primary malignancies. We undertook to perform a definitive study to characterize and predict prognosis of multiple primary malignancies (MPM) involving hepatocellular carcinoma (HCC), due to the scarcity of such reports.MethodsClinicopathological data were analyzed for 68 MPM patients involving HCC, with 35 (target group) underwent curative liver resection. Additional 140 HCC-alone patients with hepatectomy were selected randomly during the same period as the control group.ResultsOf the 68 patients with extrahepatic primary malignancies (EHPM), 22 were diagnosed synchronously with HCC, and 46 metachronously. The most frequent EHPM was nasophargeal carcinoma, followed by colorectal and lung cancer. Univariate analysis demonstrated that synchronous (P = 0.008) and non-radical treatment for EHPM (P < 0.001) were significant risk factors associated with poorer overall survival (OS). While, Cox modeling revealed that the treatment modality for EHPM, but not the synchronous/metachronous determinant, was an independent factor for OS, and that therapeutic option for HCC was an independent factor for HCC-specific OS. Moreover, no HCC-specific overall and recurrence-free survival benefit were observed in the control group when compared with that of the target group (P = 0.607, P = 0.131, respectively).ConclusionsCurative treatment is an independent predictive factor for OS and HCC-specific OS, and should been taken into account both for synchronous and metachronous patients. MPM patients involving HCC should not be excluded from radical resection for HCC.

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“…In contrast to this moderate percentage, obtained by retrospective analysis, prospective clinical studies in France, Germany, Brazil, and Japan have consistently shown that 6 to 14 percent of patients with head and neck cancer already harbor or eventually have invasive esophageal squamous-cell cancer. 1 Similarly, the risk of esophageal squamous-cell cancer may be as high as 3.3 to 8.2 percent in persons with a history of heavy alcohol and tobacco consumption. 2 The survival benefit achieved by screening for and treating early esophageal neoplasia 3 underlines the efficacy of surveillance in groups at very high risk.…”

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confidence: 99%

“…Photodynamic therapy completely ablates high-grade dysplasia and most superficial adenocarcinomas, without the high morbidity and mortality associated with esophagectomy. 1 Provided that staging can be performed accurately and more advanced disease can be ruled out, photodynamic therapy appears to be promising and merits discussion. the authors reply: Drs.…”

mentioning

confidence: 99%

“…Although the risk of esophageal squamous-cell cancer is increased in this clinical setting, an incidence of less than 1 percent has been reported in other series. 1,2 Dr. Mohammed is correct in stating that nutrition may have a significant effect on the risk of perioperative complications in patients with esophageal cancer. In patients with clinically significant weight loss, nutritional support should be consid-ered.…”

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confidence: 99%

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