Second Primary Lung Cancer with Glottic Laryngeal Cancer as Index Tumor – A Case Report

Akhtar, Jamal; Bhargava, Rakesh; Shameem, Mohammad; Singh, Sudhir; Baneen, Ummul; Khan, Nafees A.; Hassan, Jassem; Sharma, Prakhar

doi:10.1159/000279320

Cited by 6 publications

(10 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…U monoklonskoj maligne stanice migriraju od primarnog tumora i tvore mjesto razvoja potencijalnog tumora. Poliklonska teorija kaže da se mjesta sekundarnih tumora formiraju neovisno i to na jače izraženim poljima kancerizacije [15][16][17][18][19][20][21][22] . Genetska promjena u pločastom epitelu kao niti sam pojam polja kancerizacije do danas nije razjašnjen, a dokaz mutacijske progresije u tumorogenezi planocelularnog karcinoma glave i vrata pokušava se dokazati poremećajem dijelova kromosoma [13][14][15][16][17][18][19][20][21][22] .…”

Section: Raspravaunclassified

“…Poliklonska teorija kaže da se mjesta sekundarnih tumora formiraju neovisno i to na jače izraženim poljima kancerizacije [15][16][17][18][19][20][21][22] . Genetska promjena u pločastom epitelu kao niti sam pojam polja kancerizacije do danas nije razjašnjen, a dokaz mutacijske progresije u tumorogenezi planocelularnog karcinoma glave i vrata pokušava se dokazati poremećajem dijelova kromosoma [13][14][15][16][17][18][19][20][21][22] . Nova genetska istraživanja tek će pokazati značaj kao i mogući uzrok nastanka polja kancerizacije, no dok se ne razviju pouzdani genski testovi te moguće kemoprevencije javljanja drugog primarnog tumora, najbolja opcija u liječenju bit će otkrivanje drugog primarnog tumora u ranom stadiju [22][23][24][25] .…”

Section: Raspravaunclassified

“…Genetska promjena u pločastom epitelu kao niti sam pojam polja kancerizacije do danas nije razjašnjen, a dokaz mutacijske progresije u tumorogenezi planocelularnog karcinoma glave i vrata pokušava se dokazati poremećajem dijelova kromosoma [13][14][15][16][17][18][19][20][21][22] . Nova genetska istraživanja tek će pokazati značaj kao i mogući uzrok nastanka polja kancerizacije, no dok se ne razviju pouzdani genski testovi te moguće kemoprevencije javljanja drugog primarnog tumora, najbolja opcija u liječenju bit će otkrivanje drugog primarnog tumora u ranom stadiju [22][23][24][25] . U otkrivanju drugog primar-nog tumora kod pacijenata s uspješno liječenim inicijalnim tumorom glave i vrata vrlo su važne redovite kontrole pri čemu se u 9 -14 % slučajeva nađe sinkroni, a u 10 -20 % slučajeva metakroni tumor [22][23][24][25] .…”

Section: Raspravaunclassified

“…Nova genetska istraživanja tek će pokazati značaj kao i mogući uzrok nastanka polja kancerizacije, no dok se ne razviju pouzdani genski testovi te moguće kemoprevencije javljanja drugog primarnog tumora, najbolja opcija u liječenju bit će otkrivanje drugog primarnog tumora u ranom stadiju [22][23][24][25] . U otkrivanju drugog primar-nog tumora kod pacijenata s uspješno liječenim inicijalnim tumorom glave i vrata vrlo su važne redovite kontrole pri čemu se u 9 -14 % slučajeva nađe sinkroni, a u 10 -20 % slučajeva metakroni tumor [22][23][24][25] . Ovisno o sijelu pronalaska, sekundarni tumor se u 42 -70 % slučajeva opet nalazi u predjelu glave i vrata, 5 -26 % ih se nalazi na plućima, a 5 -43 % u jednjaku.…”

Section: Raspravaunclassified

“…Ovisno o sijelu pronalaska, sekundarni tumor se u 42 -70 % slučajeva opet nalazi u predjelu glave i vrata, 5 -26 % ih se nalazi na plućima, a 5 -43 % u jednjaku. Ovisno o vremenu pronalaska drugog metakronog tumora ono iznosi prosječno 31 -43 mjeseca nakon otkrića primarnog tumora [22][23][24][25][26][27] . Činjenica o pojavi sinkronih, a poglavito metakronih tumora larinksa, potvrđuje da je sluznica larinksa jedno jedinstveno polje kancerizacije, što čini podlogu za nastanak novog tumora [1][2][3][4][5][6][7][8][9][10][11][12][13] .…”

Section: Raspravaunclassified

See 4 more Smart Citations

Metakroni karcinom larinksa – prikaz slučaja

Grabovac

Grabovac²,

Puharić³

et al. 2019

Med. Flum. (Online)

View full text Add to dashboard Cite

Sažetak. Cilj: Ukazati na potrebu trajnog praćenja pacijenata kod kojih je zbog karcinoma učinjena parcijalna laringektomija. Prikaz slučaja: Prikazali smo pacijenta koji je u vremenskom razmaku od dvadeset godina tri puta imao karcinom larinksa. 1982. godine učinjena je parcijalna laringektomija. Drugi primarni tumor nastao je na sluznici ostatka larinksa 2000. godine, kada je učinjena traheotomija i laringofisura s ekscizijom tumora. Treće javljanje tumora bilo je 2002. godine kada je učinjena retraheotomija i totalna laringektomija. U sva tri javljanja radilo se o planocelularnom karcinomu. Pacijent je od 2000. godine bio pod redovitom kontrolom, a preminuo je 2013. godine u dobi od 85 godina. Zaključak: Pojava planocelularnog karcinoma larinksa moguća je godinama nakon uspješnog liječenja početnog tumora. Objašnjenje nalazimo u ostatku sluznice koja je obilježena poljima kancerizacije, što čini podlogu za nastanak novih tumora. Ključne riječi: metakroni karcinom larinksaAbstract. Aim: To point out the need for permanent monitoring of patients with partial laryngectomy due to cancer. Case report: We have shown a patient who has had the laryngeal cancer three times at intervals of twenty years In 1982, a partial laryngectomy was performed. The second primary tumour was formed on the mucosa of the rest of the larynx in 2000, when the tracheotomy and laryngofissure were performed. The third tumour incidence was in 2002, when retracheotomy and total laryngectomy were performed. In all three cases, there was the case of a planocellular carcinoma. The patient was regularly checked-up since 2000, but he passed away in 2013 at the age of 85. Conclusion: The appearance of the laryngeal planocellular carcinoma is possible years after the successful treatment of the primary tumour. The explanation is found in the remains of the mucosa, which is marked by the field of cancerisation, which is the basis for the incidence of new tumours.

show abstract

Section: Raspravaunclassified

See 3 more Smart Citations

Metakroni karcinom larinksa – prikaz slučaja

Grabovac

Grabovac²,

Puharić³

et al. 2019

Med. Flum. (Online)

View full text Add to dashboard Cite

show abstract

Hierarchical multivariate directed acyclic graph autoregressive models for spatial diseases mapping

Gao

Datta

Banerjee

2022

Statistics in Medicine

View full text Add to dashboard Cite

Disease mapping is an important statistical tool used by epidemiologists to assess geographic variation in disease rates and identify lurking environmental risk factors from spatial patterns. Such maps rely upon spatial models for regionally aggregated data, where neighboring regions tend to exhibit similar outcomes than those farther apart. We contribute to the literature on multivariate disease mapping, which deals with measurements on multiple (two or more) diseases in each region. We aim to disentangle associations among the multiple diseases from spatial autocorrelation in each disease. We develop multivariate directed acyclic graphical autoregression models to accommodate spatial and inter-disease dependence. The hierarchical construction imparts flexibility and richness, interpretability of spatial autocorrelation and inter-disease relationships, and computational ease, but depends upon the order in which the cancers are modeled. To obviate this, we demonstrate how Bayesian model selection and averaging across orders are easily achieved using bridge sampling. We compare our method with a competitor using simulation studies and present an application to multiple cancer mapping using data from the Surveillance, Epidemiology, and End Results program.

show abstract

Spatial Difference Boundary Detection for Multiple Outcomes Using Bayesian Disease Mapping

Banerjee

Ritz²

2022

Biostatistics

View full text Add to dashboard Cite

Summary Regional aggregates of health outcomes over delineated administrative units (e.g., states, counties, and zip codes), or areal units, are widely used by epidemiologists to map mortality or incidence rates and capture geographic variation. To capture health disparities over regions, we seek “difference boundaries” that separate neighboring regions with significantly different spatial effects. Matters are more challenging with multiple outcomes over each unit, where we capture dependence among diseases as well as across the areal units. Here, we address multivariate difference boundary detection for correlated diseases. We formulate the problem in terms of Bayesian pairwise multiple comparisons and seek the posterior probabilities of neighboring spatial effects being different. To achieve this, we endow the spatial random effects with a discrete probability law using a class of multivariate areally referenced Dirichlet process models that accommodate spatial and interdisease dependence. We evaluate our method through simulation studies and detect difference boundaries for multiple cancers using data from the Surveillance, Epidemiology, and End Results Program of the National Cancer Institute.

show abstract

Second Primary Lung Cancer with Glottic Laryngeal Cancer as Index Tumor – A Case Report

Cited by 6 publications

References 15 publications

Metakroni karcinom larinksa – prikaz slučaja

Metakroni karcinom larinksa – prikaz slučaja

Hierarchical multivariate directed acyclic graph autoregressive models for spatial diseases mapping

Spatial Difference Boundary Detection for Multiple Outcomes Using Bayesian Disease Mapping

Contact Info

Product

Resources

About