Second primary lung carcinoma.

Abstract

Ffity-five patients suffering from second primary lung carcinoma, 10 synchronous and 45 after resection for lung carcinoma (metachronous), have been observed from 1400 resections. The first manifestation of a second carcinoma in this series has always been the appearance of a new shadow in the follow-up radiograph. In our experience, second primary lung carcinoma is a disease affecting only heavy cigarette smokers. Heavy cigarette smokers suffering from squamous-cell carcinoma are at special risk. The results of re-operation, the significance of the time interval between the original operation and the appearance of the second primary carcinoma, and the slow growth rate of some second primaries are briefly discussed. No clear-cut methods exist for distinguishing a second primary from a metastasis from the original carcinoma.

Metachronous second primary malignant fibrous histiocytoma in two skeletal muscles

“…An [20], skin [5], breast [3], stomach [21], kidney [22], ureters [23], bladder [4], head and neck epithelial cancers [24], and melanoma [25]. Examples of Again, the spindled cells have a GI mean DNA value within 2 SD of control cell value (near-diploid DNA content).…”

Second primary lung carcinoma

“…Smith et a1 in England, reported their experience in 1976 [ 5 ] . Between 1953 and1973, second primary lung cancers were diagnosed in 55 patients from a total of 1,400 who underwent resection of their original tumor, an incidence of 3.9%.…”

“…The Memorial series included, as mentioned before, one patient with a 16-year interval between three primaries [4]. Smith refers to a patient of Jackson's who had a 16-year interval between both primaries [5] . In Shields's series [8] , the second lung primary was diagnosed after a ten-year interval in eight patients; the precise figure is not reported, even though, his follow-up does not go beyond 14 years.…”

New Directions in Lung Cancer: Chemoprevention

“…As predicted by the concept of field cancerization and multistep carcinogenesis process, there is a high risk of developing second primary tumors among patients with lung cancer and head and neck cancer who have been successfully treated for their first pri mary tumor. [34][35][36][37][38][39][40][41][42][43][44] The hypothesis is that the carcino gen-exposed field, with wide areas of preneoplastic lesions, is more vulnerable to further development of frank malignancies. The majority of second pri mary tumors found in most series have been nonsmall-cell lung cancers, squamous cell carcinomas of the head and neck, or esophageal cancers, all tobaccoassociated tumors.…”