Second primary malignancies among cancer patients

Zheng, Xuan-Qi; Li, Xiao; Wang, Minqi; Shen, Jianfei; Sisti, Giovanni; He, Zelai; Huang, Jinfeng; Li, Yan Michael; Wu, Ai-Min

doi:10.21037/atm-20-2059

Cited by 27 publications

(19 citation statements)

References 29 publications

(27 reference statements)

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“…Donin and colleagues reported that the most common SPM was lung cancer (18%), followed by colorectal cancer (12%), prostate cancer (9%), and bladder cancer (8%) in cancer survivors aged ≥ 18 years 13 . Two other studies also found lung cancer as the most common SPM in adults 19 , 20 . Among the survivors of AYA cancer, the most common SPM was breast cancer (32%), followed by melanoma (14%) and ovarian cancer (5%) 14 .…”

Section: Discussionmentioning

confidence: 75%

Second primary malignancy among malignant solid tumor survivors aged 85 years and older

Zhang

Liu

Qu³

et al. 2021

Sci Rep

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The cancer burden in the oldest old has increased rapidly. This study aimed to investigate the epidemiology of second primary malignancy (SPM) in malignant solid tumor survivors aged 85 years and older utilizing the Surveillance, Epidemiology, and End Results (SEER) database. A total of 128,466 malignant solid tumor patients had been identified between 2000 and 2011, including 6774 patients who developed a SPM. The overall crude incidence of developing a SPM was 5.3%. Considering death as a competing event, the 3, 5, and 10-year cumulative incidence was 1.9%, 3.2%, and 5.4%, respectively. Relative younger age, male gender, surgery history, local stage and first primary malignancy (FPM) site located in the urinary system were related to higher cumulative incidence. A median time interval of 24.0 months was found between diagnosis of FPM and SPM. The most common SPM site was digestive system, whereas the least common was oral cavity and pharynx. The median overall survival (OS) was 49.0 months, and the median survival after SPM was 13.0 months. Relative older age, male gender and black race were associated with worse OS and survival after SPM, as well as higher hazard ratios of death. In conclusions, this study performed a comprehensive analysis of SPM among malignant solid tumor survivors aged 85 years and older. Additional studies are needed to characterize the specific cancer type of interest.

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Section: Discussionmentioning

confidence: 75%

Second primary malignancy among malignant solid tumor survivors aged 85 years and older

Zhang

Liu

Qu³

et al. 2021

Sci Rep

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“…The continuous progress in medicine and improvement in living standards have extended the lifespan of humans. In addition, the detection rate of multiple primary cancers has gradually increased[ 4 ].…”

Section: Discussionmentioning

confidence: 99%

Synchronous gastric cancer complicated with chronic myeloid leukemia (multiple primary cancers): A case report

Zhao¹,

Yang²,

Ma³

et al. 2022

World J Clin Cases

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BACKGROUND With the advancement of medical technology and improvement in living standards, the incidence of multiple primary cancers has gradually increased. In particular, tumors of the digestive system account for a large proportion of multiple primary cancers. The diagnosis and treatment of chronic myeloid leukemia, particularly with synchronous gastric cancer, at the first consultation is relatively rare. CASE SUMMARY Herein, we present the case of a middle-aged man who was referred to the Department of Hematology owing to an elevated white blood cell count. After the examination, he was diagnosed with chronic myeloid leukemia and was administered imatinib. Three months after the initial diagnosis, he visited our hospital again for abdominal pain, and further examination revealed gastric malignancy. After discussion with a multidisciplinary team, S-1 (Tegafur, Gimeracil, and Oteracil Potassium Capsules) combined with oxaliplatin—SOX regimen—was initiated. Later, the patient’s condition rapidly progressed. He developed colonic obstruction and underwent an ostomy; however, he died less than 6 months after the initial diagnosis. CONCLUSION Multiple primary cancers are influenced by environmental and genetic factors; a standardized multidisciplinary discussion plays a key role in treatment.

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“…The second primary cancer was found in many patients with posttreatment primary malignancies during their follow-up, and the proportion of which is higher than that in the general population (9)(10)(11)(12)(13). Results of a retrospective study indicated that the overall risk of developing a second primary cancer is statistically significantly higher for 18 of 30 primary malignancies in men and 21 of 31 primary malignancies in women when compared with the general population ( 14).…”

Section: Discussionmentioning

confidence: 99%

Second Primary Lung Adenocarcinoma After Intensity-Modulated Radiotherapy for Nasopharyngeal Carcinoma

Xue

Niu

et al. 2022

Front. Oncol.

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ObjectiveThe improvement of the efficacy of intensity-modulated radiotherapy (IMRT) for nasopharyngeal cancer (NPC) has prolonged the survival of patients, and the incidence of the second tumor has gradually increased. Among them, second primary lung adenocarcinoma (SPLAC) attributes the highest incidence. This study aimed to determine the long-term risk of SPLAC in NPC patients after IMRT.MethodsFrom May 2005 to May 2018, a total of 1,102 non-metastatic NPC patients who received IMRT in our hospital were enrolled, and the incidence and efficacy of SPLAC were followed up in the long term.ResultsOver a median follow-up period of 66 months, a total of 22 cases of SPLAC were observed, with an incidence of 2.0%. The 1-, 2-, 3-, 4-, and 5-year cumulative risks of SPLAC were 0.4%, 0.7%, 0.8%, 1.1%, and 1.7%, respectively. During follow-up, 90.9% (20/22) of the SPLAC detected was in early stage, and the recurrence rate of surgery alone was 5.3% (1/19).ConclusionIn NPC patients, the proportion of SPLAC after IMRT was similar to that of the normal population, and most of them were found in early stage during follow-up, with good surgical efficacy.

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Second primary malignancies among cancer patients

Cited by 27 publications

References 29 publications

Second primary malignancy among malignant solid tumor survivors aged 85 years and older

Second primary malignancy among malignant solid tumor survivors aged 85 years and older

Synchronous gastric cancer complicated with chronic myeloid leukemia (multiple primary cancers): A case report

Second Primary Lung Adenocarcinoma After Intensity-Modulated Radiotherapy for Nasopharyngeal Carcinoma

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