Second primary malignancy of the aerodigestive tract in patients treated for cancer of the oral cavity and larynx

Lin, Karen; Patel, Snehal G.; Chu, Pen–Yuan; Matsuo, Jeannette Marie S.; Singh, Bhuvanesh; Wong, Richard J.; Kraus, Dennis H.; Shaha, Ashok R.; Shah, Jatin P.; Boyle, Jay O.

doi:10.1002/hed.20272

Cited by 108 publications

(103 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In the case of duplicate information, we used the publication providing the most adjusted risk estimation, up to date and complete data about second primary cancer sites, and defined alcohol consumption. Twenty potentially relevant full-text publications were identified (10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29). We excluded one duplicate publication, as confirmed by the authors (10).…”

Section: Study Selectionmentioning

confidence: 99%

Alcohol Drinking and Second Primary Cancer Risk in Patients with Upper Aerodigestive Tract Cancers: A Systematic Review and Meta-analysis of Observational Studies

Druesne-Pecollo

Keita

Touvier

et al. 2014

Cancer Epidemiology, Biomarkers &Amp; Prevention

View full text Add to dashboard Cite

Background: We conducted a systematic review and meta-analysis of existing data from observational studies to assess the strength of the association of alcohol drinking with second primary cancer risk in patients with upper aerodigestive tract (UADT; oral cavity, pharynx, larynx, and esophagus) cancer.Methods: PubMed and Embase were searched up to July 2012 and the reference lists of studies included in the analysis were examined. Random-effects models were used to estimate summary relative risks (RR) and 95% confidence interval (CI).Results: Nineteen studies, 8 cohort and 11 case-control studies, were included. In highest versus lowest meta-analyses, alcohol drinking was associated with significantly increased risk of UADT second primary cancers (RR, 2.97; 95% CI, 1.96-4.50). Significantly increased risks were also observed for UADT and lung combined (RR, 1.90; 95% CI, 1.16-3.11) and all sites (RR, 1.60; 95% CI, 1.22-2.10) second primary cancers. For an increase in the alcohol intake of 10 grams per day, dose-response meta-analysis resulted in a significantly increased RR of 1.09 (95% CI, 1.04-1.14) for UADT second primary cancers.Conclusions: Alcohol drinking in patients with UADT cancer is associated with an increased risk of second primary cancers. Studies conducted in alcohol drinking patients with UADT cancer and evaluating the effect of alcohol cessation on second primary cancer and other outcomes are needed.Impact: Our results emphasize the importance of prevention policies aiming to reduce alcohol drinking. Health-care professionals should encourage alcohol drinking patients with UADT cancer to reduce their consumption and reinforce the surveillance of this at-risk subpopulation. Cancer Epidemiol Biomarkers Prev; 23(2); 324-31. Ó2013 AACR.

show abstract

Section: Study Selectionmentioning

confidence: 99%

Alcohol Drinking and Second Primary Cancer Risk in Patients with Upper Aerodigestive Tract Cancers: A Systematic Review and Meta-analysis of Observational Studies

Druesne-Pecollo

Keita

Touvier

et al. 2014

Cancer Epidemiology, Biomarkers &Amp; Prevention

View full text Add to dashboard Cite

show abstract

“…Further evidence from recent investigations into UAD-SPT confirms that patients afflicted with HNSCC-SPT fare better than those with SPT of other origins (pulmonary or oesophageal) [3][4][5][6]. Most recently we analysed the effects of radiotherapy in larynngeal SCCs.…”

Section: Discussionmentioning

confidence: 96%

“…Studies differ widely (2-30%) in their estimated risk of SPT development in part due to inconsistencies in patient selection or diagnostic criteria as well as generally inadequate follow up ( [3][4][5][6]8,10,[13][14][15][16][17][18][19][20][21][22][23][24][25][26]. It is generally accepted that diagnosis of the index tumour in concert with the premise of field cancerisation imparts a subsequent permanent risk of developing SPT [2][3][4][5][6]20,27].…”

Section: Discussionmentioning

confidence: 99%

“…In a recent series of 1257 patients (595 Oral SCCs and 662 Larynngeal SCCs) Lin et al [5] reported a significantly better disease-specific survival, disease-free survival and a better 3-year survival trend for patients with UAD-SPTs. Further evidence from recent investigations into UAD-SPT confirms that patients afflicted with HNSCC-SPT fare better than those with SPT of other origins (pulmonary or oesophageal) [3][4][5][6].…”

Section: Discussionmentioning

confidence: 99%

“…Second primary tumours (SPT), a well established phenomenon in HNSCC, are universally considered to be a poor prognostic indicator for OS. Reports of SPT incidence vary from 2-30% [2][3][4][5][6]. These involve the upper aerodigestive (UAD) tract as well as remote sites.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Second Primary Tumours of the Head and Neck are not Associated ith Adverse Overall Survival in Oral Sccs

Farhadieh¹,

Otáhal²,

Taghavi³

et al. 2011

JCST

View full text Add to dashboard Cite

Objective: Second primary tumours (SPT) have been implicated in the dismal overall survival (OS) of head and neck Squamous cell carcinomas (HNSCC). The incidence of SPT, the SPT diagnostic time-lag and the impact on OS were assessed.Subjects and methods: 363 consecutive patients treated for primary oral SCCs (1967SCCs ( -2004 were analyzed retrospectively in this study. 95.1% and 90.5% of patients reached a minimum follow-up period of 3 and 5 years respectively.Results: Of 363 patients; 68 (18.7%) were diagnosed with metachronous SPT, 49 (13.5%) developed upper aerodigestive tract (UAD)-SPT, 28 (7.7%) were diagnosed with HNSCC-SPT, and 21 (5.8%) developed lung or esophageal carcinoma. Patients with subsequent HNSCC-SPT had a better median survival during follow-up than those not diagnosed with SPTs (p=0.0018). The rate of mortality in these patients showed a substantial increase compared to patients with no subsequent SPT Diagnosis after 144 months. After 200 months the survival experience was no better than those without SPT. Conclusion:These results suggest a better OS for patients afflicted with HNSCC-SPT. This also reflects that at least some of the noted improved OS of HNSCC-SPT patients is due to temporally cumulated risk associated with developing SPT.

show abstract

Incidence and Risk of Second Primary Malignant Neoplasm After a First Head and Neck Squamous Cell Carcinoma

Boakye

Buchanan

Hinyard

et al. 2018

JAMA Otolaryngol Head Neck Surg

View full text Add to dashboard Cite

show abstract

Second primary malignancy of the aerodigestive tract in patients treated for cancer of the oral cavity and larynx

Abstract: The rates of SPMADT after treatment of SCCOC and SCCL are comparable, but the patterns are different. Smoking and alcohol use are independent predictors of SPMADT development.

Cited by 108 publications

References 18 publications

Alcohol Drinking and Second Primary Cancer Risk in Patients with Upper Aerodigestive Tract Cancers: A Systematic Review and Meta-analysis of Observational Studies

Alcohol Drinking and Second Primary Cancer Risk in Patients with Upper Aerodigestive Tract Cancers: A Systematic Review and Meta-analysis of Observational Studies

Second Primary Tumours of the Head and Neck are not Associated ith Adverse Overall Survival in Oral Sccs

Incidence and Risk of Second Primary Malignant Neoplasm After a First Head and Neck Squamous Cell Carcinoma

Contact Info

Product

Resources

About