Secondary Hyperparathyroidism Among Bariatric Patients: Unraveling the Prevalence of an Overlooked Foe

Mendonça, Fernando; Neves, João Sérgio; Silva, Maria M; Borges‐Canha, Marta; Costa, Cláudia; Cabral, Pedro M.; Guerreiro, Vanessa; Lourenço, Rita; Meira, Patrícia; Ferreira, Maria João; Salazar, Daniela; Pedro, Jorge; Viana, Sara; Souto, Selma B.; Varela, Ana; Belo, Sandra; Lau, Eva; Freitas, Paula; Carvalho, Davide

doi:10.1007/s11695-021-05495-7

Cited by 8 publications

(2 citation statements)

References 22 publications

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“…In this study, the prevalence of VDD varied depending on the adequacy of supplementation. Some studies with adequate supplementation showed relatively high VDD prevalence 41 , 57 , while others with inadequate supplementation had low prevalence 12 , 16 , 39 . This suggests that additional factors contribute to VDD.…”

Section: Discussionmentioning

confidence: 99%

Prevalence and associated factors of vitamin D deficiency after Roux-en-Y gastric bypass: A systematic review and meta-analysis

Gao,

Liang,

Huang

et al. 2023

International Journal of Surgery

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Objects: To estimate the prevalence and associated factors of vitamin D deficiency (VDD) after Roux-en-Y gastric bypass (RYGB). Methods: PubMed, EMBASE, and CENTRAL were searched for relevant records from inception to March 17, 2023, using search terms: vitamin D, vitamin D3, vitamin D deficiency, hypovitaminosis D, gastric bypass, and RYGB. Studies were eligible for inclusion if they provided related data on VDD prevalence after RYGB. Results: Of 1119 screened studies, 72 studies involving 7688 individuals were enrolled in the final analysis. The prevalence estimates of VDD after RYGB were 42%. Subgroup analyses suggested the pooled prevalence of postoperative VDD was 35% for follow-up duration ≤1 year, 43% for >1 and ≤5 years, and 54% for >5 years. Meta-regression showed that VDD prevalence was positively correlated with follow-up time. Also, the prevalence was higher in studies with inadequate vitamin D supplementation than in those with adequate supplementation and in Asia population than in those from South America, Europe, and North America. Other factors associated with high VDD prevalence after RYGB included high presurgical VDD prevalence, non-compliant patients, and black populations. No significant association existed between VDD and alimentary length. Conclusion: VDD presented a high prevalence in patients following RYGB. It occurred more frequently with longer postoperative follow-up time. Population-specific vitamin D supplementation measures, targeted treatment for presurgical VDD, improved patient compliance, and periodical follow-ups were necessary to reduce VDD and other adverse outcomes.

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Section: Discussionmentioning

confidence: 99%

Prevalence and associated factors of vitamin D deficiency after Roux-en-Y gastric bypass: A systematic review and meta-analysis

Gao,

Liang,

Huang

et al. 2023

International Journal of Surgery

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“…Primary hyperparathyroidism (PHPT) refers to parathyroid gland hyperfunction caused by hyperplasia, neoplasia, or malignancy. Secondary hyperparathyroidism (SHPT) is a type of hypermetabolism caused by other diseases, like chronic renal failure ( 2 ), post-hemodialysis ( 3 ), kidney transplantation ( 4 ), and bariatric surgery ( 5 ) and leads to increased blood calcium from increased PTH reacting to low blood calcium levels. In tertiary hyperparathyroidism (THPT), long-term overstimulation of the parathyroids leads to the development of nodules due to the compensatory hyperfunction to spontaneous PTH incretion.…”

Section: Introductionmentioning

confidence: 99%

Advances in the treatment of secondary and tertiary hyperparathyroidism

et al. 2022

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Secondary hyperparathyroidism (SHPT) and tertiary hyperparathyroidism (THPT) are common and complicated clinical endocrine diseases. The parathyroid glands maintain endocrine homeostasis by secreting parathyroid hormone to regulate blood calcium levels. However, structural alterations to multiple organs and systems occur throughout the body due to hyperactivity disorder in SHPT and THPT. This not only decreases the patients’ quality of life, but also affects mortality. Since current treatments for these diseases remains unclear, we aimed to develop a comprehensive review of advances in the treatment of SHPT and THPT according to the latest relevant researches.

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Secondary Hyperparathyroidism Before and After Bariatric Surgery: a Prospective Study with 2-Year Follow-Up

Salman

Elewa

et al. 2022

OBES SURG

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Secondary Hyperparathyroidism Among Bariatric Patients: Unraveling the Prevalence of an Overlooked Foe

Cited by 8 publications

References 22 publications

Prevalence and associated factors of vitamin D deficiency after Roux-en-Y gastric bypass: A systematic review and meta-analysis

Prevalence and associated factors of vitamin D deficiency after Roux-en-Y gastric bypass: A systematic review and meta-analysis

Advances in the treatment of secondary and tertiary hyperparathyroidism

Secondary Hyperparathyroidism Before and After Bariatric Surgery: a Prospective Study with 2-Year Follow-Up

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