Secondary hyperparathyroidism in patients with chronic kidney disease: A case control study

Abstract

Secondary hyperparathyroidism is a major complication of Chronic kidney disease resulting from disturbances in the regulation of Parathyroid hormone, calcium, phosphorus and vitamin D. Adding to the burden of CKD elevated Parathyroid hormone levels are responsible for the long-term consequences like renal osteodystrophy, vascular calcifications and also contributes to cardiovascular morbidity and mortality among end-stage renal disease patients. Hence, this study was conducted to correlate the levels of PTH in patients with CKD in comparison to normal healthy controls.: 54 patients diagnosed as CKD and 46 healthy controls are included in the study. Serum levels of Urea, creatinine & PTH measured in both cases and controls. Statistically significant increase in PTH levels were observed in cases as compared to controls (p<0.001). An increase in PTH levels is seen as the disease progressed. Thus, periodic measurement of PTH is recommended in all patients with CKD in order to reduce complications.