Secondary ion mass spectrometry of nucleic acid components: Pyrimidines, purines, nucleosides and nucleotides

Eicke, A.; Sichtermann, W.; Benninghoven, A.

doi:10.1002/oms.1210150605

Cited by 66 publications

(13 citation statements)

References 13 publications

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“…In compounds 2-11 (Table I) another type of ion was observed, formed by dealkylation of the dication. An example is shown in Figure 2 which gives the LMS of l,8-bis(trimethylammonium)octane diiodide (5). The most intense peak (m/z 215) is due to loss of CH3+ from the dication.…”

Section: Resultsmentioning

confidence: 99%

“…Quantitative or semiquantitative analysis of individual particles is still limited, because of the present scarce knowledge about the laser induced ion formation mechanism and the influence of the particle size, the laser power density, the matrix effects, and the instrumental parameter settings. However research about these topics is currently in progress (3)(4)(5).…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Laser mass spectrometry of diquaternary ammonium salts

Dang¹,

Day²,

Hercules³

1984

Anal. Chem.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Laser mass spectrometry of diquaternary ammonium salts

Dang¹,

Day²,

Hercules³

1984

Anal. Chem.

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“…In 1976 Benninghoven and co-workers (2) showed that kiloelectronvolt primary ions at low current densities could be used to desorb intact molecular ions from organic compounds adsorbed on a metal surface with good sensitivity. This technique called "static" SIMS has been used to detect and identify a wide variety of nonvolatile organic samples including amino acids, peptides, vitamins, pharmaceutical compounds, nucleosides, nucleotides, and others (3,4). Closely related to SIMS is fast atom bombardment (FAB), which uses a neutral primary atom beam and a liquid sample matrix (5,6).…”

mentioning

confidence: 99%

Direct comparison of secondary ion and laser desorption mass spectrometry on bioorganic molecules in a moving belt liquid chromatography/mass spectrometry system

Tp¹,

Ed²,

Ml³

1984

Anal. Chem.

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“…In this mode, many successive spectra can be recorded with great reproductibility from the same sample site. These so-called laser desorption (LD) spectra show striking similarities with spectra obtained by field desorption (FD) (Krueger and Schueler, 1980) and to a lesser extent secondary ion mass spectrometry (SIMS) (Eicke et at., 1980), the most important other methods that have been successfully applied in the mass spectrometry of nonvolatile thermally labile bioorganic compounds. The characteristics of these spectra are as follows:…”

Section: Laser Desorption Mass Spectrometrymentioning

confidence: 76%

Laser Applications in Medicine and Biology

Wolbarsht¹

1989

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A Continuation Order Plan is available for this series. A continuation order will bring delivery of each new volume immediately upon publication. Volumes are billed only upon actual shipment.v PREFACE The diversity of the chapters presented in this volume illustrates not only the many applications of lasers, but also the fact that, in many cases, these are not new uses of lasers, but rather improvements of laser techniques already widely accepted in both research and clinical situations. Biological reactions to some special aspects of laser exposure continue to show new effects, which have implications for the ever-present topic of laser safety. Such biological reactions are included in fields of research which depend on properties of electromagnetic radiation exposure only possible with lasers, for example, the short pulses necessary for the temperature-jump experiments reviewed by Reiss:Speciality lasers, such as the transverse excitation atmospheric (TEA) or excimer lasers, add new wavelengths and pulse domains to those already available for biological application. A description of these new types of lasers by Osgood is included to indicate new possibilities for future use and to avoid limiting our coverage to well-developed present-day applications.Hillenkamp and Kaufmann describe a microprobe mass spectrograph for analysis of the minute amounts of material evaporated by a laser pulse. The analytical possibilities of this instrument are far-reaching, and some of the various results are described to illustrate the power of their method, as well as to show the types of problems that are suitable for it.The initial steps in photosynthesis have become the subject of intensive investigation. High-speed laser techniques have assisted in unlocking some of the puzzles of the energy transduction involved, and the present review by Rubin shows both the current state of the art and the possibilities for future experiments.Much of the clinical work using lasers remains in ophthalmology, the first specialty to accept any type of laser exposure as a standard therapy. In addition to its use in the treatment of an ever-increasing number of retinal vii viii Preface problems, laser coagulation has become the standard treatment for glaucoma, for the lens capsule cutting necessitated by the complications of lens implant surgery, and bids fair to proceed even further as lasers are applied to vitreous surgery. The analyses of bioeffects of laser exposures in the eye by Ham and Mueller, and by Allen and Pohlhamus, give some of the scientific background for those applications that have already proven successful and indicate the bases for future clinical applications of lasers in oph thalmology.Each clinical acceptance of a laser instrument broadens the experience of all in the general medical field with regard to laser use. Also, the increasingly larger number of clinicians involved in research on laser surgery adds even more to the diversity of laboratory projects that will in turn become the basis for techniques that in the future...

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Secondary ion mass spectrometry of nucleic acid components: Pyrimidines, purines, nucleosides and nucleotides

Cited by 66 publications

References 13 publications

Laser mass spectrometry of diquaternary ammonium salts

Laser mass spectrometry of diquaternary ammonium salts

Direct comparison of secondary ion and laser desorption mass spectrometry on bioorganic molecules in a moving belt liquid chromatography/mass spectrometry system

Laser Applications in Medicine and Biology

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