Secondary Metabolites and Biological Profiles of Datura Genus

Abstract

Solanaceae is an important family of plants where many species of this family are source for food, industrial products, ornamental and medicinal uses. Within the family of Solanaceae, the genus Datura is one of the most interesting, in principle for its known medicinal and psychotropic uses against different pathologies. Multiple biological activities of Datura species have been documented. The species of the genus are attributed with insecticide, fungicide, antioxidant, antimicrobial, hypoglycemic, and immune response enhancing activity against cancer cells. These activities are related to the presence of different secondary metabolites such us: terpenoids, flavonoids, withanolides, tannins, phenolic compounds and tropane alkaloids, the main secondary metabolite of the genus Datura, being the most abundant atropine and scopolamine. The propose of this review is to identify the main phytochemical compounds isolated from the genus Datura and describe their biological activities associated to different secondary metabolites.

Datura stramonium Flowers as a Potential Natural Resource of Bioactive Molecules: Identification of Anti-Inflammatory Agents and Molecular Docking Analysis

“…The antimicrobial activity of the methanolic leaf extract of D. stramonium was already observed against Bacillus subtilis and Escherichia coli , being more effective than that of root and stem extracts [ 26 ]. Another investigation demonstrated that the methanolic leaf extract of D. stramonium exhibited antibacterial activity against Gram-positive bacteria ( Staphylococcus haemolyticus , Staphylococcus aureus , Shigella dysenteriae , and Bacillus cereus ) and against Gram-negative bacteria, such as Pseudomonas aeruginosa , Klebsiella pneumoniae , and Escherichia coli at 2.5, 1.25, and 0.75 mg/mL, respectively [ 27 ]. It was suggested that the promising antibacterial activity of plant extracts against pathogenic bacterial strains may be mainly related to their chemical composition as polyphenols, flavonoids, alkaloids, saponins, glycosides, and steroids [ 28 , 29 ].…”

Heterocyclic compounds as a magic bullet for diabetes mellitus: a review

“…Aloe, 59 mint, 60 banaba, 61 bitter melon, 62 caper bush, 63 cinnamon, 64 cocoa, 65 coffee, 66 fenugreek, 67 garlic, 68 guava, 69 turmeric, 70 tea, 71 walnuts, 72 Shaggy bindweed, 73 Yerba mates , 74 Bambusa tulda , 75 Ficus bengalensis , 76 Ferula orientalis, 77 Gymnema sylvestre , 78 Dioscorea japonica , 79 Artemisia abyssinica , 80 Phaseolus vulgaris , 81 Datura quercifolia , 82 Cassia fistula , 83 Citrus aurantium , 84 Ficus benghalensis , 85 Polygonum aviculare , 86 Allium tuncelianum , 87 Astragalus brachycalyx , 88 Ferulago stelleta , 89 and Rhizophora mucronate 90 are natural sources that contain chemical moieties which are effective against diabetes. 91 However, recent research-based studies showed more aim to develop new drugs that can be provided orally for the therapeutics uses of diabetes disease.…”

Gene family evolution and natural selection signatures in Datura spp. (Solanaceae)

“…Within the Solanaceae family, the species of the genus Datura produce high concentrations of tropane alkaloids (Jirschitzka et al, 2012;Kohnen-Johannsen and Kayser, 2019;Céspedes-Méndez et al, 2021), metabolites long used as medicines (Roddick, 1991;Geeta and Gharaibeh, 2007;Benítez et al, 2018;Sahu et al, 2022). Ecological evidence indicates that some of these chemical compounds, as well as some terpenoids, play central roles as defenses against herbivores and possibly against pathogens, viruses, and fungi in Datura (Shonle and Bergelson, 2000;Hare and Elle, 2001;Hare and Smith, 2005;Castillo et al, 2014;Kariñho-Betancourt et al, 2015;Miranda-Pérez et al, 2016;De-la-Cruz et al, 2020a, 2021Goldberg et al, 2020;Céspedes-Méndez et al, 2021;Velázquez-Márquez et al, 2021). Furthermore, there is evidence that these species produce different concentrations of total tropane alkaloids (Doncheva et al, 2006;Kariñho-Betancourt et al, 2015).…”