Secondary metabolites from Colletotrichum capsici, an endophytic fungus derived from Siegesbeckia pubescens Makino

Abstract

A rare new tremulane sesquiterpenoid analogue, 11,12-epoxy-5,6-seco-1,6(13)-tremuladien-5,12-olide (1), together with five known altenuene derivatives (2-6) was isolated from the cultures of Colletotrichum capsici, which was isolated as an endophytic fungus from fresh leaves of Siegesbeckia pubescens Makino (Compositae). Their structures were elucidated by means of spectroscopic methods and comparison with literature data. All compounds isolated were reported for the first time from the fungus C. capsici.

Anticandidal Potential of Endophytic Bacteria Isolated from Dryopteris Uniformis (Makino)

“…Several researchers have isolated various endophytes from different parts of plants. Bacterial endophytes have been documented as storehouse of new secondary metabolites for possible remedial use (46)(47)(48)(49). According to Strobel and Daisy (50), the study of endophytes of medicinal and widespread fern plants is required as they are anticipated to harbor unique and exciting endophytes with new bioactive metabolites.…”

“…This has directed to the detection of quite a lot of bioactive composites from bacterial as well as fungal endophytes isolated from medicinal and fern plants (48,(51)(52)(53)(54). Several species in the Bacillus genus are economi-cally significant for use in the construction of numerous molecules and additional products for foodstuffs, pharmaceutical, agricultural, and biological industries (55,56).…”

Sesquiterpenoids From the Antarctic Fungus Pseudogymnoascus sp. HSX2#-11

“…Tremulane derivatives have been found from cultures of Phellinus tremulae (Ayer and Cruz, 1993), P. igniarius (Liu et al, 2007;Wu et al, 2020), Conocybe siliginea (Zhou et al, 2008;Wu et al, 2010;He et al, 2020), Huperzia serrata (Ying et al, 2013), Flavodon flavus (Isaka et al, 2016), Coriolopsis sp. (Chen et al, 2017), Colletotrichum capsici (Wang et al, 2017), I. lacteus (Chen et al, 2018(Chen et al, , 2020Ding et al, 2018Ding et al, , 2019Ding et al, , 2020aZhou et al, 2018;Duan et al, 2019;Wu et al, 2019;Shi et al, 2020;Wang et al, 2020), and Gymnopilus junonius (Lee et al, 2020). This is the first time to find tremulane derivatives from Pseudogymnoascus.…”

“…Tremulanes, a family of sesquiterpenoids with characteristic structures of 5/7 fused bicyclic system, were rarely discovered in nature until 2015 (Guo et al, 2016). However, from 2016 to 2020, about 60 tremulane derivatives were found (Guo et al, 2016;Isaka et al, 2016;Wu, 2016;Chen et al, 2017Chen et al, , 2018Cong et al, 2020;Wang et al, 2017Wang et al, , 2020Ding et al, 2018Ding et al, , 2019Ding et al, , 2020aZhou et al, 2018;Duan et al, 2019;Wu et al, 2019Wu et al, , 2020He et al, 2020;Lee et al, 2020;Shi et al, 2020;, and the number is twice as many as before. Most of them were isolated from the cultures of the basidiomycetes Irpex lacteus (Chen et al, 2018(Chen et al, , 2020Ding et al, 2018Ding et al, , 2019Ding et al, , 2020aZhou et al, 2018;Duan et al, 2019;Wu et al, 2019;Shi et al, 2020;Wang et al, 2020).…”

Seco-tremulane Sesquiterpenoids from the Cultures of the Medicinal Fungus Irpex lacteus HFG1102

“…The 5,6- seco -tremulane skeleton, which was regarded as the resultant of Baeyer–Villiger oxidation of tremulane, was first and mainly reported from the basidiomycete Conocybe siliginea [ 3 , 4 ]. To the best of our knowledge, the distribution of this type of sesquiterpenes only reported from three species, the basidiomycete Flavodon flavus BCC 17421 [ 5 ], and the endophytic fungi Colletotrichum capsici [ 6 ] and Ceriporia lacerate [ 7 ]. Notably, this type of sesquiterpenes always presented in inseparable mixtures.…”