Secondary Metabolites from the Genus <i>Xylaria</i> and Their Bioactivities

Song, Fei; Wu, Shao‐Hua; Zhai, Ying-Zhe; Xuan, Qi-Cun; Wang, Tang

doi:10.1002/cbdv.201200286

Cited by 66 publications

(32 citation statements)

References 61 publications

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“…We were particularly intrigued by two extensive m/z subnetworks containing nine and 14 connected nodes with protonated molecular ions (m/z 623.3776 (1), m/z 609.3627 (2), m/z 657.3617 (3), m/z 643.3466 (4), m/z 403.2220 (5), m/z 417.2383 (6)). Dereplication of exact masses by using Antibase [8] and SciFinder indicated that the corresponding m/z signals might represent as yet unreported metabolites.…”

Section: Resultsmentioning

confidence: 99%

“…Although it is as yet unclear how Pseudoxylaria senses a favorable environment, we hypothesize that Pseudoxylaria-derived secondary metabolites assist in the repression of the fungal mutualist. [4] Based on antagonistic behavior and the fact that Xylariaceae in general have been the source of a wide range of bioactive compounds, [5] we set out to gain deeper insights into the metabolic capacities of this subgenus. Based on its phylogenetic distinct position, we decided to focus on the strain named Pseudoxylaria sp.…”

Section: Introductionmentioning

confidence: 99%

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Targeted Discovery of Tetrapeptides and Cyclic Polyketide‐Peptide Hybrids from a Fungal Antagonist of Farming Termites

Schalk

Guo

et al. 2020

ChemBioChem

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Dedicated to Prof. Rolf Huisgen. Herein, we report the targeted isolation and characterization of four linear nonribosomally synthesized tetrapeptides (pseudoxylaramide AD) and two cyclic nonribosomal peptide synthetase-polyketide synthase-derived natural products (xylacremolide A and B) from the termite-associated stowaway fungus Pseudoxylaria sp. X187. The fungal strain was prioritized for further metabolic analysis based on its taxonomical position and morphological and bioassay data. Metabolic data were dereplicated based on high-resolution tandem mass spectrometry data and global molecular networking analysis. The structure of all six new natural products was elucidated based on a combination of 1D and 2D NMR analysis, Marfey's analysis and X-ray crystallography.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Targeted Discovery of Tetrapeptides and Cyclic Polyketide‐Peptide Hybrids from a Fungal Antagonist of Farming Termites

Schalk

Guo

et al. 2020

ChemBioChem

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“…Xylaria species play an important ecological role because of their long co-evolution with vascular plants [ 2 30 ]. Moreover, Xylaria species are able to produce ca.…”

Section: Discussionmentioning

confidence: 99%

New Records of Xylaria Species in Korea: X. ripicola sp. nov. and X. tentaculata

Kim

Kwag

et al. 2016

Mycobiology

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During a Korean mushroom diversity survey from 2011 to 2014, we found one new Xylaria species (X. ripicola sp. nov.) and one Xylaria species that had not been previously observed in Korea (X. tentaculata). To confirm the phylogenetic placement of the new species, we conducted a phylogenetic investigation based on internal transcribed spacer regions of ribosomal DNA sequences. Additionally, the new species, X. ripicola, was subsequently analyzed for RNA polymerase II subunit sequences. We also evaluated the macroscopic and microscopic features of this species. Herein, X. ripicola is described as a new species that was collected from a natural beach habitat and X. tentaculata is formally reported as newly found in Korea.

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“…The genus Xylaria, a big family of mycomycetes, has great value in application according to a large amount of literature reports. There were many kinds of compounds such as terpenoids, sterols, alkaloids, polyketones, polysaccharides, cyclic peptides and carboxylic acids [4][5][6] were isolated from the Xylaria genus, which exhibited antioxidant, antimicrobial, antitumor, enzyme inhibitory abilities. X. striata Pat.…”

Section: Introductionmentioning

confidence: 99%

Anti-aging Activity of Xylaria striata in Drosophila melanogaster

Yuan

Jian

et al. 2019

SAJRM

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Aims: To evaluate the application potential of Xylaria striata Pat. in anti-aging field. Methodology: Extracting the fruit body of X. striata by ultrasonic-assisted extraction method. In this study, Drosophila melanogaster was used as an anti-aging organism material. After feeding with different concentrations of extract, the natural survival time, survival time under oxidative stress and survival time under UV irradiation of D. melanogaster were all measured. In addition, the in vivo activity of SOD、CAT and MAD, protein concentration and body weight were determined to evaluate the anti-aging effect of ethanol extract from X. striata. Results: The results showed that the ethanol extract of X. striata could extend the lifespan of D. melanogaster under both irradiation and oxidative stress condition. And the ethanol extract could enhance the activity of CAT in D. melanogaster, especially at concentration of 50 μM, and the content of MAD in D. melanogaster were decreased significantly. Conclusion: This study clarified the anti-aging activity of X. striata in D. melanogaster and it would provide some theoretical basis for its further development and utilization in anti-aging drugs and health food.

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Secondary Metabolites from the Genus Xylaria and Their Bioactivities

Cited by 66 publications

References 61 publications

Targeted Discovery of Tetrapeptides and Cyclic Polyketide‐Peptide Hybrids from a Fungal Antagonist of Farming Termites

Targeted Discovery of Tetrapeptides and Cyclic Polyketide‐Peptide Hybrids from a Fungal Antagonist of Farming Termites

New Records of Xylaria Species in Korea: X. ripicola sp. nov. and X. tentaculata

Anti-aging Activity of Xylaria striata in Drosophila melanogaster

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