Secondary Metabolites from the Leaves of Aquilaria sinensis

S.S.Chien,; Wu, Huiming; Li, Wei‐Jen; Chen, Ching-Tong; Li, Hsing-Tan; Chen, Hsin‐Liang; Chao, David; Chen, Sheue-Jiun; Huang, Cheng-Tsumg; Chen, Chung‐Yi

doi:10.1007/s10600-014-1174-7

Cited by 7 publications

(13 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…An example is the use of leaves that were reported to be used locally in trauma-related diseases such as fracture, bruise etc. It was also reported that agarwood has significant anticancer activities, analgesic and anti-inflammatory activities and anti-depressant activities [ 55 ]. Research on the phytochemicals from this genus ( Aquilaria ) will continue certainly because there are still some species that have not been studied.…”

Section: Discussionmentioning

confidence: 99%

Review: Secondary Metabolites of Aquilaria, a Thymelaeaceae Genus

Kristanti

Tanjung

Aminah

2018

MROC

View full text Add to dashboard Cite

Background:Aquilaria, a genus belonging to the Thymelaeaceae, produces fragrant resinous agarwood, also known as eaglewood, which has been used as incense since old times. The intense fra-grance is the result of the presence of a wide variety of secondary metabolites.Objective:This genus was reported contained sesquiterpenes, chromones, flavonoids, benzophenones, diterpenoids, triterpenoids, and lignans.Conclusion:Here, we review the different secondary metabolites that have been identified in Aquilaria to show their diversity and to allow comparison with other Thymelaeaceae genera.

show abstract

Section: Discussionmentioning

confidence: 99%

Review: Secondary Metabolites of Aquilaria, a Thymelaeaceae Genus

Kristanti

Tanjung

Aminah

2018

MROC

View full text Add to dashboard Cite

show abstract

“…Beberapa anggota kelompok senyawa fenol pada daun Aquilaria diantaranya Vanilic acid, Isovanilic acid, Methylparaben dan Syringic acid. Senyawa -senyawa tersebut merupakan metabolit sekunder yang ditemukan pada Aquilaria sinensis (Kang et al, 2014 (Khalil et al, 2013) Kelompok senywa terbesar yang dapat ditemukan pada daun gaharu genus Aquilaria adalah Flavonoid. Senyawa genkwanin merupakan golongan flavonoid yang paling banyak dilaporkan terdapat pada daun Aquilaria berdasarkan hasil penelitian dan menjadi salah satu senywa ciri khas dari daun gaharu (Wang., 2008, Ito et al, 2012, Yu et al, 2013Qi et al, 2009.…”

Section: Fitokimia Daun Gaharuunclassified

“…Senyawa genkwanin merupakan golongan flavonoid yang paling banyak dilaporkan terdapat pada daun Aquilaria berdasarkan hasil penelitian dan menjadi salah satu senywa ciri khas dari daun gaharu (Wang., 2008, Ito et al, 2012, Yu et al, 2013Qi et al, 2009. Selain itu terdapat pula senywa flavonoid Apigenin (Ariffin et al, 2013), Luteolin (Yu et al, 2013 turunan senyawa Luteolin dan dimethoxyflavone (Kang et al, 2014), Epicatechin gallate dan Epigallocatechin gallate (Tay et al, 2014) dan Vitexin (Sun et al, 2105).…”

Section: Fitokimia Daun Gaharuunclassified

“…Ekstrak daun A. agallocha dilaporkan bersifat antibakteri terhadap Shigella flexeneri, Bacillus brevis, Pseudomonas aeruginosa dan Bacillus subtilis (Dash et al, 2008). Ekstrak etanol daun A. microcarpa memiliki aktivitas antibakteri terhadap Staphylococcus aureus dan Proteus mirabilis (Sari et al, 2017) .Selain menghambat pertumbuhan bakteri, daun Aquilaria agallocha mengandung senyawa cucrbitacins yang memiliki potensi antifungal (Chen et al, 2014).…”

Section: Khasiat Medis Daun Aquilariaunclassified

See 1 more Smart Citation

Medicinal Effect Review of Agarwood Leaves From Aquilaria and Gyrinops Genera

Wangiyana

2020

JSS

View full text Add to dashboard Cite

Aquilaria and Gyrinops are the most common genera of Agarwood in Indonesia. These two group have wide distribution in Indonesia. Therefore, Indonesia is one of the biggest agarwood commodity producer in the world. However, the resin on agarwood stem is still main utilization of agarwood commodity in this country. Diversification agarwood utilization other than resin is needed to maximilize the potency of this commodity. Agarwood leaves are one of by product from agarwood cultivation that rarely been utilized. Agarwood leaves contain secondary metabolites that have medical effect such as Phenol, Flavonoid, Terpenoid , Alkaloid and Tannin. Thus, agarwood leaves has a good potency as a source of food and beverage product that have a medicinal effects. Agarwood leaves form Aquilaria group and Gyrinops group both have medicinal effect including antioxidant, antibacterial, cytotoxic and anticancer. Aquilaria leaves also has additional medicinal effect including: anti-inflammatory, anti-diabetic and laxative while Gyrinops leaves also has additional medicinal effect as antiradical source of sunscreen.

show abstract

“…Additionally, the leafy part of the agarwood tree was reported to exhibit potential antioxidant [22,23] and laxative activities [24,25] . Among potentially active compounds reported in the agarwood trees in relation to biomedicinal effect includes phenolic acid (4-hydroxybenzoic acid, palmitic acid, and 9-octadecanoic acid), terpenoids (cucurnitacins, aquilanol A, aquilanol B, and β-agarofuran), phenols (hydroquinone, 4-hyhdroxyacetanilide, and phenol, 2,6-dimethoxy), flavonoids (aquilarinoside A1, 5-hydroxy-4', 7-dimethoxyflavone, and 3'-hydroxy genkwanin, aquilarinoside A1 ), steroid (stigmasterol, β-sitosterol, and β-sitostenone), fatty acid esters, fatty alcohols, alkanes and others [26][27][28][29][30][31][32] . These bioactive compounds may be responsible for the biomedicinal effects reported many studies.…”

Section: Introductionmentioning

confidence: 99%

Agarwood Branch Ethanolic Extract Affects Expression of Apoptotic Genes in MCF-7 Breast Cancer Cells

Abbas¹,

Samsudin²,

Ishak³

et al. 2021

Prog Drug Discov Biomed Sci

View full text Add to dashboard Cite

Breast cancer is one of the most common death causes among women worldwide. Treatment is usually associated with chemically synthesized drugs with serious side effects which shifted the attention of cancer researchers towards development of natural product alternatives. Ethnopharmaceutical evidence showed that Aquilaria spp. have been used to treat a wide range of disorders. However, scientific evidence is still lacking to support and extend the traditional applications to cancer. This study aims to investigate differential gene expression (DEG) of MCF-7 cells treated with agarwood branch ethanolic extract (ABEE) to provide insights into its cell growth-inhibiting effects. Methods: cDNA synthesis from RNA of MCF-7 cells treated with the 8 µg/ml ABEE and DMSO-treated cells (control), respectively, were subjected to RT2 Profiler Array Human Cell Death Finder™ containing 84 genes related to cell death mechanism. Pathway analysis was carried out using the online KEGG Pathway tool. Results: 48 genes that met the threshold fold regulation cut-off of 2 and p < 0.05; 41 DEGs from the list were down-regulated, and 7 were up-regulated. Pathway analysis suggested ABEE may have caused apoptosis of MCF-7 cells through extrinsic and/or intrinsic apoptotic pathways, including activation of p53 that could be the first step towards apoptotic elimination of the cancer cells upon treatment of ABEE. Conclusion: Results obtained supported the growth inhibition effects of ABEE against MCF-7 cells that can serve as the basis for further work towards extending the use of agarwood as cancer therapeutics.

show abstract

Secondary Metabolites from the Leaves of Aquilaria sinensis

Cited by 7 publications

References 18 publications

Review: Secondary Metabolites of Aquilaria, a Thymelaeaceae Genus

Review: Secondary Metabolites of Aquilaria, a Thymelaeaceae Genus

Medicinal Effect Review of Agarwood Leaves From Aquilaria and Gyrinops Genera

Agarwood Branch Ethanolic Extract Affects Expression of Apoptotic Genes in MCF-7 Breast Cancer Cells

Contact Info

Product

Resources

About