Secondary Metabolites from the Marine Sponge Genus Phyllospongia

Zhang, Huawei; Dong, Menglian; Wang, Hong; Crews, Phillip

doi:10.3390/md15010012

Cited by 13 publications

(8 citation statements)

References 38 publications

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“…Marine organisms represent a broad source of potential sesterterpenoids. For example, genus Phyllospongia , one of the most common marine sponges, has been shown to be a prolific producer of various scalarane sesterterpenoids [ 6 ], and marine-derived fungi belong to the genus of Aspergillus produced sesterterpenoid ophiobolins [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

The Biological Activities of Sesterterpenoid-Type Ophiobolins

2017

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Ophiobolins (Ophs) are a group of tricarbocyclic sesterterpenoids whose structures contain a tricyclic 5-8-5 carbotricyclic skeleton. Thus far, 49 natural Ophs have been reported and assigned into A–W subgroups in order of discovery. While these sesterterpenoids were first characterized as highly effective phytotoxins, later investigations demonstrated that they display a broad spectrum of biological and pharmacological characteristics such as phytotoxic, antimicrobial, nematocidal, cytotoxic, anti-influenza and inflammation-promoting activities. These bioactive molecules are promising drug candidates due to the developments of their anti-proliferative activities against a vast number of cancer cell lines, multidrug resistance (MDR) cells and cancer stem cells (CSCs). Despite numerous studies on the biological functions of Ophs, their pharmacological mechanism still requires further research. This review summarizes the chemical structures, sources, and biological activities of the oph family and discusses its mechanisms and structure–activity relationship to lay the foundation for the future developments and applications of these promising molecules.

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Section: Introductionmentioning

confidence: 99%

The Biological Activities of Sesterterpenoid-Type Ophiobolins

2017

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“…In 2016–2017 several reviews covered general and/or specific areas of marine preclinical pharmacology: (a) marine pharmacology and marine pharmaceuticals: new marine natural products and relevant biological activities published in 2016 and 2017 [ 330 , 331 ]; chemistry and biology of guanidine natural products [ 332 , 333 ]; biological properties of secondary metabolites from sea hares of Aplysia genus [ 334 ]; alkynyl-containing peptides of marine cyanobacteria and molluscs [ 335 ]; bioactive cyanobacterial secondary metabolites for health [ 336 ]; biological active metabolites from marine-derived myxobacteria [ 337 ]; antimicrobial metabolites from the marine bacteria genus Pseudoalteromonas [ 338 ]; marine natural products from marine-derived Penicillium fungi [ 339 ]; biological activity of secondary metabolites from marine-algal-derived endophytic fungi [ 340 ]; pharmacological potential of fucosterol from marine algae [ 341 ]; pharmacological activities of Antarctic marine natural products [ 342 ]; bioactive acetylated triterpene glycosides from Holothuroidea in the past six decades [ 343 ]; terpenoids from octocorals of the genus Pachyclavularia [ 344 ]; bioactive marine natural products from sponges of the genus Hyrtios [ 345 ]; secondary metabolites from the marine sponge genus Phyllospongia [ 346 ]; discovery strategies of bioactive compounds synthetized by nonribosomal peptide synthetases and type-1 polyketide synthase derived from marine microbiomes [ 347 ]; developing natural product drugs: supply problems and how they have been overcome [ 348 ]; the global marine pharmaceutical pipeline in 2020: U.S. Food and Drug Administration-approved compounds and those in Phase I, II and III of clinical development ; (b) antimicrobial marine pharmacology: antimycobacterial metabolites from marine invertebrates [ 349 ]; antimicrobials from cnidarians [ 350 ]; (c) antiprotozoal and antimalarial marine pharmacology: natural products in drug discovery against neglected tropical diseases [ 351 ]; antimycobacterial natural products from marine Pseudopterogorgia elisabethae [ 352 ]; (d) immuno- and anti-inflammatory marine pharmacology: marine natural products inhibitors of neutrophil-associated inflammation [ 353 ]; (e) ...…”

Section: Reviews On Marine Pharmacology and Pharmaceuticalsmentioning

confidence: 99%

Marine Pharmacology in 2016–2017: Marine Compounds with Antibacterial, Antidiabetic, Antifungal, Anti-Inflammatory, Antiprotozoal, Antituberculosis and Antiviral Activities; Affecting the Immune and Nervous Systems, and Other Miscellaneous Mechanisms of Action

et al. 2021

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The review of the 2016–2017 marine pharmacology literature was prepared in a manner similar as the 10 prior reviews of this series. Preclinical marine pharmacology research during 2016–2017 assessed 313 marine compounds with novel pharmacology reported by a growing number of investigators from 54 countries. The peer-reviewed literature reported antibacterial, antifungal, antiprotozoal, antituberculosis, and antiviral activities for 123 marine natural products, 111 marine compounds with antidiabetic and anti-inflammatory activities as well as affecting the immune and nervous system, while in contrast 79 marine compounds displayed miscellaneous mechanisms of action which upon further investigation may contribute to several pharmacological classes. Therefore, in 2016–2017, the preclinical marine natural product pharmacology pipeline generated both novel pharmacology as well as potentially new lead compounds for the growing clinical marine pharmaceutical pipeline, and thus sustained with its contributions the global research for novel and effective therapeutic strategies for multiple disease categories.

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“… 2015 ; Zhang et al. 2017 ). Variety of species and environmental conditions significantly different than those in terrestrial ecosystems provided evolutionary pressure for the development of unique molecules that can be used for various pharmaceutical purposes, including the treatment of tumors and Alzheimer's disease (AD) (Blunt et al.…”

Section: Introductionmentioning

confidence: 99%

Further insight into the bioactivity of the freshwater sponge Ochridaspongia rotunda

Talevska

Pejin

Berić

et al. 2017

Pharmaceutical Biology

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Context: Bioprospection has become a dynamic scientific field that explores novel possibilities for the implementation of natural products in medicine and pharmacy. Compared to marine species from all kingdoms, freshwater species have been highly neglected.Objective: This work focuses on the screening of acetylcholinesterase inhibitory (AChE) and mutagenic activities of the acetone extract (obtained by maceration) of the freshwater sponge Ochridaspongia rotunda Arndt (Malawispongiidae) in vitro.Materials and methods: AChE inhibitory activity was evaluated both in liquid (five different concentrations of the extract, from 1 to 100 μg/mL) and in solid (seven different concentrations of the extract, from 0.5 to 10.0 μg) by methods well described in literature, while mutagenicity was estimated using the Ames test (four different concentrations of the extract, from 0.106 to 1.328 mg/plate).Results:Ochridaspongia rotunda acetone extract exhibited promising AChE inhibitory activity in a dose-dependent manner both in liquid (IC50 23.07 μg/mL) and in solid (1.50 μg). Furthermore, the Ames test revealed no sign of mutagenicity at any concentration tested. Its FTIR spectrum coupled with the positive Liebermann?Burchard, Salkowski and Zak color reactions (tests) indicated the presence of sterol compounds.Discussion and conclusion: The screened extract may inspire a search for novel anticholinesterase therapeutic agent(s) potentially used in the treatment of Alzheimer's disease. Further research will be directed toward its detailed chemical analysis along with addressing the issue of a real producer of the natural product(s) responsible for the AChE activity observed.

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Secondary Metabolites from the Marine Sponge Genus Phyllospongia

Cited by 13 publications

References 38 publications

The Biological Activities of Sesterterpenoid-Type Ophiobolins

The Biological Activities of Sesterterpenoid-Type Ophiobolins

Marine Pharmacology in 2016–2017: Marine Compounds with Antibacterial, Antidiabetic, Antifungal, Anti-Inflammatory, Antiprotozoal, Antituberculosis and Antiviral Activities; Affecting the Immune and Nervous Systems, and Other Miscellaneous Mechanisms of Action

Further insight into the bioactivity of the freshwater sponge Ochridaspongia rotunda

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