Secondary Metabolites of The Endophytic Fungus Alternaria alternata JS0515 Isolated from Vitex rotundifolia and Their Effects on Pyruvate Dehydrogenase Activity

Lee, Changyeol; Li, Wei; Bang, Sunghee; Kang, Nam‐Young; Kim, Soonok; Kim, Tae-In; Go, Younghoon; Shim, Sang Hee

doi:10.3390/molecules24244450

Cited by 14 publications

(11 citation statements)

References 48 publications

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“…These natural mycotoxin products identified at level 2 are mainly novel and modified Alternaria mycotoxins. According to publications and database, , ALT, altenusin (ALU), desmethylaltenusin (DMA), desmethyldehydroaltenusin (DMDA), and altertoxin I were identified according to precursor and product ions, retention time, accuracy mass, and elementary composition. In our preliminary examination, Alternaria mycotoxins, secondary metabolites produced by Alternaria spp., exhibited a high response in negative ion mode.…”

Section: Resultsmentioning

confidence: 99%

Visible Post-Data Analysis Protocol for Natural Mycotoxin Production

Lin

et al. 2020

J. Agric. Food Chem.

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Fungal natural products are routinely analyzed using target detection protocols by comparing to commercial standards. However, discovery of new products suffers from a lack of high-throughput analytical techniques. Post-data process techniques have become popular tools for natural product confirmations and mycotoxin family analysis. In this work, a visible postdata process procedure with MZmine, GNPS, and Xcalibur was used for efficient analysis of high-resolution mass spectrometry. Conjugated products were screened with an optimized diagnostic fragmentation filtering module in MZmine and further confirmed with Xcalibur by comparing to unconjugated commercial standards. MS/MS spectral data were processed and used to establish a feature based on a molecular networking map in GNPS (Global Natural Products Social Molecular Networking; https://gnps.ucsd. edu), for visualization of fungal natural product families. The results demonstrate the potential of combining MZmine-, GNPS-, and Xcalibur-based methods for visible analysis of fungal natural products.

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Section: Resultsmentioning

confidence: 99%

Visible Post-Data Analysis Protocol for Natural Mycotoxin Production

Lin

et al. 2020

J. Agric. Food Chem.

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“…The enantiomer (+)-(12S,13R)-3, named alternatiol, has been isolated from Alternaria alternata JS0515 in 2019. 27 In this study, (−)-(12R,13S)-3 was reported for the first time and designated as (−)-alternatiol.…”

Section: ■ Results and Discussionmentioning

confidence: 84%

“…As shown in Figure C, the absolute configuration of each isomer was determined by ECD calculation. The enantiomer (+)-(12 S ,13 R )- 3 , named alternatiol, has been isolated from Alternaria alternata JS0515 in 2019 . In this study, (−)-(12 R ,13 S )- 3 was reported for the first time and designated as (−)-alternatiol.…”

Section: Resultsmentioning

confidence: 86%

Enantiomeric Dibenzo-α-Pyrone Derivatives from Alternaria alternata ZHJG5 and Their Potential as Agrochemicals

Zhao

Tian

et al. 2020

J. Agric. Food Chem.

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Three pairs of enantiomeric dibenzo-α-pyrone derivatives (1−3) including two pairs of new racemates (±)-alternaone A ( 1) and (±)-alternaone B (2) and one new enantiomer (−)-alternatiol (3), together with five known compounds (4−8) were isolated from the fungus Alternaria alternata ZHJG5. Their structures were confirmed by spectroscopic data and single-crystal X-ray diffraction analysis. All enantiomers were separated via chiral high-performance liquid chromatography, with their configurations determined by electronic circular dichroism calculation. Biogenetically, a key epoxy-rearrangement step was proposed for the formation of skeletons in 1−3; (+) 1, (−)-1, and 5 presented moderate antibacterial inhibition on phytopathogenic bacteria Xanthomonas oryzae pv. oryzae and Xanthomonas oryzae pv. oryzicola. In the antifungal test, compounds 7 and 8 showed a moderate protective effect against Botrytis cinerea in vivo.

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“…Perylenequinones 2 , 3 , 8 , and 15 showed excellent activities for inhibition of α-glucosidase in the range of 12–166 mM, being more potent than the positive control acarbose (427) . On the other hand, PQ 2 increased the activity of pyruvate dehydrogenase (PDH) in AD-293 human embryonic kidney cells (27.82 mM), and suppression of PDH activity is associated with various metabolic disorders such as obesity, diabetes, and cancer …”

Section: Biological Propertiesmentioning

confidence: 99%

Naturally Occurring Partially Reduced Perylenequinones from Fungi

et al. 2022

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This Review provides a critical analysis of the literature covering the naturally occurring partially reduced perylenequinones (PQs) from fungi without carbon substituents (which can be named class A perylenequinones) and discusses their structures, stereochemistry, biosynthesis, and biological activities as appropriate. Perylenequinones are natural pigments with a perylene skeleton produced by certain fungi, aphids, some plants, and animal species. These compounds display several biological activities, e.g., antimicrobial, anti-HIV, photosensitizers, cytotoxic, and phytotoxic. It describes 36 fungal PQs and cites 81 references, covering from 1956 to August 2022.

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Secondary Metabolites of The Endophytic Fungus Alternaria alternata JS0515 Isolated from Vitex rotundifolia and Their Effects on Pyruvate Dehydrogenase Activity

Cited by 14 publications

References 48 publications

Visible Post-Data Analysis Protocol for Natural Mycotoxin Production

Visible Post-Data Analysis Protocol for Natural Mycotoxin Production

Enantiomeric Dibenzo-α-Pyrone Derivatives from Alternaria alternata ZHJG5 and Their Potential as Agrochemicals

Naturally Occurring Partially Reduced Perylenequinones from Fungi

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