Secondary Osteoporosis: A Still Neglected Condition

Favero, V. Del; Eller-Vainicher, Cristina; Chiodini, Iacopo

doi:10.3390/ijms24108558

Cited by 3 publications

(1 citation statement)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Osteoporosis can generally occur as primary osteoporosis, which results from aging and decreasing sex hormone levels [ 14 ]. Secondary osteoporosis, on the other hand, occurs due to other primary diseases [ 15 , 16 ]. These primary diseases resulting in secondary osteoporosis include numerous rheumatic disorders such as rheumatoid arthritis or spondylarthritis, endocrinological diseases such as hyperparathyroidism, or diseases requiring glucocorticoid therapy [ 4 , 5 , 17 , 18 , 19 , 20 ].…”

Section: Introductionmentioning

confidence: 99%

Trabecular Bone Score Significantly Influences Treatment Decisions in Secondary Osteoporosis

Al-Hashimi

Ohrndorf

Gaber

et al. 2023

JCM

View full text Add to dashboard Cite

The trabecular bone score (TBS) can be determined in addition to the Dual Energy X-ray Absorptiometry (DXA) for bone mineral density (BMD) measurement to diagnose, evaluate, and stratify bone loss and decide on appropriate treatment in patients at risk. Especially in patients with secondary osteoporosis, TBS detects restricted bone quality. To investigate the influence of an additional evaluation of TBS on patients’ treatment strategy decisions, we enrolled 292 patients, with a high proportion of patients with secondary osteoporosis, from one outpatient unit over one year. Patients eligible for BMD measurement had the option to opt-in for TBS measurement. We analyzed demographic data, leading diagnoses, bone metabolism parameters, and results of BMD and TBS measurements. More than 90% of patients consented to TBS measurement. TBS measurement influenced the decision in approximately 40% of patients with a treatment indication for anti-osteoporotic drugs. We demonstrate that depending on the underlying disease/risk spectrum, 21–25.5% of patients had an unremarkable BMD measurement with poor bone quality shown in the TBS measurement. In patients with secondary osteoporosis, the use of TBS supplementary to DXA seems useful to better assess fracture risk and, thus, to initiate therapy for osteoporosis in these patients in time.

show abstract

Section: Introductionmentioning

confidence: 99%

Trabecular Bone Score Significantly Influences Treatment Decisions in Secondary Osteoporosis

Al-Hashimi

Ohrndorf

Gaber

et al. 2023

JCM

View full text Add to dashboard Cite

show abstract

Pharmacology and mechanisms of apigenin in preventing osteoporosis

Lin,

Yincang,

Jiazhe

et al. 2024

Front. Pharmacol.

View full text Add to dashboard Cite

Osteoporosis (OP) stands as the most prevalent systemic skeletal condition associated with aging. The current clinical management of OP predominantly depends on anti-resorptive and anabolic agents. Nevertheless, prolonged use of some of these medications has been observed to reduce efficacy and elevate adverse effects. Given the necessity for sustained or even lifelong treatment of OP, the identification of drugs that are not only effective but also safe and cost-efficient is of utmost significance. As disease treatment paradigms continue to evolve and recent advancements in OP research come to light, certain plant-derived compounds have emerged, presenting notable benefits in the management of OP. This review primarily explores the pharmacological properties of apigenin and elucidates its therapeutic mechanisms in the context of OP. The insights provided herein aspire to offer a foundation for the judicious use of apigenin in forthcoming research, particularly within the scope of OP.

show abstract

Sirt1: An Increasingly Interesting Molecule with a Potential Role in Bone Metabolism and Osteoporosis

Chen,

Xiao,

Liu

et al. 2024

Biomolecules

View full text Add to dashboard Cite

Osteoporosis (OP) is a common metabolic bone disease characterized by low bone mass, decreased bone mineral density, and degradation of bone tissue microarchitecture. However, our understanding of the mechanisms of bone remodeling and factors affecting bone mass remains incomplete. Sirtuin1 (SIRT1) is a nicotinamide adenine dinucleotide-dependent deacetylase that regulates a variety of cellular metabolisms, including inflammation, tumorigenesis, and bone metabolism. Recent studies have emphasized the important role of SIRT1 in bone homeostasis. This article reviews the role of SIRT1 in bone metabolism and OP and also discusses therapeutic strategies and future research directions for targeting SIRT1.

show abstract

Secondary Osteoporosis: A Still Neglected Condition

Abstract: The condition of “secondary osteoporosis” is defined as a bone loss that results from specific well-defined clinical disorders [...]

Cited by 3 publications

References 16 publications

Trabecular Bone Score Significantly Influences Treatment Decisions in Secondary Osteoporosis

Trabecular Bone Score Significantly Influences Treatment Decisions in Secondary Osteoporosis

Pharmacology and mechanisms of apigenin in preventing osteoporosis

Sirt1: An Increasingly Interesting Molecule with a Potential Role in Bone Metabolism and Osteoporosis

Contact Info

Product

Resources

About