‘Secondary prevention’ against female HPV infection: literature review of the role of carrageenan

Calagna, Gloria; Maranto, Marianna; Paola, C. De; Capra, Giuseppina; Perino, Antonino; Chiàntera, Vito; Cucinella, Gaspare

doi:10.1080/14787210.2020.1770082

Cited by 20 publications

(15 citation statements)

References 35 publications

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“…Cervical cancer screening service utilization is recommended for effective methods for the prevention and early detection of cervical cancer [8]. Thus, evidence support the possibility to use specific biomarkers to identify early-stage cervical cancer (precancerous cervical lesion) which offer a better prognosis to the patients [9][10][11]. However, global evidence shows that the utilization of screening for prevention is very poor in developing countries.…”

Section: Introductionmentioning

confidence: 99%

Determinants of cervical cancer screening service utilization among women attending healthcare services in Amhara region referral hospitals: a case–control study

et al. 2022

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Background Cervical cancer is the second leading cause of cancer-related death and one of the top 20 causes of death among women in Ethiopia. Cervical cancer screening service has a vital value to reduce morbidity and mortality. Even though cervical cancer screening service utilization in Ethiopia is unacceptably low, its determinant factors were not well studied in the study area. Hence, this study was aimed at filling this information gap. This study aimed to identify determinants of cervical cancer screening service utilization among women attending healthcare services in Amhara region referral hospitals, Ethiopia. Methods Hospital-based case–control study was conducted among 441 women (147 cases and 294 controls) from May to July 2021. Cases were included consecutively and controls were selected using a systematic random sampling technique from the randomly selected hospitals. A pretested interviewer-administered questionnaire was used to collect the data from respondents. The data were entered into Epi data version 4.6 and exported to SPSS version 25 for analysis. Bivariable and multivariable logistic regression analysis was employed. Adjusted odds ratio with its 95% confidence interval and p value < 0.05 were used to estimate the strength and significance of the association. Result A total of 147 cases and 294 controls were enrolled in this study. Women with 30–39 years-old [AOR = 2.3; 95% CI 1.21, 4.68] and 40–49 years-old [AOR = 4.4 95% CI 1.97, 10.12], urban residence [AOR = 2.6; 95% CI 1.36, 5.21], secondary education [AOR = 4.4; 95% CI 2.18, 8.87] and diploma and above [AOR = 2.0; 95% CI: 1.05, 4.59], ever gave birth [AOR = 9.4; 95% CI 4.92, 18.26], having multiple sexual partners [AOR = 2.8; 95% CI 1.60, 5.03], good knowledge towards cervical cancer screening [AOR = 3.6; 95% CI 2.07, 6.43] and positive attitude on cervical cancer screening [AOR = 2.0, 95% CI 1.20, 3.70] were significant determinants of cervical cancer screening service utilization. Conclusion In this study, age (30–39 and 40–49), urban residence, secondary education, ever gave birth, good knowledge of cervical cancer screening, positive attitude towards cervical cancer screening, and having multiple sexual partners were significant determinants of cervical cancer screening service utilization. There is a need to strengthen the policy and health education on safe sexual practices and healthy lifestyles through information dissemination and communication to scale up screening service utilization.

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Section: Introductionmentioning

confidence: 99%

Determinants of cervical cancer screening service utilization among women attending healthcare services in Amhara region referral hospitals: a case–control study

et al. 2022

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“…It is composed of alternating units of D-galactose and 3,6-anhydrogalactose (3,6-ag) linked with α-1,3 and β-1,4 glycosides. According to the forms of sulphate binding in them, they can be classified as K-type (Kappa), I-type (Iota) and L-type (Lambda) [164]. Carrageenan is extensively used in the pharmaceutical industry due to its gelling, thickening, and emulsifying properties.…”

Section: Carrageenanmentioning

confidence: 99%

Marine Polysaccharides for Wound Dressings Application: An Overview

et al. 2021

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Wound dressings have become a crucial treatment for wound healing due to their convenience, low cost, and prolonged wound management. As cutting-edge biomaterials, marine polysaccharides are divided from most marine organisms. It possesses various bioactivities, which allowing them to be processed into various forms of wound dressings. Therefore, a comprehensive understanding of the application of marine polysaccharides in wound dressings is particularly important for the studies of wound therapy. In this review, we first introduce the wound healing process and describe the characteristics of modern commonly used dressings. Then, the properties of various marine polysaccharides and their application in wound dressing development are outlined. Finally, strategies for developing and enhancing marine polysaccharide wound dressings are described, and an outlook of these dressings is given. The diverse bioactivities of marine polysaccharides including antibacterial, anti-inflammatory, haemostatic properties, etc., providing excellent wound management and accelerate wound healing. Meanwhile, these biomaterials have higher biocompatibility and biodegradability compared to synthetic ones. On the other hand, marine polysaccharides can be combined with copolymers and active substances to prepare various forms of dressings. Among them, emerging types of dressings such as nanofibers, smart hydrogels and injectable hydrogels are at the research frontier of their development. Therefore, marine polysaccharides are essential materials in wound dressings fabrication and have a promising future.

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“…The study showed that carrageenan treatment in the low ng/mL range resulted in 50% inhibition [108]. Extracted from red algae, carrageenan has also been shown to inhibit HSV and HIV infections in vitro [109]. The primary mode by which carrageenan blocks HPV infection is by directly binding to the viral capsid, thereby blocking its interactions with cell surface HSPG attachment factors [109].…”

Section: Naturally Derived Sulfated Polysaccharidesmentioning

confidence: 99%

“…Extracted from red algae, carrageenan has also been shown to inhibit HSV and HIV infections in vitro [109]. The primary mode by which carrageenan blocks HPV infection is by directly binding to the viral capsid, thereby blocking its interactions with cell surface HSPG attachment factors [109]. Carrageenan was also shown to have an HSPGindependent effect, either by blocking interactions with cellular proteins involved in the internalization process or by preventing conformational changes to the capsid that are necessary for infectious internalization [36].…”

Section: Naturally Derived Sulfated Polysaccharidesmentioning

confidence: 99%

“…Several groups explored the potential of carrageenan-based lubricants/microbicides in inhibiting HPV infection [109]. A study by Roberts et al proved carrageenan's in vivo application, where two commercial carrageenan-containing lubricants (Divine 9 and BIOglide) decreased HPV16-PsV infection in a mouse model [36].…”

Section: Naturally Derived Sulfated Polysaccharidesmentioning

confidence: 99%

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Advances in Targeting HPV Infection as Potential Alternative Prophylactic Means

Carse

Bergant

Schäfer

2021

IJMS

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Infection by oncogenic human papillomavirus (HPV) is the primary cause of cervical cancer and other anogenital cancers. The majority of cervical cancer cases occur in low- and middle- income countries (LMIC). Concurrent infection with Human Immunodeficiency Virus (HIV) further increases the risk of HPV infection and exacerbates disease onset and progression. Highly effective prophylactic vaccines do exist to combat HPV infection with the most common oncogenic types, but the accessibility to these in LMIC is severely limited due to cost, difficulties in accessing the target population, cultural issues, and maintenance of a cold chain. Alternative preventive measures against HPV infection that are more accessible and affordable are therefore also needed to control cervical cancer risk. There are several efforts in identifying such alternative prophylactics which target key molecules involved in early HPV infection events. This review summarizes the current knowledge of the initial steps in HPV infection, from host cell-surface engagement to cellular trafficking of the viral genome before arrival in the nucleus. The key molecules that can be potentially targeted are highlighted, and a discussion on their applicability as alternative preventive means against HPV infection, with a focus on LMIC, is presented.

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‘Secondary prevention’ against female HPV infection: literature review of the role of carrageenan

Cited by 20 publications

References 35 publications

Determinants of cervical cancer screening service utilization among women attending healthcare services in Amhara region referral hospitals: a case–control study

Determinants of cervical cancer screening service utilization among women attending healthcare services in Amhara region referral hospitals: a case–control study

Marine Polysaccharides for Wound Dressings Application: An Overview

Advances in Targeting HPV Infection as Potential Alternative Prophylactic Means

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