S U M M A R YIn recent years, the prevalence of hookah smoking has increased worldwide, particularly in young people, which may have potentially serious consequences for their health. The aim of this study was to examine the factors associated with the consumption of hookah by high school students.The present study was conducted in the city of Novi Pazar, and students aged 17-19 years attending the following high schools were included: Medical School, Grammar School, Economic-Commerce School and Catering School. The study was designed as a case-control study. The cases were students who consumed nargile, while the control group consisted of students who had never smoked nargile. A special questionnaire was constructed for the purpose of this research, which was used to evaluate the opinions of adolescents on the consumption of nargile.Our research included a total of 270 seniors in high schools in Novi Pazar. The average age of the students was 18 years. The most important factors that may contribute to start using nargile were: previous consumption of nargile by older family members, divorced parents, and active smoking of cigarettes by other family members. Most students emphasized that hookah smoking is socially unacceptable form of behavior. Also, hookah smoker were neither more attractive nor popular.Nargile consumption is more common by adolescents whose parents are divorced, as well as by adolescents whose family members are smoking nargile or tobacco. The most common reason for nargile consumption among adolescents is a desire for relaxation.