Secreted Monocyte miR-27a Causes Hypertension by Reducing Mas Receptor Expression and Function in the Artery

Zou, Xingxing; Wang, J.; Chen, C.; José, Pedro A.; Zeng, Chunyu

doi:10.1016/j.jash.2016.06.010

Cited by 3 publications

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“…Furthermore, dysregulation of some of these miRs frequently correlates with outcome of cancer and is predictive for refractory therapy, 59-61 development or relapse of disease before clinical manifestation, 62 and poor prognosis. 50 , 51 , 63 Additionally, it may lead to hypertension 64 and is also indicative of increased risk of death upon chronic heart disease 65 or post infarction. 66 However, further experiments are needed to prove that methylation changes affect miR and target gene expression, and thus represent a prominent mechanism for PM-associated diseases.…”

Section: Discussionmentioning

confidence: 99%

Disease relevant modifications of the methylome and transcriptome by particulate matter (PM_2.5) from biomass combustion

et al. 2017

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Exposure to particulate matter (PM) is recognized as a major health hazard, but molecular responses are still insufficiently described. We analyzed the epigenetic impact of ambient PM2.5 from biomass combustion on the methylome of primary human bronchial epithelial BEAS-2B cells using the Illumina HumanMethylation450 BeadChip. The transcriptome was determined by the Affymetrix HG-U133 Plus 2.0 Array. PM2.5 induced genome wide alterations of the DNA methylation pattern, including differentially methylated CpGs in the promoter region associated with CpG islands. Gene ontology analysis revealed that differentially methylated genes were significantly clustered in pathways associated with the extracellular matrix, cellular adhesion, function of GTPases, and responses to extracellular stimuli, or were involved in ion binding and shuttling. Differential methylations also affected tandem repeats. Additionally, 45 different miRNA CpG loci showed differential DNA methylation, most of them proximal to their promoter. These miRNAs are functionally relevant for lung cancer, inflammation, asthma, and other PM-associated diseases. Correlation of the methylome and transcriptome demonstrated a clear bias toward transcriptional activation by hypomethylation. Genes that exhibited both differential methylation and expression were functionally linked to cytokine and immune responses, cellular motility, angiogenesis, inflammation, wound healing, cell growth, differentiation and development, or responses to exogenous matter. Disease ontology of differentially methylated and expressed genes indicated their prominent role in lung cancer and their participation in dominant cancer related signaling pathways. Thus, in lung epithelial cells, PM2.5 alters the methylome of genes and noncoding transcripts or elements that might be relevant for PM- and lung-associated diseases.

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Section: Discussionmentioning

confidence: 99%

Disease relevant modifications of the methylome and transcriptome by particulate matter (PM_2.5) from biomass combustion

et al. 2017

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Extracellular Vesicles in Essential Hypertension: Hidden Messengers

et al. 2020

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Mas receptor: a potential strategy in the management of ischemic cardiovascular diseases

Molaei

Hayes

et al. 2023

Cell Cycle

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Secreted Monocyte miR-27a Causes Hypertension by Reducing Mas Receptor Expression and Function in the Artery

Cited by 3 publications

References 0 publications

Disease relevant modifications of the methylome and transcriptome by particulate matter (PM_2.5) from biomass combustion

Disease relevant modifications of the methylome and transcriptome by particulate matter (PM_2.5) from biomass combustion

Extracellular Vesicles in Essential Hypertension: Hidden Messengers

Mas receptor: a potential strategy in the management of ischemic cardiovascular diseases

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Secreted Monocyte miR-27a Causes Hypertension by Reducing Mas Receptor Expression and Function in the Artery

Cited by 3 publications

References 0 publications

Disease relevant modifications of the methylome and transcriptome by particulate matter (PM2.5) from biomass combustion

Disease relevant modifications of the methylome and transcriptome by particulate matter (PM2.5) from biomass combustion

Extracellular Vesicles in Essential Hypertension: Hidden Messengers

Mas receptor: a potential strategy in the management of ischemic cardiovascular diseases

Contact Info

Product

Resources

About

Disease relevant modifications of the methylome and transcriptome by particulate matter (PM_2.5) from biomass combustion

Disease relevant modifications of the methylome and transcriptome by particulate matter (PM_2.5) from biomass combustion