Secretin Inactivating Enzyme in Liver.

Bridgwater, Anna B.; Kuroyanagi, Yasuo; Chiles, T.; Necheles, H.

doi:10.3181/00379727-110-27670

Cited by 15 publications

(4 citation statements)

References 1 publication

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“…The kidneys may also be involved in the elimination of the peptide hormones. Bridgewater et al [2] found a 'secretin-inactivating enzyme' in the liver and the kidneys. In addition, SvatoS and Queisnerovà [33] showed a cholecystokinin-like activity (uropancreozymin) in the urine.…”

mentioning

confidence: 99%

Studies on the Elimination of Secretin and Cholecystokinin with Regard to the Kinetics of Exocrine Pancreatic Secretion

Lehnert¹,

Stahlheber²,

Forell³

et al. 1974

Digestion

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Studies were performed on 72 anesthetized mongrel dogs. Upon injection or infusion of secretin into the portal vein, the pancreatic volume and bicarbonate response was found to be significantly smaller than following administration into the femoral vein, but only when low doses of secretin (0.25 clin U/kg/h or smaller) were applied. No difference was observed in pancreatic protein and enzyme secretion after cholecystokinin, when both high and low doses were applied to the portal or femoral vein. The injection of secretin and cholecystokinin into the renal artery causes a loss of biological activity of 75 and 60%, respectively, as compared to femoral administration. Ligature of the blood vessels of both kidneys resulted in an increase in the biological activity of secretin of 80% and of cholecystokinin of 50%. The slopes of the flow rate curves determined upon secretin injection were smaller after ligature of the renal blood vessels. The biological half-life of secretin increased from an average of 2.9 to 4.8 min. These results indicate that the kidneys play a role in the catabolism of exogenous secretin and cholecystokinin, whereas the blood and the liver (at least for cholecystokinin) seem to be of small importance.

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mentioning

confidence: 99%

Studies on the Elimination of Secretin and Cholecystokinin with Regard to the Kinetics of Exocrine Pancreatic Secretion

Lehnert¹,

Stahlheber²,

Forell³

et al. 1974

Digestion

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“…It is a known fact that secretin is metabolized by the liver (Bridgwater et al 1962). In continuous intravenous infusion, infused secretin must have been metabolized successively, and consequently the level of secretin in the blood must have approached a plateau gradually.…”

Section: Discussionmentioning

confidence: 99%

Continuous Secretin Infusion with Pancreozymin Pretreatment as a Pancreatic Function Test

Takebe

Koizumi

Yamagata

1976

Tohoku J. Exp. Med.

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“…Until recently, most studies on the elimination of secretin have been based on bicarbonate and water secretion by the pancreas [16][17][18]. Although results are variable, the kidney and liver are probably the major sites of secretin degradation.…”

Section: Secretinmentioning

confidence: 99%

Effect of renal failure on gastrointestinal hormones

Hansky

1979

World j. surg.

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The development of sensitive, specific radioimmunoassays has enabled study of gastrointestinal hormones in various disease states. Since the findings that the kidney catabolizes gastrin and serum gastrin is elevated in chronic renal failure and in anephric patients, other hormones have been studied in these conditions. Cholecystokinin (CCK), GIP, glucagon, and secretin are all elevated in chronic renal failure and the degree of elevation is correlated with the severity of renal impairment. Hemodialysis leads to a lowering of gastrin and GIP but has no effect on CCK or glucagon. Levels of gastrin return to normal following successful renal transplantation. The role that these elevated hormone levels play in altered gastrointestinal function in renal failure is uncertain.

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Secretin Inactivating Enzyme in Liver.

Cited by 15 publications

References 1 publication

Studies on the Elimination of Secretin and Cholecystokinin with Regard to the Kinetics of Exocrine Pancreatic Secretion

Studies on the Elimination of Secretin and Cholecystokinin with Regard to the Kinetics of Exocrine Pancreatic Secretion

Continuous Secretin Infusion with Pancreozymin Pretreatment as a Pancreatic Function Test

Effect of renal failure on gastrointestinal hormones

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