Secretion of apoB- and apoA-I-containing lipoproteins by chick kidney

Tarugi, Patrizia; Ballarini, G.; Pinotti, B.; Franchini, Antonella; Ottaviani, Enzo; Calandra, Sebastiano

doi:10.1016/s0022-2275(20)32562-1

Cited by 27 publications

(3 citation statements)

References 42 publications

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“…In the current study, we demonstrated that the apoB mRNA is highly expressed in the liver of laying Taiwan Country chickens similar to what was reported by Dixon et al (1992) in Leghorn chickens. The results suggest that in the chicken, liver is the major site for production of apoB, although some apoB synthesis can be found in the kidney (Tarugi et al, 1998).…”

Section: Discussionmentioning

confidence: 91%

The Expression of Genes Related to Egg Production in the Liver of Taiwan Country Chickens

Ding¹,

Ko²,

Ou³

et al. 2008

Asian Australas. J. Anim. Sci

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The purpose of this study was to detect expression of genes related to egg production in Taiwan Country chickens by suppression subtractive hybridization. Liver samples of mRNA extraction from two Taiwan Country chicken strains (L2 and B), originated from the same population but with very distinct egg production rates after long-term selection for egg and meat production respectively. Two-way subtraction was performed. The hepatic cDNA from the low egg production chickens (B) was subtracted from the hepatic cDNA from the high egg production strain (L2). The reversed subtraction (L2 from B) was also performed. The resulting differentially expressed gene fragments were cloned and sequenced. We sequenced 288 clones from the forward subtraction and 96 clones from the reverse subtraction. These genes were subjected to further screening to confirm the differential expression between the two genetic breeds of chickens. The apolipoprotein B (apoB) was expressed to a greater extent in the liver of the L2 than in the B line chickens. The 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase (PURH) was expressed to a greater extent in the liver of the B than in the L2 strain chickens. We demonstrated that both apoB and PURH were more highly expressed in the liver than that in other tissues (muscle, ovary, and oviduct) in laying Taiwan Country chickens. Taken together, these data suggest that after the selection for egg production, expression of apoB and PURH genes were also changed. Whether the changed expression of these genes is directly related to egg production is not known, but these two genes may be useful markers for egg laying performance in Taiwan Country chickens.

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Section: Discussionmentioning

confidence: 91%

The Expression of Genes Related to Egg Production in the Liver of Taiwan Country Chickens

Ding¹,

Ko²,

Ou³

et al. 2008

Asian Australas. J. Anim. Sci

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“…Initially, it was believed that E 2 did not play any role in the synthesis of ApoB in the kidney or intestine (Kirchgessner et al, 1987;Lazier et al, 1994), while it was shown to directly control the production of ApoVLDL-II in the embryonic kidney (Lazier et al, 1994). However, the hen's kidney produces generic VLDL and HDL (Bensadoun and Rothfeld, 1972;Tarugi et al, 1998), with the generic VLDL secreted by cells of the proximal tubules. Thus, generic VLDL from the kidney during the laying cycle was proposed to provide the necessary energy to tissues evaded by VLDLy (Walzem et al, 1999).…”

Section: Activation Of the Kidneymentioning

confidence: 99%

The Diverse Roles of 17β-Estradiol in Non-Gonadal Tissues and Its Consequential Impact on Reproduction in Laying and Broiler Breeder Hens

2022

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Estradiol-17β (E2) has long been studied as the primary estrogen involved in sexual maturation of hens. Due to the oviparous nature of avian species, ovarian production of E2 has been indicated as the key steroid responsible for activating the formation of the eggshell and internal egg components in hens. This involves the integration and coordination between ovarian follicular development, liver metabolism and bone physiology to produce the follicle, yolk and albumen, and shell, respectively. However, the ability of E2 to be synthesized by non-gonadal tissues such as the skin, heart, muscle, liver, brain, adipose tissue, pancreas, and adrenal glands demonstrates the capability of this hormone to influence a variety of physiological processes. Thus, in this review, we intend to re-establish the role of E2 within these tissues and identify direct and indirect integration between the control of reproduction, metabolism, and bone physiology. Specifically, the sources of E2 and its activity in these tissues via the estrogen receptors (ERα, ERβ, GPR30) is described. This is followed by an update on the role of E2 during sexual differentiation of the embryo and maturation of the hen. We then also consider the implications of the recent discovery of additional E2 elevations during an extended laying cycle. Next, the specific roles of E2 in yolk formation and skeletal development are outlined. Finally, the consequences of altered E2 production in mature hens and the associated disorders are discussed. While these areas of study have been previously independently considered, this comprehensive review intends to highlight the critical roles played by E2 to alter and coordinate physiological processes in preparation for the laying cycle.

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“…Most apoA-I is synthesized in the liver and intestine, although small amounts of apoA-I are produced in avian nerve tissue (10) and kidney (11). ApoA-I is translated as a preproprotein (12) and, after cleavage of the 18-amino acid signal peptide, the proprotein is secreted into the plasma, where the 6-amino acid propeptide is removed by cleavage through an unidentified metalloprotease (13).…”

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confidence: 99%

Deletion of the propeptide of apolipoprotein A-I reduces protein expression but stimulates effective conversion of preβ-high density lipoprotein to α-high density lipoprotein

Sviridov

Pyle

Jauhiainen

et al. 2000

Journal of Lipid Research

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The properties of the mature and pro-forms of recombinant apolipoprotein A-I (apoA-I) were compared with those of apoA-I isolated from human plasma. When the synthesis and secretion of pro-and mature forms of apoA-I from a baculovirus/insect cell expression system were compared in parallel experiments, the amount of the pro-form of apoA-I synthesized and secreted was severalfold higher than that of the mature form of apoA-I. A comparison of the properties of the pro-and mature forms of recombinant apoA-I and human plasma apoA-I showed no difference between all three in their secondary structure, their ability to self-associate, lipid-binding capacity, lecithin: cholesterol acyltransferase activation, and binding to the phospholipid transfer protein. The properties of reconstituted high density lipoprotein (HDL) particles formed from the proteins and their ability to promote cholesterol and phospholipid efflux from human skin fibroblasts were also similar. However, their ability to bind to plasma HDL subfractions differed, because twice as much proapoA-I associated with pre ␤ 1 -HDL and pre ␤ 2 -HDL subfractions compared with both mature recombinant and plasma apoA-I. Correspondingly, the amount of proapoA-I in ␣ -HDL subfractions, especially in ␣ 1 -HDL and ␣ 2 -HDL, was decreased. We conclude that while the propeptide of apoA-I is required for the effective synthesis and secretion of apoA-I, cleavage of this peptide is a requisite for the effective interconversion of HDL subfractions. -Sviridov, D., L. E. Pyle, M. Jauhiainen, C. Ehnholm, and N. H. Fidge. Deletion of the propeptide of apolipoprotein A-I reduces protein expression, but stimulates effective conversion of pre ␤ -high density lipoprotein to ␣ -high density lipoprotein.

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Secretion of apoB- and apoA-I-containing lipoproteins by chick kidney

Cited by 27 publications

References 42 publications

The Expression of Genes Related to Egg Production in the Liver of Taiwan Country Chickens

The Expression of Genes Related to Egg Production in the Liver of Taiwan Country Chickens

The Diverse Roles of 17β-Estradiol in Non-Gonadal Tissues and Its Consequential Impact on Reproduction in Laying and Broiler Breeder Hens

Deletion of the propeptide of apolipoprotein A-I reduces protein expression but stimulates effective conversion of preβ-high density lipoprotein to α-high density lipoprotein

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