Secretion of brain natriuretic peptide in patients with aneurysmal subarachnoid haemorrhage

Berendes, Elmar; Walter, Michael; Cullen, Paul; Prien, T.; Aken, Hugo Van; Horsthemke, Jürgen; Schulte, Manfred; Wild, K. von; Scherer, R.

doi:10.1016/s0140-6736(96)08093-2

Cited by 337 publications

(244 citation statements)

References 21 publications

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“…In other studies with longer observation periods, hyponatremia developed frequently after SAH [1,23] and was associated with negative sodium balance [1,24] and fluid balance [25]. The authors found almost uniformly increased ANP and/or BNP concentrations and delayed activation of the renin-aldosterone axis [1,2,24].…”

Section: Discussionmentioning

confidence: 83%

“…Serum sodium concentration and fluid balance are frequently abnormal in patients after subarachnoid hemorrhage (SAH) [1,2], with dysnatremia causing morbidity in patients with SAH [3][4][5]. Moreover, in other critically ill or emergency patient populations, both severe hyper-and hyponatremia are associated with persistent neurological deficits and high mortality [6][7][8].…”

Section: Introductionmentioning

confidence: 99%

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Randomized, Double-Blind Trial of the Effect of Fluid Composition on Electrolyte, Acid–Base, and Fluid Homeostasis in Patients Early After Subarachnoid Hemorrhage

et al. 2012

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Background Hyper-and hyponatremia are frequently observed in patients after subarachnoidal hemorrhage, and are potentially related to worse outcome. We hypothesized that the fluid regimen in these patients is associated with distinct changes in serum electrolytes, acid-base disturbances, and fluid balance. Methods Thirty-six consecutive patients with SAH were randomized double-blinded to either normal saline and hydroxyethyl starch dissolved in normal saline (Voluven Ò ; saline) or balanced crystalloid and colloid solutions (Ringerfundin Ò and Tetraspan Ò ; balanced, n = 18, each) for 48 h. Laboratory samples and fluid balance were evaluated at baseline and at 24 and 48 h. Results Age [57 ± 13 years (mean ± SD; saline) vs. Conclusions Treatment with saline-based fluids resulted in a greater number of patients with hyperchloremia, hyperosmolality, and positive fluid balance >1,500 mL early after SAH, while administration of balanced solutions did not cause more frequent hyponatremia or hypo-osmolality. These results should be confirmed in larger studies.

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Section: Discussionmentioning

confidence: 83%

Section: Introductionmentioning

confidence: 99%

Randomized, Double-Blind Trial of the Effect of Fluid Composition on Electrolyte, Acid–Base, and Fluid Homeostasis in Patients Early After Subarachnoid Hemorrhage

et al. 2012

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“…BNP levels have also been reported to be elevated in patients with renal failure, left ventricular hypertrophy and myocardial disease as well as in subarachnoid hemorrhage. 22) Therefore, specificity to reflect impaired cardiac function either systolic or diastolic remains one of the limitations which makes it difficult to use BNP in the clinical situation. Interestingly, however, a number of these parameters associated with raised BNP levels (e.g.…”

Section: Discussionmentioning

confidence: 99%

Screening for Cardiac Dysfunction in Asymptomatic Patients by Measuring B-type Natriuretic Peptide Levels.

et al. 2000

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EART failure is one of the world's leading medical problems.1) Impairment of either left ventricular contraction (e.g. systolic) or compliance (e.g. diastolic) leads to the pathologic condition. 2,3)Heart failure is present in approximately 10 % of the elderly, 4) and patients with asymptomatic left SUMMARYEarly diagnosis and treatment of heart failure lead to improved survival; pre-clinical detection would thus be beneficial. A non-invasive biochemical testing method would indeed be ideal to screen for the condition. In the present study, we sought to determine whether circulating levels of B-type natriuretic peptide (BNP) correlate with cardiac function in asymptomatic subjects. 294 consenting asymptomatic subjects were examined. BNP levels in elevated patients (> 18.4 pg / ml) showed significant correlation with echocardiographic parameters of the systolic and diastolic functions (EF r = − 0.51, FS r = − 0.50, E / A r = 0.42, p < 0.01). Moderate correlation with the CTR on chest X-ray was also seen (r = 0.23, p < 0.01). Multiple regression analysis showed numerous echocardiographic and hemodynamic parameters including those of systolic and diastolic function in addition to left ventricular wall thickness, blood pressure and serum creatinine levels to be significantly associated with raised BNP levels. Elevated BNP levels reflect cardiac function (both systolic and diastolic) in the asymptomatic population. Detection of cardiac dysfunction by the non-invasive biochemical test may prove useful in early pre-clinical diagnosis of heart failure. (Jpn Heart J 2000; 41: 205-214)

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“…Two putative mechanisms are the interference of sympathetic input to the kidney and central elaboration of a circulating natriuretic factor [13,16].…”

Section: Discussionmentioning

confidence: 99%

Hyponatremia associated with demyelinating disease of the nervous system

et al. 2013

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A 63-year-old man was diagnosed with periodontitis and underwent tooth extraction. Several days later, he suffered a high fever, ischuria, a change in personality, and disorientation. A urologist examined him and found severe hyponatremia (117 mEq/L), and he was then transferred to our hospital. On admission, physical findings revealed dysfunction of the bladder and bowel, altered mental status, and hypovolemia. Blood chemistry showed serum sodium of 120 mEq/L, a serum urate of 1.4 mg/dL, urinary Na of 61 mEq/L, and fractional urate excretion of 16 %. Examination of the cerebrospinal fluid (CSF) showed monocytosis. Magnetic resonance imaging (MRI) of the brain and spinal cord showed multiple lesions characterized by hyperintensity on T2-weighted sequences, suggesting demyelinating disease. His sodium concentration normalized 3 days after volume replacement therapy, and his altered mental status along with the dysfunction of the bladder and bowel were promptly improved after the initiation of high-dose glucocorticoids. Additionally, the abnormal lesions on MRI markedly

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Secretion of brain natriuretic peptide in patients with aneurysmal subarachnoid haemorrhage

Cited by 337 publications

References 21 publications

Randomized, Double-Blind Trial of the Effect of Fluid Composition on Electrolyte, Acid–Base, and Fluid Homeostasis in Patients Early After Subarachnoid Hemorrhage

Randomized, Double-Blind Trial of the Effect of Fluid Composition on Electrolyte, Acid–Base, and Fluid Homeostasis in Patients Early After Subarachnoid Hemorrhage

Screening for Cardiac Dysfunction in Asymptomatic Patients by Measuring B-type Natriuretic Peptide Levels.

Hyponatremia associated with demyelinating disease of the nervous system

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