Secretion without Golgi

Prudovsky, Igor; Tarantini, Francesca; Landriscina, Matteo; Neivandt, David J.; Soldi, Raffaella; Kirov, Aleksandr; Small, Deena; Kathir, Karuppanan Muthusamy; Rajalingam, Dakshinamurthy; Kumar, Thallapuranam Krishnaswamy Suresh

doi:10.1002/jcb.21513

Cited by 117 publications

(147 citation statements)

References 167 publications

(266 reference statements)

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“…nonclassical secretory pathway [13][14][15][16]. Experimental studies suggested that FGF1 exhibited a physiologic profile that included a variety of metabolic responses.…”

Section: Methodsmentioning

confidence: 99%

Fibroblast growth factor 1 levels are elevated in newly diagnosed type 2 diabetes compared to normal glucose tolerance controls

Wang

Yang

et al. 2016

Endocr J

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“…nonclassical secretory pathway [13][14][15][16]. Experimental studies suggested that FGF1 exhibited a physiologic profile that included a variety of metabolic responses.…”

Section: Methodsmentioning

confidence: 99%

Fibroblast growth factor 1 levels are elevated in newly diagnosed type 2 diabetes compared to normal glucose tolerance controls

Wang

Yang

et al. 2016

Endocr J

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“…Nonclassical or leaderless secretion was first described 20 years ago for two mammalian proteins (Cooper and Barondes, 1990;Rubartelli et al, 1990) and since then considerable progress has been made in characterizing a number of different pathways (Fig. 2) in mammalian and yeast cells, which will not be described in detail here (for review, see Nombela et al, 2006;Nickel and Seedorf, 2008;Prudovsky et al, 2008;Nickel and Rabouille, 2009). It therefore seems likely that nonclassical secretion is common to all eukaryotes, including plants, although this field is essentially unexplored.…”

Section: How Do Proteins Reach the Plant Cell Wall?mentioning

confidence: 99%

Straying off the Highway: Trafficking of Secreted Plant Proteins and Complexity in the Plant Cell Wall Proteome

2010

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From simply skimming through the abstract lists of more or less any collection of both basic and applied plant-related journals, it is immediately apparent that the plant cell wall represents a nexus of many fields of research: growth and development, plant-pathogen interactions, abiotic stress, self-and interorganismal recognition, signaling systems, numerous primary and specialized metabolic processes, biomaterials and bioproducts, and many others. That said, and to deal with an issue of semantics, while the term cell wall can refer specifically to the structural matrix that surrounds all plant cells, for the purposes of this Update it is used more broadly, also to include the apoplast, or extracellular environment. Given its multifunctional nature then, it is not surprising that the apoplast houses a dynamic and complex proteome, and the compendium of cell wall proteins continues to grow as researchers from disparate disciplines discover new roles for extracellular proteins. In addition, however, as cell wall proteomics projects develop and the subcellular localizations of an ever-growing list of plant proteins are determined, a number of surprises have been thrown up, both in terms of the identity of secreted proteins and the trafficking pathways that they follow. The purpose of this Update is to give some examples of previously unsuspected aspects of plant cell wall protein trafficking that are challenging longheld assumptions, rather than to provide an exhaustive review, and to highlight some questions that can be categorized into the "who, how, where, and when" of the cell wall proteome.

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“…However, several extracellular proteins such as IL1␣, IL1␤, fibroblast growth factor (FGF1 and FGF2), S100A13, sphingosine kinase 1, gelectin-1, and the extra vesicular p40 fragment of Syt1 all lack N-terminal signal sequences and are exported via ER-Golgi independent non-classical routes (10,(12)(13)(14). Most of these proteins are involved in several key biological functions, such as angiogenesis, cell proliferation or differentiation, and tumor growth.…”

mentioning

confidence: 99%

The IL1α-S100A13 Heterotetrameric Complex Structure

Mohan

2011

Journal of Biological Chemistry

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Interleukin 1␣ (IL1␣) plays an important role in several key biological functions, such as angiogenesis, cell proliferation, and tumor growth in several types of cancer. IL1␣ is a potent cytokine that induces a wide spectrum of immunological and inflammatory activities. The biological effects of IL1␣ are mediated through the activation of transmembrane receptors (IL1Rs) and therefore require the release of the protein into the extracellular space. IL1␣ is exported through a non-classical release pathway involving the formation of a specific multiprotein complex, which includes IL1␣ and S100A13. Because IL1␣ plays an important role in cell proliferation and angiogenesis, inhibiting the formation of the IL1␣-S100A13 complex would be an effective strategy to inhibit a wide range of cancers. To understand the molecular events in the IL1␣ release pathway, we studied the structure of the IL1␣-S100A13 tetrameric complex, which is the key complex formed during the non-classical pathway of IL1␣ release.

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Secretion without Golgi

Cited by 117 publications

References 167 publications

Fibroblast growth factor 1 levels are elevated in newly diagnosed type 2 diabetes compared to normal glucose tolerance controls

Fibroblast growth factor 1 levels are elevated in newly diagnosed type 2 diabetes compared to normal glucose tolerance controls

Straying off the Highway: Trafficking of Secreted Plant Proteins and Complexity in the Plant Cell Wall Proteome

The IL1α-S100A13 Heterotetrameric Complex Structure

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