Secretory breast carcinoma with a papillary‐predominant pattern: an unusual morphological variant

Shui, Ruohong; Cheng, Ya-Min; Bai, Qianming; Yang, Wentao

doi:10.1111/his.13232

Cited by 18 publications

(18 citation statements)

References 30 publications

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“…Identification of a recurrent chromosomal rearrangement in secretory carcinoma, t(12;15)(p13;q25), resulting in a fusion between E26 transformation‐specific translocation variant 6 ( ETV6 ) and neurotrophic receptor tyrosine kinase 3 ( NTK3 ), allowed for a potentially targeted approach to management . This fusion has thus far been reported in 95.2% (40 of 42) of the cases tested in the literature …”

Section: Introductionmentioning

confidence: 99%

“…21 This fusion has thus far been reported in 95.2% (40 of 42) of the cases tested in the literature. 14,[21][22][23][24][25][26][27][28][29][30] Here, we sought to characterise the clinical, pathological and molecular features of this unusual, typically indolent subtype of breast cancer further, with a focus on particularly aggressive clinical courses through a review of cases diagnosed and managed in a single large tertiary cancer centre during a period of 25 years.…”

Section: Introductionmentioning

confidence: 99%

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Secretory carcinoma of the breast: clinicopathologic profile of 14 cases emphasising distant metastatic potential

et al. 2019

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Aims Secretory carcinoma of the breast (SCB) is a rare histological type of breast carcinoma with a generally indolent clinical behaviour. We aim to elucidate the clinical, pathological and molecular findings of SCB cases and identify characteristics associated with aggressive clinical courses. Methods and results Fourteen patients with SCB were identified, including 12 women and two men, with a median age of 56 years (range = 8–81 years). Clinical data, histological diagnosis, molecular findings and follow‐up were reviewed. Eight patients presented with palpable masses and four patients with radiographic abnormalities. All cases were unilateral. Surgical procedures included excisional biopsies and ipsilateral mastectomies. In 10 cases, oestrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2) results were obtained, with six cases positive for ER and three positive for PR. All cases lacked HER2 overexpression. Sentinel lymph node biopsy was performed in 10 cases, and two patients had axillary lymph node metastasis. Follow‐up ranged from 21 to 212 months (median = 70 months). Two patients developed distant metastasis of SCB. Molecular analysis of these aggressive tumours revealed amplification of the 16p13.3 locus, a TERT promotor mutation and loss of 9p21.3 locus. Review of the literature for SCB cases with distant metastasis was performed. Conclusions Although SCBs are generally associated with a favourable prognosis, our study and review demonstrate that a subset of SCBs may develop distant metastases. Further studies are warranted to identify markers predictive of more aggressive clinical behaviour in this rare breast cancer subtype.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Secretory carcinoma of the breast: clinicopathologic profile of 14 cases emphasising distant metastatic potential

et al. 2019

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“…Ozguroglu et al (28) reviewed 121 cases of SBC, of which 61 underwent surgery, including 20 cases of modi ed radical mastectomy, 12 cases of radical mastectomy, 17 cases of mastectomy and 12 cases of wide local excision, and demonstrated that the results of wide local excision did not differ signi cantly from those of other surgical procedures. Shui et al (29) suggested that, if the size of the primary tumor is < 2 cm, axillary metastasis is uncommon. Li et al (21) believed that breast-conserving surgery and SLNB can only be performed on those patients whose primary tumors are sized < 2 cm and have no axillary LMN.…”

Section: Discussionmentioning

confidence: 99%

Bilateral Primary Breast Cancer: A Case Report and Literature Review

Fan

Liang

et al. 2020

Preprint

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BackgroundInvasive micropapillary carcinoma (IMPC) and secretory carcinoma of the breast (SCB) are relatively rare types of breast cancer. IMPC is usually associated with high incidence of lymphovascular invasion, lymph node metastasis and poor prognosis. While SCB usually carries a relatively favorable prognosis, cases of axillary and distant metastases have been reported. Clinicians generally adopt systemic treatments based on the histopathological findings of the patients to improve the prognosis, but there is currently no consensus on the optimal treatment for these two types of cancer.Case presentationWe treated a 50‐year‐old woman with lung cancer history who presented with a single lump in each breast. Following bilateral breast-conserving surgery, the diagnosis of SCB of the left breast and IMPC of the right breast was confirmed with immunohistochemistry. It is worth noting that the pathological results of left lung adenocarcinoma centered on micropapillary-type was same as the invasive micropapillary component of right breast.ConclusionsWe reported this case of bilateral primary relatively-rare-form breast cancer for its extremely rare occurrence and there are less than 20 cases of SCB reported worldwide till now. It is also significative to distinguish this primary tumor of right breast from metastatic cancer. Our histopathologic diagnosis and synthetical therapy scheme will provide material for SCB and IMPC. To facilitate the diagnosis and prognosis of such relatively rare tumors, more cases will need to be reported.

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“…Pathologically, SBC is typically triple negative but low-grade, and the copious amount of intra/extracellular secretions make the tumors strongly S-100 reactive [5]. Secretory breast carcinoma has also recently been noted to belong to the basal-like spectrum of breast carcinomas.…”

Section: Discussionmentioning

confidence: 99%

“…It is most often receptor triple negative (ER, PR, and HER2 negative) but low grade. Histologically, SBC presents as a solid, tubular, microcystic and rarely papillary pattern [5]. Due to the presence of secretory ma-my with axillary lymph node dissection.…”

Section: Introductionmentioning

confidence: 99%

Secretory Carcinoma of the Breast: An Elusive Presentation of This Rare Pathology

Joseph¹,

Morgani²,

Heimann³

et al. 2017

Int J Oncol Res

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terial, samples are strongly S-100 protein reactive. Secretory breast carcinoma is driven by the fusion gene ETV6-NTRK3 that results from a balanced translocation t (12; 15) [6].Fortunately for most diagnosed with SBC, the course is indolent even in the setting of nodal metastasis, which is present in 15-35% cases at presentation [2,3,7]. Although distant metastasis is very rare, local recurrence is described, recurring as far as 16 years after treatment [8]. At present the primary treatment remains surgical. Case ReportA 75-year-old female presented to our clinic with complaint of new onset right nipple pain and swelling for 4 weeks. Family history was significant for breast cancer in a maternal and a paternal first cousin, as well as a maternal aunt who succumbed to her disease at age 50. The initial physical exam revealed a tender, erythematous, enlarged right nipple, but no palpable masses. The initial impression was mastitis, and she was started on azithromycin. A diagnostic mammogram showed asymmetry of the right nipple compared to the left ( Figure 1), however, ultrasound at that time was unremarkable. Her symptoms did not improve with antibiotics.A repeat targeted ultrasound of this area revealed an abnormal right nipple complex (Figure 2). She was then assessed by a breast surgeon, and the exam at that time revealed a firm, tender, erythematous mass of the superior aspect of the right nipple, and a palpable right axillary lymph node. Ultrasound-guided fine needle aspiration biopsy of the axillary node was consistent with metastatic adenocarcinoma. The tumor stained positive AbstractSince first being noted in the literature in 1966, Secretory Breast Carcinoma (SBC) continues to be better defined in terms of its clinical, histologic, and genetic features. However, its unique presentation can elude seasoned practitioners from making a clinical diagnosis. Furthermore, there is neither consensus nor guidelines as to the optimal treatment approach for SBC. We are presenting this case report and literature review to raise awareness about SBC by demonstrating how uniquely this pathology can present itself, to summarize the current literature, and to present our specific approach to this rare cancer.

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Secretory breast carcinoma with a papillary‐predominant pattern: an unusual morphological variant

Cited by 18 publications

References 30 publications

Secretory carcinoma of the breast: clinicopathologic profile of 14 cases emphasising distant metastatic potential

Secretory carcinoma of the breast: clinicopathologic profile of 14 cases emphasising distant metastatic potential

Bilateral Primary Breast Cancer: A Case Report and Literature Review

Secretory Carcinoma of the Breast: An Elusive Presentation of This Rare Pathology

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