Int J Oncol Res 2017
DOI: 10.23937/ijor-2017/1710002
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Secretory Carcinoma of the Breast: An Elusive Presentation of This Rare Pathology

Abstract: terial, samples are strongly S-100 protein reactive. Secretory breast carcinoma is driven by the fusion gene ETV6-NTRK3 that results from a balanced translocation t (12; 15) [6].Fortunately for most diagnosed with SBC, the course is indolent even in the setting of nodal metastasis, which is present in 15-35% cases at presentation [2,3,7]. Although distant metastasis is very rare, local recurrence is described, recurring as far as 16 years after treatment [8]. At present the primary treatment remains surgical. … Show more

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“…The TNBC has an increased likelihood of distant recurrence and death, with the risk of recurrence peaking at 3 years and the median survival of 13.3–18 months in the metastatic setting 10–12. By comparison, the 5-year survival rate for SBC is 87.2–93.2%, with a greater likelihood of survival in its juvenile form 13 14…”
Section: Introductionmentioning
confidence: 99%
“…The TNBC has an increased likelihood of distant recurrence and death, with the risk of recurrence peaking at 3 years and the median survival of 13.3–18 months in the metastatic setting 10–12. By comparison, the 5-year survival rate for SBC is 87.2–93.2%, with a greater likelihood of survival in its juvenile form 13 14…”
Section: Introductionmentioning
confidence: 99%