Secretory Carcinoma of the Breast

Özgüroǧlu, Mustafa; Tascilar, Koray; İlvan, Şennur; Soybir, Gürsel; Çelik, Varol

doi:10.1159/000086782

Cited by 31 publications

(8 citation statements)

References 62 publications

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“…Tavassoli et al 4,5 reported that secretory carcinoma has been found in patients aged from 3 to 87 years of age (median 25 years). Ozguroglu et al 6 reported that most (approx. 70%) of the patients were over 20 years old and described the entity as a disease affecting adults.…”

Section: Discussionmentioning

confidence: 99%

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A rare case of extensive ductal carcinoma in situ of the breast with secretory features

et al. 2012

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We report a very rare case of extensive ductal carcinoma in situ (DCIS) of the breast with secretory features in a 30-year old Japanese woman. The patient presented with a nodule in the lower inner quadrant of the left breast measuring approximately 2–3 cm, accompanied by an irregular tumor shadow with segmental microcalcification on mammography. These findings suggested malignancy, and excisional biopsy was performed following core needle biopsy. Pathological diagnosis was that of DCIS with secretory features. A treatment plan of simple mastectomy and sentinel lymph node biopsy was chosen. Most previous reports have only described invasive secretory carcinoma of the breast. We have only been able to find 2 case reports of non-invasive secretory lesion in the English literature to date. Because the characteristics of this lesion are not widely known, we thought it important to share our findings.

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Section: Discussionmentioning

confidence: 99%

“…4,7,8 Atypia is mild or moderate and mitotic activity is usually low. 3,6,7 A typical finding is the presence of secretory material both in the cytoplasm and in the glandular spaces formed by these cells. 7 These tumor cells contain PAS or α-lactalbumin-positive secretory material.…”

Section: Discussionmentioning

confidence: 99%

A rare case of extensive ductal carcinoma in situ of the breast with secretory features

et al. 2012

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“…Furthermore, due to the scarcity of reported cases, the significance of neoadjuvant chemotherapy, adjuvant chemotherapy, and postoperative radiotherapy remains unclear. Breast conservative surgery, modified radical mastectomy, and radical mastectomy are the most frequent procedures in adults, whereas simple mastectomy, local excision with sentinel lymph node biopsy, and complete axillary dissection are potentially adequate in children 26 . These were the surgical methods performed in our study patients.…”

Section: Discussionmentioning

confidence: 99%

Clinicopathologic and molecular characteristics of 44 patients with pure secretory breast carcinoma

Li¹,

Wu²,

Li³

et al. 2019

Cancer Biology & Medicine

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Objective Secretory breast carcinoma (SBC) is a rare type of breast malignancy, accounting for less than 0.02% of all infiltrating breast malignancies. The pure SBC, a type of SBC without another type of breast malignant neoplasm, is particularly rare. This study aimed to investigate the clinicopathologic and molecular features of pure SBC. Methods The main pathological parameters such as estrogen receptor (ER), progesterone receptor (PR), and human epithelial growth factor receptor 2 (C-erbB-2) were detected by immunohistochemistry (IHC), and the clinicopathologic and prognostic difference were compared with invasive ductal carcinoma (IDC). Fluorescent in situ hybridization (FISH) and reverse transcription polymerase chain reaction (RT-PCR) was performed to identify the ETV6-NTRK3 rearrangement of SBC. Results We found that the positivity rates of ER, PR, C-erbB-2, p53, and S-100 were 47.7% (21/44), 52.3% (23/44), 36.4% (16/44), 27.3% (12/44), and 95.5% (42/44), respectively, which were higher than those reported in previous studies. Special periodic acid-Schiff analysis was performed in 36 patients, and the value of the Ki-67 index ranged from 1% to 50% (mean value: 10%). Interestingly, most patients with pure SBC harbored an ETV6-NTRK3 rearrangement with an 88.6% (39/44) expression rate. Compared with IDC, the tumor size of most patients with SBC was larger than 2 cm ( P = 0.024). Ultrasound showed benign lesions, and the total misdiagnosis rate was higher ( P = 0.020). Although the pathological classification was mostly triple-negative breast cancers ( P = 0.036), there was less metastasis ( P = 0.029), and the overall prognosis was better than that of the IDC group. Conclusions Although axillary lymph node metastasis, local recurrence, or distant metastasis may occur, SBC is also considered an indolent neoplasm with a good prognosis. Once diagnosed, surgical treatment should be performed as soon as possible, followed by appropriate adjuvant chemotherapy, irradiation, and endocrine therapies.

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“…It is interesting that a papillary‐cystic growth pattern is characteristic in MASC, but a papillary‐predominant architecture has seldom been reported in breast SC. We have reviewed the previous studies of SC from 1980 to 2015; SC with a focal papillary pattern or an intraductal papillary component was described in a few studies (Table ) . Only two cases of SC with a predominantly papillary growth pattern were reported, and the significance of this uncommon morphological feature was not discussed further.…”

Section: Discussionmentioning

confidence: 99%

Secretory breast carcinoma with a papillary‐predominant pattern: an unusual morphological variant

et al. 2017

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Secretory Carcinoma of the Breast

Cited by 31 publications

References 62 publications

A rare case of extensive ductal carcinoma in situ of the breast with secretory features

A rare case of extensive ductal carcinoma in situ of the breast with secretory features

Clinicopathologic and molecular characteristics of 44 patients with pure secretory breast carcinoma

Secretory breast carcinoma with a papillary‐predominant pattern: an unusual morphological variant

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