1979
DOI: 10.1084/jem.150.6.1577
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Secretory component as the receptor for polymeric IgA on rat hepatocytes.

Abstract: The rapid and active transport of polymeric IgA from the blood to the bile (1, 2) is selective (3, 4), which suggests the existence of a specific receptor for this molecule. The liver cells responsible for the transfer have been identified as the hepatocytes by autoradiography and electron microscopy of the livers of rats killed 5, 30, and 60 min after the injection of radiolabeled IgA (5). 5 rain after being injected, the radiolabeled IgA appeared to be bound to the sinusoidal membrane of the hepatocytes. We … Show more

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Cited by 128 publications
(42 citation statements)
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“…The role of the secretory component on rat hepatocytes in hepato-biliary transport of polymeric IgA is well established in rats (23)(24)(25). Three lines of evidence ruled out the participation of secretory component as a receptor for large-latticed lgA-IC in our studies.…”
Section: Discussionmentioning
confidence: 99%
“…The role of the secretory component on rat hepatocytes in hepato-biliary transport of polymeric IgA is well established in rats (23)(24)(25). Three lines of evidence ruled out the participation of secretory component as a receptor for large-latticed lgA-IC in our studies.…”
Section: Discussionmentioning
confidence: 99%
“…However, guinea pigs and dogs which share with humans a poor plgA clearance through the liver, have high concentrations of plgA in the thoracic duct lymph, like rats or mice [37], The location of the poly-Ig-R in hepatobiliary tissues remains the most strik ing difference between species with high and low hepatic clearance of IgA, respectively. Synthesis and plasma membrane location of the poly-Ig-R/SC has been unequivocally as signed to hepatocytes in rats, rabbits and mice [38], and the SC-mediated transfer of plgA through hepatocytes is analogous to that described in enterocytes [39], However, only biliary ductular cells have been shown to synthesize the poly-Ig-R in humans, dogs and guinea pigs [6,29,39]. We confirmed recently, using electron microscopy with immunostaining, that at the very beginning of intrahepatic bile ducts, the so-called 'Her ring duct', only the biliary side of the duct, lined with cholangiocytes, expressed SC: no imrnunostaining of SC could be obtained at the hepatic side of the duct, lined with hepa tocytes [Seilles et al, unpubl.…”
Section: Structure and Biology Of Igamentioning
confidence: 99%
“…Immunologists comparing the different types of immunoglobulins found in various secretions (e.g., serum, milk, saliva, and the intestinal lumen) speculated that the form of IgA found in external secretions (called secretory IgA, due to the presence of an additional protein component) was selectively transported across the epithelial cell barrier (577,578). The pathway and origin of the component acquired during transport were actively investigated, and in 1980 secretory component (SC) in secretory IgA was identified as the ectoplasmic domain of the intestinal epithelial cell membrane receptor that binds dimeric IgA and transports it through multiple intracellular compartments to the opposite side of the cell (391,423). These two historic transcytotic systems are still actively investigated today.…”
Section: Introductionmentioning
confidence: 99%