Secretory IgA(S-IgA) levels in sera from patients with diffuse panbronchiolitis.

Noda, Yoichi; Yasuoka, Susumu; Tani, Kenji; Ogura, Takeshi; Ogawara, Mitumasa; Kitatani, Fumihiko

doi:10.2169/internalmedicine1962.28.189

Cited by 5 publications

(1 citation statement)

References 15 publications

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“…S-IgA is secreted locally from the airway walls onto the mucous membrane and is believed to play an important role in protecting the mucous membrane from infection (3,4). Previously we have reported that the levels of serum IgA and S IgA, particularly the latter, are elevated in patients with diffuse panbronchiolitis and severe brochiectasis (5). However, the mechanism of response of the local and systemic IgA systems to persistent respiratory infection with Pseudomonas aeruginosa is non known in these disease.…”

Section: Introductionmentioning

confidence: 99%

Analysis of IgA Antibody to Pseudomonas aeruginosa in Sera and Sputa of Patients with Chronic Airway Diseases.

et al. 1992

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The change of IgA system for Pseudomonas infection was examined by enzyme-linked immunosorbent assay of the system in sera and sputa of patients with chronic airway diseases. The anti-Pseudomonas total IgA antibody titers in both sera and sputa were not elevated in group I with no infection (mainly chronic bronchitis) and group II infected with bacteria other than Pseudomonas, but were elevated in group III colonized transiently with Pseudomonas [diffuse panbronchiolitis (DPB) and bronchiectasis] and group IV colonized persistently with Pseudomonas (mainly DPB). The elevation in the sera and sputa were mainly due to monomeric IgA and polymeric IgA (S-IgA), respectively, and values were significantly higher in group III than in group IV only in the sera. These results indicate that the IgA system is enhanced in advanced DPB and bronchiectasis complicated by Pseudomonas infection, and that the antiPseudomonas IgA antibody titer in serum is more useful than that in sputum for the diagnosis of respiratory Pseudomonas infection. (Internal Medicine 31: 575-582, 1992)

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Section: Introductionmentioning

confidence: 99%

Analysis of IgA Antibody to Pseudomonas aeruginosa in Sera and Sputa of Patients with Chronic Airway Diseases.

et al. 1992

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Epidemiology of the M-component immunoglobulin types of multiple myeloma

Herrinton¹,

Demers²,

Weiss³

et al. 1993

Cancer Causes Control

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The purpose of this population-based case-control study was to learn whether risk factors differ for the individual immunoglobulin types of multiple myeloma. In particular, we sought to determine whether IgA and IgG myeloma were related to a history of exposure to reported IgA- and IgG-stimulating conditions, respectively, or to a history of selected occupational and physicochemical exposures. The M-component immunoglobulin type was determined from immunoelectrophoresis as reported in medical records, and exposure status was obtained through in-person interviews. IgG (56 percent) and IgA (22 percent) M-components predominated. For 17 percent of cases, no peak was found on immunoelectrophoresis; they were presumed to have light-chain myeloma. Persons with these three types of myeloma did not differ with respect to distributions of age or race, but a somewhat higher proportion of light-chain cases were women (58 percent cf 45 percent of all other cases). Detailed analysis of the IgA and IgG subtypes provided little evidence that they differ with respect to prior immune stimulation or employment in several specific jobs. IgA myeloma, but not IgG myeloma, was associated modestly with a history of exposure to chest and dental X-rays. Our study provides little evidence that IgA and IgG myeloma differ with respect to the risk factors examined.

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Chronic transmural bronchiolitis: a non-specific lesion of small airways.

1992

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Aims: To investigate nine patients with histological changes at open lung biopsy compatible with so-called "small airways disease"; to define these changes and distinguish them from other types of bronchiolitis; and to correlate them with clinical features, respiratory physiology, and other laboratory investigations.Methods: The open biopsy sections and the clinical records were reviewed. Results: There was chronic inflammation of the walls of centri-acinar respiratory bronchioles and peribronchiolar alveoli.

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Secretory IgA(S-IgA) levels in sera from patients with diffuse panbronchiolitis.

Cited by 5 publications

References 15 publications

Analysis of IgA Antibody to Pseudomonas aeruginosa in Sera and Sputa of Patients with Chronic Airway Diseases.

Analysis of IgA Antibody to Pseudomonas aeruginosa in Sera and Sputa of Patients with Chronic Airway Diseases.

Epidemiology of the M-component immunoglobulin types of multiple myeloma

Chronic transmural bronchiolitis: a non-specific lesion of small airways.

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