Sector (Partial) Oculo(dermal) Melanocytosis in 89 Eyes

Association of Ocular and Oculodermal Melanocytosis With the Rate of Uveal Melanoma Metastasis

“…In summary, oculo(dermal) melanocytosis is an important predisposing factor for uveal melanoma. 3,4 Uveal melanoma carries prominent risk for metastasis in 25% by 10 years, with each millimeter increase in thickness promoting increasing metastatic rate. 22 Recognition of congenital melanocytosis early in life and understanding of the possible magnitude of monitoring these patients are emphasized.…”

“…The main concern with oculo(dermal) melanocytosis is the risk for development of melanoma, predominantly in the uvea. [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21] Oculo(dermal) melanocytosis is rare in the general population. Cowan and Balistocky 6 reviewed 25 000…”

Submillimeter Choroidal Melanoma Detection by Enhanced Depth Imaging Optical Coherence Tomography in a Patient With Oculodermal Melanocytosis

“…10 Melanocytosis can occur as a diffuse pigmentary condition involving the entire uvea or it can be localized to a sector of tissue. [5][6][7][8]10 Diffuse melanocytosis in whites carries an estimated lifetime risk for development of melanoma at 1 in 400 cases. 11 In reverse, only 3% of eyes with uveal melanoma demonstrate melanocytosis, and it was determined that the 10-year rate of metastasis was 48% compared with 24% in eyes with melanoma lacking melanocytosis.…”

“…[1][2][3][4] Oculodermal melanocytosis is a benign congenital condition with increased melanocytes in the skin, episclera, uvea, orbit, meninges, palate, and eardrum. [5][6][7] This condition occurs in less than 1% of the general population but carries a 35-fold risk for development of uveal melanoma. 5,8 Our team has shown in a retrospective analysis of 7,872 eyes with melanoma that those arising from melanocytosis display double the risk for metastasis compared with those without melanocytosis, and this was further confirmed in a case-matched cohort study, when controlling for other factors.…”

Freie Vorträge

“…Die molekularen Effekte von kaltem atmosphärischem Plasma auf das maligne Melanom T. Zimmermann 1 , C. Schneider 1 , L. Gebhardt 2 , S. Arndt 3 , S. Karrer 3 , J. L. Zimmermann 4 , M. J. M. Fischer 5 , A. K. Bosserhoff 1 1 Friedrich-Alexander Universität Erlangen-Nürnberg, Institut für Biochemie, Erlangen, Deutschland 2 Friedrich-Alexander Universität Erlangen-Nürnberg, Institut für Physiologie und Pathophysiologie, Erlangen, Deutschland 3 Universitätsklinikum Regensburg, Klinik und Poliklinik für Dermatologie, Regensburg, Deutschland 4 Terraplasma medical GmbH, Garching, Deutschland 5 Medizinische Universität Wien, Institut für Physiologie, Wien, Deutschland Kaltes atmosphärisches Plasma (KAP) bezeichnet ein Gemisch aus reaktiven Sauerstoff-und Stickstoffspezies (ROS/RNS), geladenen Partikeln und UV-Licht, welches durch partielle Ionisierung der Umgebungsluft entsteht. Neben bereits zugelassenen Anwendungen in der Medizintechnik, Hygiene und Wasseraufbereitung gewinnt eine potenzielle Applikation in der Tumortherapie zunehmend an Bedeutung.…”