Secular trends of age at menarche and the effect of famine exposure on age at menarche in rural Chinese women

Wu, Xinyuan; Bao, Lei; Du, Zhen; Liu, Xiaotian; Liao, Wei; Kang, Ning; Sun, Chunyang; Abdulai, Tanko; Zhai, Zhihan; Wang, Chongjian; Li, Yuqian

doi:10.1080/03014460.2022.2041092

Cited by 4 publications

(3 citation statements)

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“…The variation of puberty can be demonstrated by the girl's age at puberty. Figure 2 demonstrates the variation in the ages of puberty among regions, countries, and the same population (Eckert-Lind et al, 2020;Leone and Brown, 2020;Wu et al, Frontiers in Pharmacology frontiersin.org 2022). The variation exists among not only racial groups but also the regions and countries (Figures 2A-D).…”

Section: Trends and Variation Of Puberty Among Different Regionsmentioning

confidence: 99%

“…Living conditions and environmental factors contribute to the body’s growth; in particular, food supplies and nutrients may have led to such a variation. It has been reported that both fetal and childhood famine exposure, especially in late childhood, were positively associated with increased age at menarche ( Wu et al, 2022 ).…”

Section: Policy Options and Implications-life Stages And Age Differ S...mentioning

confidence: 99%

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Bring the life stages into the domain of basic and clinical pharmacology

et al. 2022

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Completely distinct physiological conditions and immune responses exist among different human life stages. Age is not always consistent with the life stage. We proposed to incorporate the concept of the life stages into basic and clinical pharmacology, including clinical trials, drug labels, and drug usage in clinical practice. Life-stage-based medical treatment is the application of medicine according to life stages such as prepuberty, reproductive, and aging. A large number of diseases are life-stage-dependent. Many medications and therapy have shown various age effects but not been recognized as life-stage-dependent. The same dosage and drug applications used in different life stages lead to divergent outcomes. Incorporating life stages in medicine and drug usage will enhance the efficacy and precision of the medication in disease treatment.

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Section: Trends and Variation Of Puberty Among Different Regionsmentioning

confidence: 99%

Section: Policy Options and Implications-life Stages And Age Differ S...mentioning

confidence: 99%

Bring the life stages into the domain of basic and clinical pharmacology

et al. 2022

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“…Our preliminary study found that the average age at menarche declined from 16.98 years for those born in 1935 to 13.87 years for those born in 2000, a decline of 0.077 years per one-year and 0.729 years per decade. Age at menarche showed a decreasing trend in rural China [7]. The age at menarche is associated with women's health and is determined by the interplay of environmental, genetic factors, and lifestyle [8].…”

Section: Introductionmentioning

confidence: 99%

Age at Menarche, Menopause Status and Metabolic Syndrome and its Components: Findings from the Henan Rural Cohort Study

Wu,

Zhen,

Liu

et al. 2023

Exp Clin Endocrinol Diabetes

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Introduction To evaluate the effect of age at menarche on metabolic syndrome (Mets) and its components and explore the impact of menopause status on the association between age at menarche and Mets in rural Chinese women. Methods This cross-sectional study enrolled 23382 women from the Henan Rural Cohort study. The relationship between age at menarche and Mets was assessed using logistic regression and restricted cubic spline. Interaction plots were used to describe interactive eﬀects of age at menarche and menopause status on Mets. Results Age at menarche was inversely associated with the risk of Mets with the adjusted OR of 1.16, 0.98, 1.00, 0.82, and 0.77, respectively, for those with age at menarche≤13, 14, 15–16 (reference), 17, and≥18 years. Each year of delay in menarche age correlated with a 6.2% (P<0.001) lower risk of Mets. Among the components of Mets, an inverse association was observed between age at menarche and central obesity (OR (95% CI): 0.92 (0.90, 0.94)), abnormal FPG (OR (95% CI): 0.96 (0.94, 0.97)), abnormal BP (OR (95% CI): 0.967 (0.95, 0.98)), abnormal TG (OR (95% CI): 0.96 (0.94, 0.97)), and abnormal HDL-C (OR (95% CI): 0.96 (0.95, 0.98)). Significant interactions were discovered between age at menarche, menopause status, and the risk of Mets, central obesity, abnormal FPG, abnormal BP, and abnormal TG (all P interaction<0.001). The adverse effect of menopausal status on Mets, central obesity, abnormal FPG, abnormal BP, and abnormal TG decreased with delayed age at menarche. Conclusions Later menarche was associated with a lower risk of Mets. More importantly, the deleterious effect of menopause status on Mets decreased with the increase in age at menarche.

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Reliability of retrospective assessment of the age of first menstruation

Żarów,

Woronkowicz,

Spring

et al. 2023

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The age of the first menstruation is one of the indicators for assessing the course of puberty. It is also a sensitive indicator of the economic situation of individual professional groups or societies, and the low average age of menarche is widely recognized as a marker of society’s well-being. The aim of the study was to analyse the reliability of the retrospective method of assessing the age at menarche by comparing the results to the age obtained from continuous research. Data regarding the age at menarche came from longitudinal somatic development and physical fitness studies conducted between 1976 and 2022. In 2022, 47 women were examined. In continuous studies, the prospective method was used in the assessment of the age of first menstruation while in the 2004 and 2022 studies a retrospective method was applied. Only in 4 out of 47 women the age of the first menstruation declared in 2004 and 2022 (the women were 32–34 and 50–52 years old, respectively) was consistent with the one found in continuous studies. In other cases, there was a discrepancy between the age found in continuous studies and self-reported in 2004 or 2022 or between the age stated in 2004 and 2022. Of those women who were present for the 2022 study, 36 had information about the age of first menstruation from continuous studies and the age of menarche in 2004 was given. For this sample the arithmetic mean and the standard deviation of the age at menarche were calculated. It was found that the retrospective method often used in the assessment of the age of the first menstruation is not fully reliable, as the average discrepancy in the assessment ranged from nearly 1 month (0.05 years) to over 2 months (0.19 years) compared to the prospective method. Women surveyed in 2004 determined the age of the first menstruation more accurately compared to statements obtained 18 years later from the same women. This study suggests that long-term memory (LTM) of a significant life event of every woman is unreliable, as indicated by the difference in the declared age of the first menstruation of women examined in 2004 and 2022, which, in individual cases, was up to 3, 4 or 5 years.

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Secular trends of age at menarche and the effect of famine exposure on age at menarche in rural Chinese women

Cited by 4 publications

References 42 publications

Bring the life stages into the domain of basic and clinical pharmacology

Bring the life stages into the domain of basic and clinical pharmacology

Age at Menarche, Menopause Status and Metabolic Syndrome and its Components: Findings from the Henan Rural Cohort Study

Reliability of retrospective assessment of the age of first menstruation

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