Sécurité transfusionnelle et drépanocytose à Bamako, Mali – séroprévalence des infections à VIH, VHB, VHC et allo-immunisation anti-Rh et Kell chez les drépanocytaires

Diarra, Amadou; Kouriba, Bourèma; Guindo, Aldiouma; Dorie, A.; Diabaté, D T; Diallo, D.; Gulbis, Béatrice

doi:10.1016/j.tracli.2013.03.067

Cited by 2 publications

(5 citation statements)

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“…On the other hand, this prevalence in our patients is higher than that found by Baglo et al in a study of multiple transfusion recipients in Cotonou, Benin, where they reported a prevalence of 13.73% [12]. In addition, Diarra in Mali in 2011 and Kolou in Côte d'Ivoire in 2005 reported much lower prevalences of 4.4% [13] and 4% [14] respectively. Similarly, Pahuja et al in 2010 in India reported in a study in thalassemia patients a prevalence of 3.79% [15] and Yétéma et al in 2022 in Bobo Dioulasso in Burkina Faso reported in a study on multiple transfusion recipients a prevalence of 5.67% [16].…”

Section: Discussioncontrasting

confidence: 69%

Evaluation of the prevalence of anti-erythrocyte alloimmunization in 100 polytransfused patients in Lomé, Togo

S Hounogbé,

Magnang,

L Nadjir

et al. 2023

Int J Blood Transfus Immunohematol

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Aims: Red blood cells transfusion exposes recipients to a risk of immunization. The phenotyping of red blood cells and the search for irregular erythrocyte antibodies ensure immuno-hematological safety of the transfused patients. In Togo, these tests are not systematic in transfusion. The aim of the study was to determine the rate of immunization against erythrocyte antigens in polytransfused patients in Lomé. Methods: The search for irregular agglutinins was carried out by the indirect antiglobulin test in gel-filtration in 100 polytransfused patients selected at National Center for Research and Care of Sickle Cells disease and in the care units of Campus Teaching Hospital of Lomé in Togo, from October 1, 2021 to April 30, 2022. Results: The prevalence of alloimmunization was 27% with a total of 13 different alloantibodies identified. The most represented were anti-K (18.52%), anti-E (14.81%), anti-C (11.11%), anti-Jka (11.11%), and anti-M (11.11%). Alloantibodies were more frequent in A+ blood group patients and those who received more than 4 bags of packed red blood cells. There was no link between age, sex, and the pathologies involved on one hand, and the occurrence of anti-erythrocyte alloimmunization on the other. Conclusion: The rate of immunization against erythrocyte antigens is very high in polytransfused patients in Lomé. Systematic implementation of red blood cells phenotyping and irregular erythrocyte antibodies research before and after transfusion should ensure better immunological transfusion safety in Togo.

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Section: Discussioncontrasting

confidence: 69%

Evaluation of the prevalence of anti-erythrocyte alloimmunization in 100 polytransfused patients in Lomé, Togo

S Hounogbé,

Magnang,

L Nadjir

et al. 2023

Int J Blood Transfus Immunohematol

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“…Due to methodological flaws of one study [39], 15 studies were included in the review, thirteen were in the English and two in the French language ( Figure 1) [40][41][42][43][44][45][46][47][48][49][50][51][52][53][54].…”

Section: Search Resultsmentioning

confidence: 99%

“…Visually, the funnel plot looked symmetric ( Figure 3) [43] studied only children and Ugwu [53] only adults. Nine studies used the column gel technique [40,42,[46][47][48][49][50][52][53] for antibody testing, three, the tube technique (TT) [43,45,54], one used both TT and CGA [51] and two studies did not report the antibody testing technique [41,44]. All screening and identification reagents were procured from international sources except for the studies performed by Sekongo [47] and Kaliyu [51], which utilized screening and/or identification cells produced at their centre.…”

Section: Publication Biasmentioning

confidence: 99%

“…Generally, reports on the transfusion history of study participants were scanty; indication for transfusion, type of blood products (whole blood or RBC concentrates) and source of blood for transfusion (from related or non-related donors) were seldom reported. Some studies did not report mean (with standard deviation) or median (with range) number of transfused units [41,44,50,53]. For the 11 studies that reported these variables, the number of RBC units transfused per patient per study was generally low (mean 2.4 to 9.0 units, median 2-10, and ranged from 1-100).…”

Section: Transfusion Historymentioning

confidence: 99%

“…Eight studies included only individuals with the SS genotype[40,41,[43][44][45][46]53], five had a mixture of the SCD genotypes (i.e. SS, SC, Sthal)[47][48][49][50]54] and the remaining two[42,52] did not report on…”

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confidence: 99%

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Red Blood Cell Alloimmunization in Transfused Patients With Sickle Cell Disease in Sub-Saharan Africa; a Systematic Review and Meta-Analysis

Antwi-Boateng

Ngoma

Bates

et al. 2019

Transfusion Medicine Reviews

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Sickle cell disease (SCD) is the most common monogenic disorder in sub-Saharan Africa (SSA). Blood transfusion to increase the oxygen carrying capacity of blood is vital in the management of many patients with SCD. However, red blood cell (RBC) alloimmunization is a major challenge to transfusions in these patients. Commonly in SSA, pre-transfusion tests only involve ABO D grouping and compatibility without RBC antibody testing. Data on the frequency of RBC alloimmunization in patients with SCD in SSA is limited. We performed a systematic review and meta-analysis on available data on alloimmunization in transfused patients with SCD to determine the published prevalence of RBC alloimmunization in SCD patients in SSA. Six databases were systematically searched to identify relevant studies, without year or language restrictions. In all, 249 articles were identified and 15 met our selection criteria. The overall proportion of alloimmunization was 7.4 (95% CI: 5.1-10.0), per 100 transfused patients. Antibodies against E, D, C and K antigens accounted for almost half of antibody specificities and antibodies to low and high frequency antigens were also common and represented almost 30% (20% to low frequency antigens and 9% to high frequency antigens) of specificities. Heterogeneity between studies was moderate and meta-analysis found region of Africa as the major contributor to the heterogeneity. We also observed inconsistencies across studies in reporting of factors that may influence alloimmunization. This review provides an overview of the extent of the alloimmunization problem in SSA and provides a baseline against which to compare the effect of any interventions to reduce the alloimmunization risk.

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Sécurité transfusionnelle et drépanocytose à Bamako, Mali – séroprévalence des infections à VIH, VHB, VHC et allo-immunisation anti-Rh et Kell chez les drépanocytaires

Cited by 2 publications

References 0 publications

Evaluation of the prevalence of anti-erythrocyte alloimmunization in 100 polytransfused patients in Lomé, Togo

Evaluation of the prevalence of anti-erythrocyte alloimmunization in 100 polytransfused patients in Lomé, Togo

Red Blood Cell Alloimmunization in Transfused Patients With Sickle Cell Disease in Sub-Saharan Africa; a Systematic Review and Meta-Analysis

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