Security and reliability of CUSTOMBONE cranioplasties: A prospective multicentric study

Amelot, Aymeric; Nataloni, Angelo; François, P.; Cook, Ann-Rose; Lejeune, Jean‐Paul; Baroncini, Marc; Henaux, Pierre-Louis; Toussaint, P.; Peltier, Johann; Buffenoir, K.; Hamel, Olivier; Hieu, P. Dam; Chibbaro, Salvatore; Kehrli, P.; Lahlou, M.A.; Meneï, Philippe; Lonjon, M.; Mottolèse, C.; Peruzzi, P; Mahla, K.; Scarvada, D.; Guérinel, C. Le; Caillaud, P.; Nuti, C.; Pommier, Benjamin; Faillot, Thierry; Iakovlev, G.; Goutagny, Stéphane; Lonjon, Nicolas; Cornu, P; Bousquet, Philippe; Sabatier, Pascal; Debono, Bertrand; Lescure, J; Vicaut, Éric; Froelich, Sébastien

doi:10.1016/j.neuchi.2021.02.007

Cited by 4 publications

(6 citation statements)

References 46 publications

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“…In the second multicentric French study (Group B2) by Amelot et al, 13 we extracted data concerning 73 traumatic cranioplasties out of the total of 110 patients. There were 5 cases (6.8%) of infection in the post-traumatic group.…”

Section: Resultsmentioning

confidence: 99%

“…Groups B1 and B2 included 90 patients in total, 7 (7.8%) of which experienced a cranioplasty infection, and 5 (5.5%) required reintervention for explantation. Data concerning EI and explantation rates in post-traumatic cranioplasty from our case series, from groups B1 and B2 12,13 (no antibiotic immersion) and from group C by Iaccarino et al 14 (nonstandardized antibiotic procedure) are summarized in Supplementary Digital Content, Table 2, http://links.lww.com/SCS/D558.…”

Section: Resultsmentioning

confidence: 99%

“…Also, we compared our results with those of 2 previously published case series in which the same procedure was performed but without implants elution in antibiotics. 12,13 ; and Ospedale Umberto Parini (Via Ginevra, 3, 11100 Aosta AO). The patients were operated by senior author BZ and senior author AB, who were consultant for complex cranioplasties in each of the above hospitals.…”

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confidence: 99%

“…Also, we compared our results with those of 2 previously published case series in which the same procedure was performed but without implants elution in antibiotics. 12,13…”

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confidence: 99%

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The Antibiotic Immersion of Custom-Made Porous Hydroxyapatite Cranioplasty: A Multicentric Cohort Study

Amendola

Vaienti

Carbonaro

et al. 2022

Journal of Craniofacial Surgery

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Cranioplasty is a common neurosurgical procedure performed to reconstruct cranial defects. The most common cranioplasty materials used today can be divided into 2 types: autologous bone and bone substitutes, such as polyetheretherketone, titanium mesh, poly-methyl methacrylate, and Hydroxyapatite (HA). Infection represents one of the most feared complications, ranging from 2.3% to 20%. Early implant infections occur within 30 days from the operation and are mostly due to pathogens from the skin and the paranasal cavity. The authors aim to demonstrate the efficacy of our preoperative antibiotic immersion protocol of custom-made HA prosthesis, to prevent early implant infections. The authors compare this population to cranioplasties without preoperative antibiotic elution and those with anonstandardized antibiotic elution. The authors retrospectively analyzed data from patients referred to 6 different hospitals in northern Italy, in the period 2000 to 2020. Inclusion criteria were patients requiring reconstruction of thecal bone with HA prosthesis after post-traumatic decompressive surgery; age more than 18 years; detailed patient history and clinical data; and follow-up of minimum 6 months. A total of 77 cranioplasties were included in the study, along with 120 retrospective cases in comparison. Infections occurred in 2.6% of cranioplasties with antibiotic immersion compared to 7.8% of cranioplasties without. Even if nonsignificant, these results support our hypothesis that pretreatment of HA implants with antibiotic appears to prevent cranioplasty infections and could be a viable option to improve cranioplasty outcomes in the future.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

mentioning

confidence: 99%

“…Also, we compared our results with those of 2 previously published case series in which the same procedure was performed but without implants elution in antibiotics. 12,13…”

mentioning

confidence: 99%

See 2 more Smart Citations

The Antibiotic Immersion of Custom-Made Porous Hydroxyapatite Cranioplasty: A Multicentric Cohort Study

Amendola

Vaienti

Carbonaro

et al. 2022

Journal of Craniofacial Surgery

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“…Calcium phosphate ceramics are used for clinical applications since the 1980's. More recently, ceramic scaffolds of personalized architectures produced by additive manufacturing have been available for bone repair, e.g., Custombone TM (Amelot et al, 2021).…”

Section: Applications In the Clinical Practicementioning

confidence: 99%

Calcium phosphate bioceramics: From cell behavior to chemical-physical properties

Magnaudeix

2022

Front. Biomater. Sci.

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Calcium phosphate ceramics, including hydroxyapatite (HA), have been used as bone substitutes for more than 40 years. Their chemical composition, close to that of the bone mineral, confers them good biological and physical properties. However, they are not sufficient to meet all the needs in bone regenerative medicine, such as in the context of critical bone lesions. Therefore, it is essential to improve their biological performances in order to extend their application domains. In this aim, three approaches are mainly followed on the assumption that the biological response can be tuned by modifications of the chemical physical properties of the ceramic: 1) Incorporation of specific chemical species into the calcium phosphate crystalline lattice of chemical elements to stimulate bone repair. 2) Modulation of the bioceramic architecture to optimize the cellular responses at the interface. 3) Functionalization of the bioceramic surface with bioactive molecules. These approaches are supposed to act on separate parameters but, as they are implemented during different steps of the ceramic processing route, they cannot be considered as exclusive. They will ineluctably induces changes of several other physical chemical properties of the final ceramic that may also affect the biological response. Using examples of recent works from our laboratory, the present paper aims to describe how biology can be affected by the bioceramics modifications according to each one of these approaches. It shows that linking biological and chemical physical data in a rational way makes it possible to identify pertinent parameters and related processing levers to target a desired biological response and then more precisely tune the biological performance of ceramic biomaterials. This highlights the importance of integrating the biological evaluation into the heart of the processes used to manufacture optimized biomaterials.

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Cranioplasty With Hydroxyapatite Implants: A Multidisciplinary Approach of Neurosurgeon and Plastic Surgeons to Improve Surgical Technique and Clinical Outcome

Carbonaro,

Ghiringhelli,

Amendola

et al. 2024

Journal of Craniofacial Surgery

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Cranioplasty using Hydroxyapatite prosthesis is a conceptually simple procedure, but it may harbor several challenges for the surgeons. Several papers in the literature deal with cranioplasty using porous hydroxyapatite. The results are not homogeneous both because of the variability of the patients treated but also because Hydroxyapatite requires a more careful surgical technique to achieve maximum performance. The aim of the present study is to offer an insight of a single institution, multidisciplinary experience with custom-made Hydroxyapatite cranioplasty with surgical tips and tricks based on personal opinion and literature evidence. We will provide an overview of all the fundamental steps we believe to be useful to optimize surgical outcomes, including preoperative planning of cranioplasty; as cranioplasty flap/soft tissue coverage planning, infectious prophylaxis, patient positioning, incisional patterns, tissue dissection, primary bone demolition, and preparation of the craniectomy margins before implant positioning. The authors will also discuss methods for dural suspension, implant fixation and anchorage, margins polishing, drainage, suturing, and dressing. Cranioplasty using hydroxyapatite prosthesis is a valuable alternative for skull reconstruction with heterologous implants, and in our opinion a multidisciplinary approach integrating plastic surgeons and neurosurgeons' specific skills can facilitate surgical planning, reducing complications and allowing to achieve better functional and aesthetic results.

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Security and reliability of CUSTOMBONE cranioplasties: A prospective multicentric study

Cited by 4 publications

References 46 publications

The Antibiotic Immersion of Custom-Made Porous Hydroxyapatite Cranioplasty: A Multicentric Cohort Study

The Antibiotic Immersion of Custom-Made Porous Hydroxyapatite Cranioplasty: A Multicentric Cohort Study

Calcium phosphate bioceramics: From cell behavior to chemical-physical properties

Cranioplasty With Hydroxyapatite Implants: A Multidisciplinary Approach of Neurosurgeon and Plastic Surgeons to Improve Surgical Technique and Clinical Outcome

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