Sedación en los recién nacidos a término o casi a término con encefalopatía hipóxico-isquémica que requieren hipotermia terapéutica

Arca, Gemma; García-Alix, A.; Arnáez, Juan; Blanco, D.

doi:10.1016/j.anpedi.2014.04.030

Cited by 4 publications

(3 citation statements)

References 10 publications

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“…Secondary energy failure after 6–12 h offers a time window for disease development. Multicenter studies [ 16 – 18 ] also indicated that hypothermia treatment can significantly improve the prognosis of newborns with moderately severe HIE, as well as the time window of treatment < 6 h after birth. Nevertheless, some authors proposed that delaying treatment to within 10 h after hypoxia ischemia results in similar effectiveness [ 19 ], but studies reporting a treatment delay of 10 or even 12 h are scarce.…”

Section: Discussionmentioning

confidence: 99%

Benefits of starting hypothermia treatment within 6 h vs. 6–12 h in newborns with moderate neonatal hypoxic-ischemic encephalopathy

et al. 2018

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BackgroundIt has been suggested that mild hypothermia treatment of hypoxia-ischemic encephalopathy (HIE) should start within 6 h after HIE, but many children are admitted to the hospital > 6 h, particularly in developing areas. We aimed to determine whether hypothermia treatment could remain effective within 12 h after birth.MethodsAccording to their admission, 152 newborns were enrolled in the < 6 h and 6–12 h after HIE groups. All newborns received conventional treatment combined with mild head hypothermia therapy, according to our routine clinical practice. Some newborns only received conventional treatment (lacking informed consent). All newborns received amplitude-integrated electroencephalography (aEEG) monitoring for 4 h and neuron-specific enolase (NSE) measurement before and after 3 days of therapy.ResultsCompared to the conventional treatment, hypothermia significantly improved the aEEG scores and NSE values in all newborns of the < 6-h group. In the 6–12-h group, the aEEG scores (F = 5.67, P < 0.05) and NSE values (F = 4.98, P < 0.05) were only improved in newborns with moderate HIE. Hypothermia treatment seems to have no effect in newborns with severe HIE after 6 h (P > 0.05). Hypothermia improved the rates of neonatal death and 18-month disability (all P < 0.01).ConclusionsIn newborns with moderate HIE, starting hypothermia therapy < 6 h and 6–12 h after HIE showed curative effects. In those with severe HIE, only starting hypothermia therapy within 6 h showed curative effects.

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Section: Discussionmentioning

confidence: 99%

Benefits of starting hypothermia treatment within 6 h vs. 6–12 h in newborns with moderate neonatal hypoxic-ischemic encephalopathy

et al. 2018

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“…(61)(62) Un ensayo clínico informó acerca de mayor eficacia terapéutica de la HT frente a los resultados observados en estudios previos y esto fue atribuido a que todos los neonatos incluidos en el estudio fueron sedados. (58) El consenso SIBEN recomienda que se incluya un protocolo cuidadoso de sedo-analgesia (Tabla 3) para todos los RN con EHI que requieren ventilación asistida y para los que reciben HT. Si fuera necesario usar sedantes en RN con respiración espontánea se debe cuidar que las dosis sean bajas para no inducir apnea.…”

Section: Sedación En El Neonato Con Ehiunclassified

“…Es aconsejable un tratamiento dinámico guiado por la presencia de signos de estrés térmico como frecuencia cardíaca >120 lpm (en ausencia de drogas adrenérgicas), hipertonía flexora progresiva o discreta acidosis metabólica persistente. (58) COMORBILIDAD CON LA EHI Diversas condiciones de comorbilidad, como las variaciones de la temperatura, la glucemia y los niveles de CO 2 , se han relacionado con la modulación del daño cerebral.…”

Section: Sedación En El Neonato Con Ehiunclassified

Recomendaciones terapéuticas del VII Consenso Clínico de SIBEN para la encefalopatía hipóxico-isquémica neonatal

et al. 2016

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Starting with this issue of NeoReviews, the editorial board has decided to publish a few articles in Spanish every year and make them available online for free. To accomplish this, NeoReviews came to an agreement with SIBEN, the Ibero-American Society of Neonatology, to publish Clinical Consensus statements that the Society works very hard to produce. This collaborative process involves more than 40 neonatologists and neonatal nurses from 12 to 14 countries of the Ibero-American region, who work in various subgroups for approximately 8 to 10 months. Then the whole group meets in person for several hours to finalize the Consensus. Subsequently, 5 leaders write the final document, which is reviewed and approved by all participant members. SIBEN is a not-for-profit public charitable organization (501[c][3]) and is committed to advancing positive change for improving the delivery of neonatal care and neonatal health in Latin America. SIBEN was originally founded in 2003 by a small group of clinicians concerned with the significant discrepancy that exists in neonatal education, health care delivery, and neonatal outcomes in the Latin American region. There are members from every country in the region, totaling over 2,000 physicians and registered nurses. Five neonatologists from different countries constitute the Board of Directors. The Directive Council was recently completed and is formed by professionals from all countries and encompasses all areas of neonatal care (ie, Nursing, Interdiscipline, Family and Community; Research; Follow-up; and all others). During the last 4 to 5 years, "hands-on" educational activities in many areas have been performed. A detailed document and list are available for review at www.siben.net. A painful and regrettable significant discrepancy and inequality exists in neonatal delivery of care and outcomes in the Latin American region. The gap between what is known and clinical practice is huge in some areas. Educational programs of SIBEN are designed to improve neonatal health, safety, and outcomes and promote efficient and cost-effective neonatal health care delivery in vast areas

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Holistic approach of the care of the infant with hypoxic-ischaemic encephalopathy in Spain

Arnáez

Herranz-Rubia

García‐Alix

et al. 2020

Anales de Pediatría (English Edition)

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Sedación en los recién nacidos a término o casi a término con encefalopatía hipóxico-isquémica que requieren hipotermia terapéutica

Cited by 4 publications

References 10 publications

Benefits of starting hypothermia treatment within 6 h vs. 6–12 h in newborns with moderate neonatal hypoxic-ischemic encephalopathy

Benefits of starting hypothermia treatment within 6 h vs. 6–12 h in newborns with moderate neonatal hypoxic-ischemic encephalopathy

Recomendaciones terapéuticas del VII Consenso Clínico de SIBEN para la encefalopatía hipóxico-isquémica neonatal

Holistic approach of the care of the infant with hypoxic-ischaemic encephalopathy in Spain

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