Sedation Interruption for Mechanically Ventilated Patients—Reply

Surviving Sepsis Campaign

“…Patients receiving neuromuscular blocking agents (NMBAs) must be individually assessed regarding discontinuation of sedative drugs because the neuromuscular blockade must first be reversed. More recently, a multicenter randomized trial compared protocolized sedation with protocolized sedation plus daily sedation interruption in 423 critically ill mechanically ventilated medical and surgical patients (311). Clinical trials have evaluated daily interruption of continuous sedative infusions.…”

The Use of Analgesia and Sedation in Mechanically Ventilated Patients With COVID-19 Acute Respiratory Distress Syndrome

“…The current pandemic has proven to be a unique challenge to continue established sedation protocols and practices aimed to reduce analgesia and sedative medications. 6 The impact of large doses of sedation in patients with COVID-19 remains to be seen. A previous study has described an increased incidence of delirium with high levels of sedation, as well as long-term cognitive impairment.…”

Use of Sedation and Neuromuscular Blockers in Critically Ill Adults Receiving High-Frequency Oscillatory Ventilation

“…We converted doses of opioids to fentanyl (morphine 10 mg = fentanyl 0.1 mg = hydromorphone 2 mg), benzodiazepines to midazolam (midazolam 1 mg = lorazepam 0.5 mg), and NMBs to cisatracurium (cisatracurium 1 mg = rocuronium 6 mg = pancuronium 0.6 mg = vecuronium 0.8 mg). 26,27 Bivariate analyses were conducted using t-tests or Wilcoxon rank sum tests for continuous variables dependent on data distribution and χ 2 or Fisher exact tests for categorical variables. We summed multiple episodes of HFOV to calculate the total duration of HFOV, if HFOV was interrupted within less than 48 hours.…”