Sedative Effect of Walnut Leaf Extract and Juglone, an Isolated Constituent

Gîrzu, M.; Privat, Alain; Fialip, J.; Carnat, A.; Lamaison, Jean‐Louis

doi:10.1076/phbi.36.4.280.4580

Cited by 53 publications

(35 citation statements)

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“…As dried leaves were used, juglone was not detected in any extract, which is in accordance with Wichtl and Anton (1999). Gîrzu et al (1998) have reported the isolation of juglone from a chloroformic extract of fresh walnut leaves. In the present work it was possible to detect this compound only in the chloroformic extract from a fresh sample (data not shown).…”

Section: Resultsmentioning

confidence: 99%

“…Walnut (Juglans regia L.) leaf has been widely used in folk medicine for treatment of venous insufficiency and haemorrhoidal symptomatology, and for its antidiarrheic, antihelmintic, depurative and astringent properties (Bruneton, 1993;Van Hellemont, 1986;Wichtl & Anton, 1999). Keratolytic, antifungal, hypoglycaemic, hypotensive, anti-scrofulous and sedative activities have also been described (Gîrzu et al, 1998;Valnet, 1992).…”

Section: Introductionmentioning

confidence: 99%

“…Juglone (5-hydroxy-1,4-naphthoquinone) is the characteristic compound of Juglans spp., which is reported to occur in fresh walnut leaves (Bruneton, 1993;Gîrzu et al, 1998;Wichtl & Anton, 1999). Nevertheless, because of polymerization phenomena, juglone is reported to occur in the drug (dry leaves) only in vestigial amounts (Wichtl & Anton, 1999), which means that the compound is not suitable for use in the quality control of the dry plant.…”

Section: Introductionmentioning

confidence: 99%

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Phenolic profile in the quality control of walnut (Juglans regia L.) leaves

et al. 2004

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Qualitative and quantitative determinations of phenolic compounds were carried out on walnut leaves samples from six different cultivars, with the same agricultural, geographical and climatic conditions. The evolution of major phenolic compounds amounts was monitored from May to September. Two extractive procedures were assayed and best results were obtained using acidified water and a solid phase extraction column purification step. Qualitative analysis was performed by HPLC-DAD/MS and, in all samples, seven phenolic compounds were identified (3-caffeoylquinic, 3-p-coumaroylquinic and 4-p-coumaroylquinic acids, quercetin 3-galactoside, quercetin 3-arabinoside, quercetin 3-xyloside, quercetin 3-rhamnoside) and two other partially identified phenolics (quercetin 3-pentoside and kaempferol 3-pentoside derivatives) were also detected. Quantification of phenolic compounds was performed by HPLC-DAD, which revealed that quercetin 3-galactoside was always the major compound while 4-p-coumaroylquinic acid was the minor one. The highest content of phenolics was found in May and July.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Phenolic profile in the quality control of walnut (Juglans regia L.) leaves

et al. 2004

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“…Juglone (5-hydroxy-1,4-naphthoquinone) is known as being the characteristic compound of Juglans spp. and is reported to occur in fresh walnut leaves (Bruneton, 1993;Gîrzu et al, 1998;Solar et al, 2006;Wichtl & Anton, 1999). Nevertheless, because of polymerization phenomena, juglone only occurs in dry leaves at vestigial amounts (Wichtl & Anton, 1999).…”

Section: Discussionmentioning

confidence: 99%

“…Walnut leaves are considered a source of healthcare compounds, and have been widely used in traditional medicine for he treatment of skin inflammation, venous insufficiency, hyperhidrosis haemorrhoidal symptomatology and ulcers, and for its antidiarrheic, antihelmintic, depurative, antiseptic, antibacterial, astringent, antioxidants and chemopreventive properties (Alkhawajah, 1997;Bruneton, 1993Bruneton, , 1999Carvalho et al, 2010;Van Hellemont, 1986;Wichtl & Anton, 1999). Keratolytic, antifungal, hypoglycaemic, hypotensive, anti-scrofulous and sedative activities have also been described (Gîrzu et al, 1998;Valnet, 1992).…”

Section: Introductionmentioning

confidence: 99%

Hepatoprotective effects of Juglans regia extract against CCl₄-induced oxidative damage in rats

Eidi

Moghadam

Mortazavi

et al. 2013

Pharmaceutical Biology

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Context: Different parts of the walnut [Juglans regia L. (Juglandaceae)] have been used in folk medicine for protection against liver injury, although its actual efficacy remains uncertain. Objective: The present study investigated the protective effect of walnut leaf extract against carbon tetrachloride (CCl 4 )-induced liver damage in rats. Materials and methods: The rats were randomly divided into seven groups: control, CCl 4 (i.p., 0.5 mL/kg b.w., 50% CCl 4 in olive oil), walnut extract (at dose level of 0.2 g/kg b.w.) alone, walnut extract (at dose levels of 0.05, 0.1, 0.2 and 0.4 g/kg b.w.) with CCl 4 , and treatment was carried out accordingly. On the 28th day, rats were sacrificed and blood was withdrawn by cardiac puncture. Liver damage was assessed by serum biochemical parameters (alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase and albumin), antioxidant enzymes (superoxide dismutase and catalase) and histopathological observation. Results: Administration of walnut leaf extract (ranging from 0.2 to 0.4 g/kg b.w.) significantly lowered serum alanine aminotransferase, aspartate aminotransferase and alkaline phosphatase levels in CCl 4 -treated rats. Walnut leaf extract increased antioxidant enzymes, including superoxide dismutase and catalase. Histopathological examination of livers showed that walnut leaves extract reduced fatty degeneration, cytoplasmic vacuolization and necrosis in CCl 4 -treated rats. Discussion and conclusion: These results suggest that walnut extract has a protective effect over CCl 4 -induced oxidative damage in rat liver. These results demonstrate that walnut extract acts as a good hepatoprotective and antioxidant agent in attenuating hepatocellular damage.

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Phytochemical Investigation by Microwave‐Assisted Extraction of Essential Oil of the Leaves of Walnut Cultivated in Algeria

Boukhari

Tigrine-Kordjani

Meklati

2013

Helvetica Chimica Acta

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Walnut (Juglans regia L.) leaves are used traditionally as an herbal tea indicated for non-insulindependent diabetics. In recent years, the type-II diabetes is occurring worldwide with increasing frequency. Thus, there is an urgent need to explore the new beneficial biomolecules on the human health. Our objective was to investigate, for the first time, the volatiles profile of Juglans regia L. leaves from Algiers region. The extraction of essential oil of fresh plant material was performed by microwaveassisted hydrodistillation (MAHD), for the first time, a relatively recent method, then by the conventional hydrodistillation technique (HD) for comparison. The collected extracts were analyzed by GC-FID and GC/MS using two capillary columns with different polarity. Extraction time of 1 h by MAHD provided higher yields (0.050 AE 0.001% (w/w)) than by HD (0.030 AE 0.006% (w/w)) after 3 h. A total of 38 compounds were identified using both techniques. Essential oils had similar qualitative but different quantitative composition in terms of chemical compounds. The MAHD method improved yield while reducing the extraction time. The sesquiterpenes were the dominant family in both MAHD and HD essential oils with b-caryophyllene being the major constituent. Monoterpenes, including hydrocarbon and oxygenated, prevail in HD volatile fraction with b-pinene and eucalyptol, respectively, as major components.

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Sedative Effect of Walnut Leaf Extract and Juglone, an Isolated Constituent

Cited by 53 publications

References 6 publications

Phenolic profile in the quality control of walnut (Juglans regia L.) leaves

Phenolic profile in the quality control of walnut (Juglans regia L.) leaves

Hepatoprotective effects of Juglans regia extract against CCl₄-induced oxidative damage in rats

Phytochemical Investigation by Microwave‐Assisted Extraction of Essential Oil of the Leaves of Walnut Cultivated in Algeria

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Sedative Effect of Walnut Leaf Extract and Juglone, an Isolated Constituent

Cited by 53 publications

References 6 publications

Phenolic profile in the quality control of walnut (Juglans regia L.) leaves

Phenolic profile in the quality control of walnut (Juglans regia L.) leaves

Hepatoprotective effects of Juglans regia extract against CCl4-induced oxidative damage in rats

Phytochemical Investigation by Microwave‐Assisted Extraction of Essential Oil of the Leaves of Walnut Cultivated in Algeria

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Hepatoprotective effects of Juglans regia extract against CCl₄-induced oxidative damage in rats