Sedentary Behaviors Increase Risk Of Cardiovascular Disease Mortality In Men

Sedentary behaviour and risk of mortality from all-causes and cardiometabolic diseases in adults: evidence from the HUNT3 population cohort

“…Previous studies examining sedentary behaviour and CVD-related mortality have reported that higher levels of total sitting time,5 10 TV-viewing5 6 and occupational sitting24 25 27 are associated with higher risk of CVD-related mortality, although others have also found no associations with TV-viewing11 or occupational sitting 28 29. In this study, we found that the risk of death from CMD in HUNT3 participants associated with total sitting time per day was 115% higher in people sitting ≥10 h/day relative to those sitting <4 h/day, but no association with the levels of TV-viewing and occupational sitting.…”

“…Evidence from prospective studies suggests that all-cause and/or CVD-related mortality is positively associated with specific sedentary behaviour contexts and domains, including TV-viewing,5–7 leisure screen-based activity,8 leisure-time sitting,9 sitting in main activities (during work, school and housework),10 riding in a car11 and occupations involving ‘mostly sitting’ 12. Three prospective studies indicate that higher amounts of total time spent sitting is associated with greater risk of all-cause5 13 14 and CVD-related5 mortality and that associations between total sitting time and mortality are independent of the participants’ physical activity5 13 14 When assessed objectively with accelerometers, higher sedentary time also appears to be associated with higher risk of mortality independent of moderate-to-vigorous physical activity 15…”

Excessive sedentary time and low cardiorespiratory fitness in European adolescents: the HELENA study

“…A second important aim of our study was to examine whether the inverse association between sedentary time and CRF in adolescents girls was independent of physical activity levels since several studies have shown that sedentary time might have a negative role on CVD development independently of physical activity 13–15. To avoid possible multicollinearity by including sedentary time and physical activity variables in the same model, we divided the sample into two groups according to the current physical activity recommendations for adolescents.…”

Multicomponent intervention to reduce daily sedentary time: a randomised controlled trial

“…Strengths and limitations of this study ▪ The primary strengths of this study include (1) among the first randomised controlled trials (RCTs) to target sedentary time as a primary outcome; (2) among the first RCTs to use an objective measure of sedentary time; (3) conducted a 12-week trial which extends previous sedentary interventions that have typically been of brief durations; (4) measured cardiometabolic risk factors and (5) conducted a process evaluation to identify features of the intervention that worked particularly well. ▪ The primary limitations of this study include (1) small sample size (N=40) comprising primarily of middle-aged women working at a single institution which limits generalisability and (2) differential dropout, although follow-up analyses indicate no differences between those who dropped out and those who completed for age (p=0.48), body mass index ( p=0.63) or daily sedentary time ( p=0.32).…”