Seeding of Gastric Adenocarcinoma Cells to the Skin After Invasive Procedures

García‐González, Edith; Alvarez-Paque, Leonardo; Loyola-Zárate, Maríana; Lisker‐Melman, Mauricio

doi:10.1097/00004836-199801000-00022

Cited by 5 publications

(5 citation statements)

References 14 publications

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“…Nevertheless, such lesions arising from gastric adenocarcinoma are extremely rare, occurring after palliative percutaneously performed gastrostomy for unresected tumours [2] or after potentially curative surgery at the sites of surgical drains [3, 4], as in our patient.…”

Section: Discussionmentioning

confidence: 99%

Cutaneous Metastasis at a Surgical Drain Site after Gastric Cancer Resection

Karayiannakis¹,

Bolanaki²,

Tsalikidis³

et al. 2010

Case Rep Oncol

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Cutaneous metastasis from intra-abdominal malignant solid tumours such as gastric adenocarcinoma is very rare. Here, we report the case of a 76-year-old male patient with a T4N2M0, poorly differentiated, signet-ring cell gastric carcinoma, who underwent potentially curative resection of the tumour and developed cutaneous metastasis at the site of the surgical drain 4 months after the operation while he was on chemotherapy. The lesion involved the skin and the subcutaneous fat only. A CT scan revealed local recurrence at the resection bed but no distant metastases. The patient died 1 month later. It is concluded that the development of cutaneous metastasis after gastric carcinoma resection indicates tumour recurrence or disseminated disease and is associated with poor prognosis.

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Section: Discussionmentioning

confidence: 99%

Cutaneous Metastasis at a Surgical Drain Site after Gastric Cancer Resection

Karayiannakis¹,

Bolanaki²,

Tsalikidis³

et al. 2010

Case Rep Oncol

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“…Cutaneous metastases are the 12th most frequent site for all tumour types (7). Skin infiltration may be the first sign of carcinoma, or it may accompany other symptoms or be noted during follow-up (4).The incidence of skin metastasis is 1% to 2.7% (1).…”

Section: Discussionmentioning

confidence: 99%

“…Brownstein and Helwig (2) reported that the scalp was the site in 4% of all skin metastases. Metastases to the skin from various internal organs are uncommon (7). It has been claimed that skin metastases tend to be close to the site of the primary tumour: chest in breast and lung cancers, abdominal wall in gastrointestinal tumours and lower back in renal cell carcinomas (9).…”

Section: Discussionmentioning

confidence: 99%

“…Skin metastases from primary gastric carcinoma are very uncommon (10); the incidence varies from 0.04% in clinical series to 9% in Skin metastasis from an occult esophageal adenocarcinoma Figure 5) Immunohistochemical staining for CK7 shows positivity for both the skin metastasis (A) (original magnification ×400); and esophageal tumour cells (B) (original magnification ×100) Figure 6) Immunohistochemical staining for p53 is positive in the skin (A) and in the esophageal tumour cells (B). Original magnification ×200 autopsies (7). Skin metastases are classified macroscopically as nodular, inflammatory or sclerodermoid (1).…”

Section: Discussionmentioning

confidence: 99%

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Skin Metastasis from an Occult Esophageal Adenocarcinoma

Fereidooni

Kovács²,

Azizi³

et al. 2005

Canadian Journal of Gastroenterology

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Metastases to the skin from carcinoma arising in other organs are uncommon, yet they may be the first presentation of neoplastic disease. They usually originate from primary tumours in the breast, lung or colon. Skin metastases from esophageal adenocarcinoma are extremely rare. A unique case of an otherwise healthy patient who presented with a small, painless, mobile, clinically localized facial skin nodule is reported. A biopsy revealed metastatic adenocarcinoma, and subsequent investigations detected the primary tumour in the esophagus, despite no symptoms.

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“…Isolated superficial metastases have been also described following invasive procedures ( i.e. laparoscopic surgery) 9,10. Peristomal metastases represent an even rarer, but challenging finding, due to possible bowel obstruction and trouble in ostomy management.…”

Section: Introductionmentioning

confidence: 99%

Minimally invasive treatment of peristomal metastases from gastric cancer at an ileostomy site by electrochemotherapy

Campana¹,

Scarpa²,

Sommariva³

et al. 2013

Radiology and Oncology

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BackgroundPeristomal metastases are rare, but potentially associated with relevant morbidity. Surgical resection, followed by stoma relocation, represent the gold standard in most patients. We describe electrochemotherapy (ECT), a minimally invasive method for locally-enhancing drug delivery by means of electric pulses, as an alternative approach.Patient and methodsA 49-year-old man with advanced gastric cancer developed skin metastases around an ileostomy site. The ulcerated and oozing tumor growth impaired patient’s quality of life due to continuous trouble in fitting the ostomy appliance, its poor adherence and consequent stools spillage. ECT consisted of a 20-minute course under mild general sedation. A bleomycin bolus of 15 000 IU/m2 was followed by the percutaneous application of multiple, 1.5 ms -long electric pulses by means of a needle electrode.ResultsPost ECT course was uneventful and the patient was discharged on the same day. After one week, tumor nodules were flattened and partial tumor regression was appreciable at one-month follow-up. More importantly, peristomal skin conditions significantly improved, thus allowing for an effective application of the ostomy appliance during the following moths, until patient’s death.ConclusionsThis report suggests the feasibility of ECT as a minimally invasive approach for peristomal tumors. In selected cases, ECT, by achieving a rapid tumor control, may ensure effective ostomy management and preserve patients’ quality of life.

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Seeding of Gastric Adenocarcinoma Cells to the Skin After Invasive Procedures

Cited by 5 publications

References 14 publications

Cutaneous Metastasis at a Surgical Drain Site after Gastric Cancer Resection

Cutaneous Metastasis at a Surgical Drain Site after Gastric Cancer Resection

Skin Metastasis from an Occult Esophageal Adenocarcinoma

Minimally invasive treatment of peristomal metastases from gastric cancer at an ileostomy site by electrochemotherapy

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