Seedless Synthesis of Monodispersed Gold Nanorods with Remarkably High Yield: Synergistic Effect of Template Modification and Growth Kinetics Regulation

Liu, Kang; Bu, Yanru; Zheng, Yuanhui; Jiang, Xuchuan; Yu, Aibing; Wang, Huanting

doi:10.1002/chem.201605617

Cited by 22 publications

(5 citation statements)

References 40 publications

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“…29,30 Later, El-Sayed and co-workers 31 showed that decreasing the solution pH with HCl could produce nanorods smaller than those obtained with conventional seeded syntheses. Conversely, another study 32 catechol (1,2-dihydroxybenzene), resorcinol (1,3-dihydroxybenzene), 33 dopamine (3,4-dihydroxyphenethylamine), 34 1,2,4-trihydroxybenzene, 35 pyrogallol, 36 and 5-bromosalicylic acid 37 have been used to further improve the monodispersity and control the nanorod dimensions in the seed-mediated and seedless syntheses. Recently, dopamine was used both as a reducing agent and as a stabilizer whereby the CTAB concentration could be reduced to 22 mM from 100 mM with tunable LSPR wavelengths between 700 and 1050 nm in high yield.…”

Section: ■ Introductionmentioning

confidence: 99%

Accelerating Gold Nanorod Synthesis with Nanomolar Concentrations of Poly(vinylpyrrolidone)

et al. 2017

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A novel modification for the seedless synthesis of gold nanorods (AuNRs) has been developed. Nanomolar concentrations of 10 kDa poly(vinylpyrrolidone) (PVP) can be introduced to a growth solution containing 25, 50, or 100 mM cetyltrimethylammonium bromide (CTAB) to significantly reduce the dimensions of AuNRs. We found that PVP accelerates the growth rate of AuNRs by more than two times that of nanorods grown in 50 and 100 mM CTAB solutions. Additionally, there is a time-dependent effect of adding PVP to the nanorod growth solution that can be utilized to tune their aspect ratio. Because the concentration of PVP is far below the concentration of HAuCl in the reaction mixture, PVP primarily functions not as a reducing agent, but as a capping or templating ligand to stabilize the growing nanorods. Our reproducible protocol enables the synthesis of AuNRs in high yield with tunable sizes: 45 × 6.7, 28 × 5.5, and 12 × 4.5 nm for 100, 50, and 25 mM CTAB, respectively. We estimated the number of PVP chains per nanorod in growth solutions to be around 30, which suggests that the effect on the aspect ratio is caused by a direct interaction between the AuNR surface and the PVP.

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Section: ■ Introductionmentioning

confidence: 99%

Accelerating Gold Nanorod Synthesis with Nanomolar Concentrations of Poly(vinylpyrrolidone)

et al. 2017

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“…Improve morphology Adjusting the concentrations of CTAB and sodium oleate Roach et al (2018) Promote the anisotropic growth Introducing a weaker reducing agent (hydroquinone), with template modification Liu et al (2017a) Introducing a weaker reducing agent (resveratrol) Wang et al (2016b) Improve the yield Increasing the concentration of the gold precursor solution Yan et al (2018) Yang et al (2016b) Human induced pluripotent stem cells loaded with GNRs @SiO2@CXCR4 nanoparticles which were pre-treated with mitomycinC (MMC)…”

Section: Seedless Methodsmentioning

confidence: 99%

Improvement of Gold Nanorods in Photothermal Therapy: Recent Progress and Perspective

et al. 2021

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Cancer is a life-threatening disease, and there is a significant need for novel technologies to treat cancer with an effective outcome and low toxicity. Photothermal therapy (PTT) is a noninvasive therapeutic tool that transports nanomaterials into tumors, absorbing light energy and converting it into heat, thus killing tumor cells. Gold nanorods (GNRs) have attracted widespread attention in recent years due to their unique optical and electronic properties and potential applications in biological imaging, molecular detection, and drug delivery, especially in the PTT of cancer and other diseases. This review summarizes the recent progress in the synthesis methods and surface functionalization of GNRs for PTT. The current major synthetic methods of GNRs and recently improved measures to reduce toxicity, increase yield, and control particle size and shape are first introduced, followed by various surface functionalization approaches to construct a controlled drug release system, increase cell uptake, and improve pharmacokinetics and tumor-targeting effect, thus enhancing the photothermal effect of killing the tumor. Finally, a brief outlook for the future development of GNRs modification and functionalization in PTT is proposed.

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“…The use of HQ has been exploited for the seedless modified protocol proposed by Wang in 2017 [ 38 ]. The authors introduced two main modifications: the introduction of 5-bromosalicylic acid (5-BA) as template regulator at the beginning of the micellar formation and the addition of HQ as weak reducing agent during the growth phase ( Figure 5 ).…”

Section: Synthesismentioning

confidence: 99%

“… Scheme of seedless synthesis technique based on the use of 5-bromosalicylic acid and hydroquinone. Reproduced from [ 38 ] with permission from the John Wiley and Sons. …”

Section: Figurementioning

confidence: 99%

Anisotropic Gold Nanoparticles in Biomedical Applications

Kohout

Santi

Polito

2018

IJMS

110

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Gold nanoparticles (AuNPs) play a crucial role in the development of nanomedicine, principally due to their unique photophysical properties and high biocompatibility. The possibility to tune and customize the localized surface plasmon resonance (LSPR) toward near-infrared region by modulating the AuNP shape is one of the reasons for the huge widespread use of AuNPs. The controlled synthesis of no-symmetrical nanoparticles, named anisotropic, is an exciting goal achieved by the scientific community which explains the exponential increase of the number of publications related to the synthesis and use of such type of AuNPs. Even with such steps forward and the AuNP translation in clinic being done, some key issues are still remain and they are related to a reliable and scalable production, a full characterization, and to the development of nanotoxicology studies on the long run. In this review we highlight the very recent advances on the synthesis of the main classes of anisotropic AuNPs (nanorods, nanourchins and nanocages) and their use in the biomedical fields, in terms of diagnosis and therapeutics.

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Seedless Synthesis of Monodispersed Gold Nanorods with Remarkably High Yield: Synergistic Effect of Template Modification and Growth Kinetics Regulation

Cited by 22 publications

References 40 publications

Accelerating Gold Nanorod Synthesis with Nanomolar Concentrations of Poly(vinylpyrrolidone)

Accelerating Gold Nanorod Synthesis with Nanomolar Concentrations of Poly(vinylpyrrolidone)

Improvement of Gold Nanorods in Photothermal Therapy: Recent Progress and Perspective

Anisotropic Gold Nanoparticles in Biomedical Applications

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