“…In this work, four statistical methods were used for texture analysis of corneal images. These are: six first-order image histogram (FOS) measures (Mean value, Standard deviation, Skewness, Kurtosis, Entropy and Energy) [16,17]; nine grey-level cooccurrence matrix (GLCM) measures (Contrast, Correlation, Energy and Homogeneity, Entropy, mean of row, Standard deviations of row, Absolute value and Inverse difference moment) [16,17] all calculated using distances d = 7, 9, 11, 13, 15, 17 and 21 and angles θ = 0º, 45º, 90º and 135º; the value of a distance d is dependent on texture type, as it requires a small values for fine texture and a large values for coarse textures [18]; fourteen Law's masks and texture energy measures (TEM) calculated from E5L5, S5L5, W5L5, R5L5, E5S5, E5E5, E5R5, E5W5, S5R5, S5W5, S5S5, W5R5, W5W5, R5R5 [19][20][21]; sixteen grey run-length matrix (GRLM) measures with 8 quantization levels (Short runs emphasis, Long runs emphasis, Grey level non-uniformity and Run length nonuniformity, all calculated in the 4 directions θ = 0º, 45º, 90º and 135º) [22,23]. 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 5 Artificial Neural Networks (ANNs) are widely used for classification purposes in many different applications including engineering, finance, health and medicine because they have proved to have powerful capabilities [24,…”