Segregation Analysis of Canine Hip Dysplasia in Cane Corso Italiano Dogs

Korec, E

doi:10.31031/apdv.2018.02.000539

Cited by 2 publications

(1 citation statement)

References 14 publications

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“…In France, a program intending to reduce HD prevalence was introduced in 1971 under the responsibility of each breed club and supervised by the French Kennel Club (SCC: Société Centrale Canine) [7]. Currently, phenotypic screening for coxo-femoral joint conformation remains a strategy for breeders for making selection decisions [8]. Radiographic screening for HD is based on a conventional ventrodorsal hip extended radiograph in anaesthetized or deeply sedated dogs.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of canine hip dysplasia in 10 breeds in France, a retrospective study of the 1997-2017 radiographic screening period

et al. 2020

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Canine hip dysplasia (HD) is a complex developmental disease of the coxo-femoral joint and is one of the most common orthopedic conditions in dogs. Due to the genetic contribution, most of the programs fighting against HD recommend selective breeding that excludes affected dogs. Using the best-scoring dogs for breeding may reduce the prevalence of HD. In France, the phenotypic screening of coxo-femoral joint conformation remains a strategy for breeders to establish selection decisions. The HD prevalence was evaluated in 10 breeds, based on the assessment of 27,710 dogs, during the 1997-2017 screening period, which was divided into 3 homogeneous cohorts for analysis. The global HD prevalence varied widely among breeds from 5% (Siberian Husky) to 51.9% (Cane Corso). It decreased over time in 6 breeds, among which 4 (Cane Corso, Gordon Setter, Rottweiler and White Swiss Shepherd) showed a significant decrease. A statistically significant increase in HD prevalence was noted for the Siberian Husky. Although the efficacy of phenotype-based breeding programs remains controversial, our results are in accordance with several recent studies showing that longterm selection policies are valuable, as they may help decreasing the HD prevalence in some breeds. The complementary use of more recent tools such as estimated breeding values and genomics would probably help breeders achieve more substantive results.

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Section: Introductionmentioning

confidence: 99%

Prevalence of canine hip dysplasia in 10 breeds in France, a retrospective study of the 1997-2017 radiographic screening period

et al. 2020

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Four novel genes associated with longevity found in Cane corso purebred dogs

et al. 2022

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Background Longevity-related genes have been found in several animal species as well as in humans. The goal of this study was to perform genetic analysis of long-lived Cane corso dogs with the aim to find genes that are associated with longevity. Results SNPs with particular nucleotides were significantly overrepresented in long-lived dogs in four genes, TDRP, MC2R, FBXO25 and FBXL21. In FBXL21, the longevity-associated SNP localises to the exon. In the FBXL21 protein, tryptophan in long-lived dogs replaced arginine present in reference dogs. Conclusions Four SNPs associated with longevity in dogs were identified using GWAS and validated by DNA sequencing. We conclude that genes TDRP, MC2R, FBXO25 and FBXL21 are associated with longevity in Cane corso dogs.

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Segregation Analysis of Canine Hip Dysplasia in Cane Corso Italiano Dogs

Abstract: Materials and Methods Data collectionData was obtained from 1813 CHD scored dogs, using the Cane Corso Italiano Pedigree Database (www.canecorsopedigree.com). FCI official guidelines were used for scoring CHD.

Cited by 2 publications

References 14 publications

Prevalence of canine hip dysplasia in 10 breeds in France, a retrospective study of the 1997-2017 radiographic screening period

Prevalence of canine hip dysplasia in 10 breeds in France, a retrospective study of the 1997-2017 radiographic screening period

Four novel genes associated with longevity found in Cane corso purebred dogs

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