We present high-resolution Vp and Vp/Vs models of the southern Apennines (Italy) computed using local earthquakes recorded from 2006 to 2011 with a graded inversion scheme that progressively resolves the crustal structure, from the large scale of the Apennines belt to the local scale of the normal fault system. High-Vp bodies defined in the upper crust and midcrust under the external Apennines are interpreted as extensive mafic intrusions revealing anorogenic magmatism episodes that broadened on the Adriatic domain during Paleogene. Under the mountain belt, a low-Vp region, annular to the Neapolitan volcanic district, indicates the existence of a thermal/fluid anomaly in the midcrust, coinciding with a shallow Moho and diffuse degassing of deeply derived CO 2 . In the belt axial zone, low-Vp/Vs gas-pressurized rock volumes under the Apulian carbonates correlate to high heat flow, strong CO 2 -dominated gas emissions of mantle origin, and shallow carbonate reservoirs with pressurized CO 2 gas caps. We hypothesize that the pressurized fluid volumes located at the base of the active fault system influence the rupture process of large normal faulting earthquakes, like the 1980 Mw6.9 Irpinia event, and that major asperities are confined within the high-Vp Apulian carbonates. This study confirms once more that preexisting structures of the Pliocene Apulian belt controlled the rupture propagation during the Irpinia earthquake. The main shock broke a~30 km long, NE dipping seismogenic structure, whereas delayed ruptures (both the 20 s and the 40 s subevents) developed on antithetic faults, reactivating thrust faults located at the eastern edge of the Apulian belt.