Equivalent frame method (EFM) is widely used for the nonlinear static and dynamic analyses in the engineering applications for seismic assessment and design verification of masonry buildings due to its efficiency in the performance prediction and high computational ease. The available large data base on the nonlinear response of masonry elements makes EFM as a suitable choice for the analysis and an ideal option when large building stock and/or parametric sensitivity analyses are under consideration. The available constitutive laws for masonry elements, generally recommended, are investigated in the prediction of seismic displacement demand on the buildings using nonlinear time history analysis (NLTHA) against the analytical prediction using secant vibration period and overdamped spectrum with the bias in the prediction being quantified. The investigation is performed on two to five storey masonry buildings of Pakistan using six different available frame elements constitutive laws. The investigation shows that the bi-linear constitutive law, Takeda type rule, with Emori type of unloading give relatively more consistent results. The effect of different spectral reduction factors, recommended by Euro Code 8, is also investigated.