The problem of pile - soil interaction is examined in the Thesis at hand by means of both theoretical analyses and experimental investigations. Pile foundations in seismically prone areas are subjected to both direct loading, such as axial and lateral forces imposed at their heads, resulting from a phenomenon known as inertial interaction, and indirect loading along their body, such as imposed displacements due to the passage of various types of seismic waves, resulting from a phenomenon known as kinematic interaction. Along this vein, a family of analytical models of the Tajimi type are presented in the framework of linear elastodynamic theory to explore the effects of axial and lateral pile - soil interaction in homogeneous and inhomogeneous soil under static and dynamic (kinematic and inertial) loading. Apart from simplified two-dimensional models of the Baranov - Novak type, few analytical solutions are available to tackle these problems in three dimensions, the majority of which are restricted to the analysis of an elastic half space under static conditions.The proposed models are based on a continuum solution pioneered by Japanese investigators (notably Matuso & Ohara and Tajimi) in the 1960’s. In the realm of this approach the soil is modelled as a continuum, while the pile is conveniently modelled as a rod or a beam by strength-of-materials theory. Displacements and stresses are expressed through Fourier series in terms of the natural modes of the soil medium.Fundamental to the analysis presented in this study is that the influence of horizontal soil displacement on axial pile response and vertical displacement on lateral response, respectively, are negligible. However, their effect on stresses is not negligible which differentiates the proposed models from the classical Tajimi solutions in which the aforementioned displacements are set equal to zero. The above approximations are attractive, as they lead to a straightforward uncoupling of the equations of motions, even in inhomogeneous media, unlike the classical elastodynamic theory where the uncoupling is generally impossible in presence of inhomogeneity.Although approximate, the proposed models are advantageous over available analytical models and rigorous numerical schemes, as they require relative simple computations and provide excellent predictions of pile response at the frequency ranges of interest in earthquake engineering and geotechnics. In addition, they are advantageous over existing simplified analytical approaches of the Winkler type, as they are more accurate, self - standing, free of empirical constants and provide more realistic simulation of the problem. The main advantage over numerical methods (finite and boundary elements) lies in the derivation of the solution in closed form and the elucidation of complex mechanisms related to the dynamic interaction phenomenon, such as radiation damping and wave propagation in in homogeneous media.The main goal of the theoretical effort lies in the derivation of solutions in closed - form for: (i) the static stiffness and the dynamic impedances (dynamic stiffness and damping coefficients) at the pile head, (ii) translational and rotational kinematic response factors (pile head displacement or rotation over free-field response), (iii) actual, depth- dependent, Winkler moduli (spring and damping coefficients), (iv) corresponding average, depth- independent, Winkler moduli to match the pile head stiffness. In addition, simple approximate formulae for Winkler moduli to be used in engineering practice are proposed, to improve the predictions of Winkler models.Pile-to-pile interaction is investigated on the basis of the superposition method for axially loaded piles. Closed-form expressions for attenuation functions are derived to be used individually or in conjunction with more elaborate methods providing more accurate predictions for static and dynamic interaction factors to assess the vertical stiffness of pile groups. New dimensionless frequency ratios controlling pile response are introduced.Finally, new solutions are added in the context of analytical Winkler models for investigating the behaviour of piles under kinematic loading due to vertically-propagating S waves. Emphasis is given on the influence of boundary conditions of the pile. With reference to kinematic pile bending, insight into the physics of the problem is gained through a rigorous superposition scheme involving an infinitely-long pile excited kinematically, and a pile of finite length excited by a concentrated force and a moment at the tip. Contrary to the classical elastodynamic theory where pile response is governed by six dimensionless ratios, in the realm of Winkler theory three only ratios suffice to fully describe the interaction problem, from which the mechanical slenderness and the effective dimensionless frequency are introduced for the first time. The selection of an appropriate value for the Winkler modulus in the accuracy of the kinematic Winkler model is demonstrated.The theoretical results are compared to new experimental data obtained from a series of tests on piles carried out on scaled models performed on the shaking table at University of Bristol Laboratory (BLADE) within the framework of the Seismic Engineering Research Infrastructures (SERIES) program, sponsored by FP7, and contribute in the investigation of pile - soil interaction.