The load features of ground motion are mainly reflected by three factors: amplitude, frequency, and duration. The combination of these factors determines the response of rock-soil mass and the structure safety under seismic load. By finite element method, this paper analyzes the influence of the three factors of ground motion on the dynamic response of a slope. The analysis shows that the slope displacement increased with the elevation from the bottom. The anti-dip fault puts the slope in an unfavorable deformation state. Due to the large residual deformation in the fault zone, a large displacement occurred on the slope top. It was also learned that the adjustment of amplitude only leads to proportional growth in the absolute value of the acceleration of the slope. Under the same conditions, the dynamic responses in different parts of the target slope are not greatly affected by the changing amplitude, but depend more on the material and spectral features of the rock-soil mass. The research results provide a reference for the evaluation and prediction of slope seismic stability and the evolution of slope damage under earthquakes with different frequencies, amplitudes, and durations.